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One Hundred Years of Insanity: Genomic, Psychological, and Evolutionary Models of Autism in Relation to Schizophrenia

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Handbook of Schizophrenia Spectrum Disorders, Volume I

Abstract

The Swiss psychiatrist Eugen Bleuler coined the terms “schizophrenia”, for the splitting of psychic functions, and “autism”, for withdrawal from external reality in patients with schizophrenia, almost exactly a century ago. Ever since 1943 when Leo Kanner co-opted “autism” to refer to a new condition involving “disturbance of affective contact” manifested in children, the relationship between schizophrenia and Kanner’s autism has remained unclear. In this article I draw on data from studies of genomics, neurodevelopment, psychology, psychiatry and evolutionary biology to develop and evaluate alternative hypotheses for the relationship between autism and schizophrenia spectrum conditions. These data provide evidence for two hypotheses: partially-overlapping etiology of autism with schizophrenia mediated by common risk factors, and diametric causes of autism and schizophrenia mediated by genes underlying under-development versus dysregulated over-development of human social-brain phenotypes. The primary practical implications of these results are that: (1) false-positive diagnoses of premorbidity to schizophrenia-spectrum conditions as autistic spectrum conditions may be common, and may indicate a structural flaw in current diagnostic, nosological frameworks; (2) schizophrenia may be due in part to losses of function in negative regulators of social cognition and affect, rather than “deficits” in brain development; (3) the development of new pharmacological treatments for autism and schizophrenia can benefit directly from models of how autistic spectrum and schizophrenia spectrum conditions are etiologically related; and (4) future studies of autism, schizophrenia, and their relationship to one another must increasingly seek to integrate across analytic levels, from genes to neurodevelopment, neurological function, neuroanatomy, cognition, and evolutionary biology of the social brain, in the context of subtyping the substantial genetic and clinical heterogeneity found in each set of conditions.

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Abbreviations

DSM-IV:

Diagnostic and statistical manual of mental disorders

PDD-NOS:

Pervasive developmental disorder not otherwise specified

References

  1. Bleuler PE (1951) Dementia praecox or the group of schizophrenias (trans: Zinkin J). Allen and Unwin, London

    Google Scholar 

  2. Kanner L (1943) Autistic disturbances of affective contact. Nerv Child 2:217–250

    Google Scholar 

  3. McNally K (2009) Eugene Bleuler’s four As. Hist Psychol 12:43–59

    PubMed  Google Scholar 

  4. Remschmidy HE, Schulz E, Martin M et al (1994) Childhood-onset schizophrenia: history of the concept and recent studies. Schizophr Bull 20:727–745

    Google Scholar 

  5. Starling J, Dossetor D (2009) Pervasive developmental disorders and psychosis. Curr Psychiatry Rep 11:190–196

    PubMed  Google Scholar 

  6. Kolvin I (1971) Studies in the childhood psychoses. I. Diagnostic criteria and classification. Br J Psychiatry 118:381–384

    CAS  PubMed  Google Scholar 

  7. Rutter M (1968) Concepts of autism: a review of research. J Child Psychol Psychiatry 9:1–25

    CAS  PubMed  Google Scholar 

  8. Rutter M (1972) Childhood schizophrenia reconsidered. J Autism Child Schizophr 2:315–337

    CAS  PubMed  Google Scholar 

  9. Rutter M (1978) Diagnosis and definition of childhood autism. J Autism Child Schizophr 8:139–161

    CAS  PubMed  Google Scholar 

  10. Wing L (1993) The definition and prevalence of autism: a review. Eur Child Adolesc Psychiatry 2:61–74

    Google Scholar 

  11. Lauritsen MB, Pedersen CB, Mortensen PB (2004) The incidence and prevalence of pervasive developmental disorders: a Danish population-based study. Psychol Med 34:1339–1346

    CAS  PubMed  Google Scholar 

  12. Happé F, Ronald A (2008) The ‘Fractionable autism triad’: a review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychol Rev 18:287–304

    PubMed  Google Scholar 

  13. Walker DR, Thompson A, Zwaigenbaum L et al (2004) Specifying PDD-NOS: a comparison of PDD-NOS, Asperger syndrome, and autism. J Am Acad Child Adolesc Psychiatry 43:172–180

    PubMed  Google Scholar 

  14. Brüne M (2005) “Theory of mind” in schizophrenia: a review of the literature. Schizophr Bull 31:21–42

    PubMed  Google Scholar 

  15. Covington MA, He C, Brown C et al (2005) Schizophrenia and the structure of language: the linguist’s view. Schizophr Res 77:85–98

    PubMed  Google Scholar 

  16. McKenna P, Oh T (2005) Schizophrenic speech: making sense of bathroots and ponds that fall in doorways. Cambridge University Press, New York, NY

    Google Scholar 

  17. Bora E, Yücel M, Pantelis C (2009) Theory of mind impairment: a distinct trait-marker for schizophrenia spectrum disorders and bipolar disorder? Acta Psychiatr Scand 120:253–264

    CAS  PubMed  Google Scholar 

  18. Fett AK, Viechtbauer W, Dominguez MD et al (2011) The relationship between neurocognition and social cognition with functional outcomes in schizophrenia: a meta-analysis. Neurosci Biobehav Rev 35:573–588

    Google Scholar 

  19. Cunill R, Castells X, Simeon D (2009) Relationships between obsessive-compulsive symptomatology and severity of psychosis in schizophrenia: a systematic review and meta-analysis. J Clin Psychiatry 70:70–82

    PubMed  Google Scholar 

  20. Jacob S, Landeros-Weisenberger A, Leckman JF (2009) Autism spectrum and obsessive-compulsive disorders: OC behaviors, phenotypes and genetics. Autism Res 2:293–311

    PubMed  Google Scholar 

  21. Konstantareas MM, Hewitt T (2001) Autistic disorder and schizophrenia: diagnostic overlaps. J Autism Dev Disord 31:19–28

    CAS  PubMed  Google Scholar 

  22. Sheitman BB, Kraus JE, Bodfish JW et al (2004) Are the negative symptoms of schizophrenia consistent with an autistic spectrum illness? Schizophr Res 69:119–120

    PubMed  Google Scholar 

  23. Hurst RM, Nelson-Gray RO, Mitchell JT et al (2007) The relationship of Asperger’s characteristics and schizotypal personality traits in a non-clinical adult sample. J Autism Dev Disord 37:1711–1720

    PubMed  Google Scholar 

  24. Esterberg ML, Trotman HD, Brasfield JL et al (2008) Childhood and current autistic features in adolescents with schizotypal personality disorder. Schizophr Res 104:265–273

    PubMed  Google Scholar 

  25. Couture SM, Penn DL, Losh M et al (2010) Comparison of social cognitive functioning in schizophrenia and high functioning autism: more convergence than divergence. Psychol Med 40:569–579

    PubMed  Google Scholar 

  26. Roy MA, Maziade M, Labbé A et al (2001) Male gender is associated with deficit schizophrenia: a meta-analysis. Schizophr Res 47:141–147

    CAS  PubMed  Google Scholar 

  27. Sporn AL, Addington AM, Gogtay N et al (2004) Pervasive developmental disorder and childhood-onset schizophrenia: comorbid disorder or a phenotypic variant of a very early onset illness? Biol Psychiatry 55:989–994

    PubMed  Google Scholar 

  28. Reaven JA, Hepburn SL, Ross RG (2008) Use of the ADOS and ADI-R in children with psychosis: importance of clinical judgment. Clin Child Psychol Psychiatry 13:81–94

    PubMed  Google Scholar 

  29. Hurley RS, Losh M, Parlier M et al (2007) The broad autism phenotype questionnaire. J Autism Dev Disord 37:1679–1690

    PubMed  Google Scholar 

  30. Venables PH, Wilkins S, Mitchell DA et al (1990) A scale for the measurement of schizotypy. Pers Individ Diff 11:481–495

    Google Scholar 

  31. Raine A, Benishay D (1995) The SPQ-B: a brief screening instrument for schizotypal personality disorder. J Pers Disord 9:346–355

    Google Scholar 

  32. Wuthrich VM, Bates TC (2006) Confirmatory factor analysis of the three-factor structure of the schizotypal personality questionnaire and Chapman schizotypy scales. J Pers Assess 87:292–304

    PubMed  Google Scholar 

  33. Sugihara G, Tsuchiya KJ, Takei N (2008) Distinguishing broad autism phenotype from schizophrenia-spectrum disorders. J Autism Dev Disord 38:1998–1999

    PubMed  Google Scholar 

  34. Baker KD, Skuse DH (2005) Adolescents and young adults with 22q11 deletion syndrome: psychopathology in an at-risk group. Br J Psychiatry 186:115–120

    PubMed  Google Scholar 

  35. DeLisi LE, Maurizio AM, Svetina C et al (2005) Klinefelter’s syndrome (XXY) as a genetic model for psychotic disorders. Am J Med Genet B Neuropsychiatr Genet 135B:15–23

    PubMed  Google Scholar 

  36. Antshel KM, Aneja A, Strunge L et al (2007) Autistic spectrum disorders in velo-cardio facial syndrome (22q11.2 deletion). J Autism Dev Disord 37:1776–1786

    PubMed  Google Scholar 

  37. Dimitropoulos A, Schultz RT (2007) Autistic-like symptomatology in Prader-Willi syndrome: a review of recent findings. Curr Psychiatry Rep 9:159–164

    PubMed  Google Scholar 

  38. Jha P, Sheth D, Ghaziuddin M (2007) Autism spectrum disorder and Klinefelter syndrome. Eur Child Adolesc Psychiatry 16:305–308

    CAS  PubMed  Google Scholar 

  39. van Rijn S, Swaab H, Aleman A et al (2008) Social behavior and autism traits in a sex chromosomal disorder: Klinefelter (47XXY) syndrome. J Autism Dev Disord 38:1634–1641

    PubMed  Google Scholar 

  40. Soni S, Whittington J, Holland AJ et al (2008) The phenomenology and diagnosis of psychiatric illness in people with Prader-Willi syndrome. Psychol Med 38:1505–1514

    CAS  PubMed  Google Scholar 

  41. Webb T, Maina EN, Soni S et al (2008) In search of the psychosis gene in people with Prader-Willi syndrome. Am J Med Genet A 146:843–853

    PubMed  Google Scholar 

  42. Bruining H, de Sonneville L, Swaab H et al (2010) Dissecting the clinical heterogeneity of autism spectrum disorders through defined genotypes. PLoS One 5:e10887

    PubMed  Google Scholar 

  43. Karayiorgou M, Simon TJ, Gogos JA (2010) 22q11.2 microdeletions: linking DNA structural variation to brain dysfunction and schizophrenia. Nat Rev Neurosci 11:402–416

    CAS  PubMed  Google Scholar 

  44. Crespi B, Badcock C (2008) Psychosis and autism as diametrical disorders of the social brain. Behav Brain Sci 31:241–261, discussion 261–320

    PubMed  Google Scholar 

  45. Crespi B, Summers K, Dorus S (2009) Genomic sister-disorders of neurodevelopment: an evolutionary approach. Evol Appl 2:81–100

    Google Scholar 

  46. Jones P (1997) The early origins of schizophrenia. Br Med Bull 53:135–155

    CAS  PubMed  Google Scholar 

  47. Sobin C, Blundell ML, Conry A et al (2001) Early, non-psychotic deviant behavior in schizophrenia: a possible endophenotypic marker for genetic studies. Psychiatry Res 101:101–113

    CAS  PubMed  Google Scholar 

  48. Schenkel LS, Silverstein SM (2004) Dimensions of premorbid functioning in schizophrenia: a review of neuromotor, cognitive, social, and behavioral domains. Genet Soc Gen Psychol Monogr 130:241–270

    PubMed  Google Scholar 

  49. Eliez S (2007) Autism in children with 22q11.2 deletion syndrome. J Am Acad Child Adolesc Psychiatry 46:433–434

    PubMed  Google Scholar 

  50. Monte RC, Goulding SM, Compton MT (2008) Premorbid functioning of patients with first-episode nonaffective psychosis: a comparison of deterioration in academic and social performance, and clinical correlates of Premorbid Adjustment Scale scores. Schizophr Res 104:206–213

    PubMed  Google Scholar 

  51. Tarbox SI, Pogue-Geile MF (2008) Development of social functioning in preschizophrenia children and adolescents: a systematic review. Psychol Bull 134:561–583

    PubMed  Google Scholar 

  52. Saracco-Alvarez R, Rodríguez-Verdugo S, García-Anaya M et al (2009) Premorbid adjustment in schizophrenia and schizoaffective disorder. Psychiatry Res 165:234–240

    PubMed  Google Scholar 

  53. Tandon R, Nasrallah HA, Keshavan MS (2009) Schizophrenia, “just the facts” 4. Clinical features and conceptualization. Schizophr Res 110:1–23

    PubMed  Google Scholar 

  54. Keshavan MS, Kulkarni S, Bhojraj T et al (2010) Premorbid cognitive deficits in young relatives of schizophrenia patients. Front Hum Neurosci 3:62

    PubMed  Google Scholar 

  55. Feinstein C, Singh S (2007) Social phenotypes in neurogenetic syndromes. Child Adolesc Psychiatr Clin N Am 16:631–647

    PubMed  Google Scholar 

  56. Shinawi M, Liu P, Kang SH et al (2010) Recurrent reciprocal 16p11.2 rearrangements associated with global developmental delay, behavioural problems, dysmorphism, epilepsy, and abnormal head size. J Med Genet 47:332–341

    CAS  PubMed  Google Scholar 

  57. Rapoport J, Chavez A, Greenstein D et al (2009) Autism spectrum disorders and childhood-onset schizophrenia: clinical and biological contributions to a relation revisited. J Am Acad Child Adolesc Psychiatry 48:10–18

    PubMed  Google Scholar 

  58. Weiss LA, Shen Y, Korn JM et al (2008) Association between microdeletion and microduplication at 16p11.2 and autism. N Engl J Med 358:667–675

    CAS  PubMed  Google Scholar 

  59. Ben-Shachar S, Lanpher B, German JR et al (2009) Microdeletion 15q13.3: a locus with incomplete penetrance for autism, mental retardation, and psychiatric disorders. J Med Genet 46:382–388

    CAS  PubMed  Google Scholar 

  60. Doornbos M, Sikkema-Raddatz B, Ruijvenkamp CA et al (2009) Nine patients with a microdeletion 15q11.2 between breakpoints 1 and 2 of the Prader-Willi critical region, possibly associated with behavioural disturbances. Eur J Med Genet 52:108–115

    PubMed  Google Scholar 

  61. McCarthy SE, Makarov V, Kirov G et al (2009) Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet 41:1223–1227

    CAS  PubMed  Google Scholar 

  62. Crespi B, Stead P, Elliot M (2010) Comparative genomics of autism and schizophrenia. Proc Natl Acad Sci USA 107(Suppl 1):1736–1741

    CAS  PubMed  Google Scholar 

  63. Kumar RA, KaraMohamed S, Sudi J et al (2008) Recurrent 16p11.2 microdeletions in autism. Hum Mol Genet 17:628–638

    CAS  PubMed  Google Scholar 

  64. Glessner JT, Wang K, Cai G et al (2009) Autism genome-wide copy number variation reveals ubiquitin and neuronal genes. Nature 459:569–573

    CAS  PubMed  Google Scholar 

  65. de Bruin EI, de Nijs PF, Verheij F et al (2007) Multiple complex developmental disorder delineated from PDD-NOS. J Autism Dev Disord 37:1181–1191

    PubMed  Google Scholar 

  66. Sprong M, Becker HE, Schothorst PF et al (2008) Pathways to psychosis: a comparison of the pervasive developmental disorder subtype multiple complex developmental disorder and the “at risk mental state”. Schizophr Res 99:38–47

    CAS  PubMed  Google Scholar 

  67. Gothelf D, Frisch A, Michaelovsky E et al (2009) Velo-cardio-facial syndrome. J Ment Health Res Intellect Disabil 2:149–167

    PubMed  Google Scholar 

  68. Kendler KS (2005) “A gene for …”: the nature of gene action in psychiatric disorders. Am J Psychiatry 162:1243–1252

    PubMed  Google Scholar 

  69. Blackwood DH, Pickard BJ, Thomson PA et al (2007) Are some genetic risk factors common to schizophrenia, bipolar disorder and depression? Evidence from DISC1, GRIK4 and NRG1. Neurotox Res 11:73–83

    CAS  PubMed  Google Scholar 

  70. Fanous AH, Kendler KS (2008) Genetics of clinical features and subtypes of schizophrenia: a review of the recent literature. Curr Psychiatry Rep 10:164–170

    PubMed  Google Scholar 

  71. Muir WJ, Pickard BS, Blackwood DH (2008) Disrupted-in-schizophrenia-1. Curr Psychiatry Rep 10:140–147

    PubMed  Google Scholar 

  72. Walters JT, Corvin A, Owen MJ et al (2010) Psychosis susceptibility gene ZNF804A and cognitive performance in schizophrenia. Arch Gen Psychiatry 67:692–700

    CAS  PubMed  Google Scholar 

  73. Van Os J (2010) Are psychiatric diagnoses of psychosis scientific and useful? The case of schizophrenia. J Ment Health 19:305–317

    PubMed  Google Scholar 

  74. Linney YM, Murray RM, Peters ER et al (2003) A quantitative genetic analysis of schizotypal personality traits. Psychol Med 33:803–816

    CAS  PubMed  Google Scholar 

  75. Schürhoff F, Laguerre A, Szöke A et al (2005) Schizotypal dimensions: continuity between schizophrenia and bipolar disorders. Schizophr Res 80:235–242

    PubMed  Google Scholar 

  76. Happé F, Ronald A, Plomin R (2006) Time to give up on a single explanation for autism. Nat Neurosci 9:1218–1220

    PubMed  Google Scholar 

  77. Ronald A, Larsson H, Anckarsäter H et al (2010) A twin study of autism symptoms in Sweden. Mol Psychiatry (in press)

    Google Scholar 

  78. Mandy WP, Skuse DH (2008) What is the association between the social-communication element of autism and repetitive interests, behaviours and activities? J Child Psychol Psychiatry 49:795–808

    PubMed  Google Scholar 

  79. Soulières I, Dawson M, Samson F et al (2009) Enhanced visual processing contributes to matrix reasoning in autism. Hum Brain Mapp 30:4082–4107

    PubMed  Google Scholar 

  80. Russell-Smith SN, Maybery MT, Bayliss DM (2010) Are the autism and positive schizotypy spectra diametrically opposed in local versus global processing? J Autism Dev Disord 40:968–977

    PubMed  Google Scholar 

  81. Mottron L, Dawson M, Soulières I (2009) Enhanced perception in savant syndrome: patterns, structure and creativity. Philos Trans R Soc Lond B Biol Sci 364:1385–1391

    PubMed  Google Scholar 

  82. Happé F, Vital P (2009) What aspects of autism predispose to talent? Philos Trans R Soc Lond B Biol Sci 364:1369–1375

    PubMed  Google Scholar 

  83. Newman TM, Macomber D, Naples AJ et al (2007) Hyperlexia in children with autism spectrum disorders. J Autism Dev Disord 37:760–774

    PubMed  Google Scholar 

  84. Dawson M, Soulières I, Gernsbacher MA et al (2007) The level and nature of autistic intelligence. Psychol Sci 18:657–662

    PubMed  Google Scholar 

  85. Hayashi M, Kato M, Igarashi K et al (2008) Superior fluid intelligence in children with Asperger’s disorder. Brain Cogn 66:306–310

    PubMed  Google Scholar 

  86. Prior M, Perry D, Gajzago C (1975) Kanner’s syndrome or early-onset psychosis: a taxonomic analysis of 142 cases. J Autism Child Schizophr 5:71–80

    CAS  PubMed  Google Scholar 

  87. Cunningham AB, Schreibman L (2008) Stereotypy in autism: the importance of function. Res Autism Spectr Disord 2:469–479

    PubMed  Google Scholar 

  88. Goldman S, Wang C, Salgado MW et al (2009) Motor stereotypies in children with autism and other developmental disorders. Dev Med Child Neurol 51:30–38

    PubMed  Google Scholar 

  89. Bonnel A, McAdams S, Smith B et al (2010) Enhanced pure-tone pitch discrimination among persons with autism but not asperger syndrome. Neuropsychologia 48:2465–2475

    PubMed  Google Scholar 

  90. Ashwin E, Ashwin C, Rhydderch D et al (2009) Eagle-eyed visual acuity: an experimental investigation of enhanced perception in autism. Biol Psychiatry 65:17–21

    PubMed  Google Scholar 

  91. Mottron L, Dawson M, Soulières I et al (2006) Enhanced perceptual functioning in autism: an update, and eight principles of autistic perception. J Autism Dev Disord 36:27–43

    PubMed  Google Scholar 

  92. Scott MM, Deneris ES (2005) Making and breaking serotonin neurons and autism. Int J Dev Neurosci 23:277–285

    CAS  PubMed  Google Scholar 

  93. Whitaker-Azmitia PM (2005) Behavioral and cellular consequences of increasing serotonergic activity during brain development: a role in autism? Int J Dev Neurosci 23:75–83

    CAS  PubMed  Google Scholar 

  94. Mraz KD, Dixon J, Dumont-Mathieu T et al (2009) Accelerated head and body growth in infants later diagnosed with autism spectrum disorders: a comparative study of optimal outcome children. J Child Neurol 24:833–845

    PubMed  Google Scholar 

  95. Redcay E, Courchesne E (2005) When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biol Psychiatry 58:1–9

    PubMed  Google Scholar 

  96. Herbert MR, Ziegler DA, Deutsch CK et al (2003) Dissociations of cerebral cortex, subcortical and cerebral white matter volumes in autistic boys. Brain 126:1182–1192

    CAS  PubMed  Google Scholar 

  97. Bigler ED, Abildskov TJ, Petrie JA et al (2010) Volumetric and voxel-based morphometry findings in autism subjects with and without macrocephaly. Dev Neuropsychol 35:278–295

    PubMed  Google Scholar 

  98. Fanous A, Gardner C, Walsh D et al (2001) Relationship between positive and negative symptoms of schizophrenia and schizotypal symptoms in nonpsychotic relatives. Arch Gen Psychiatry 58:669–673

    CAS  PubMed  Google Scholar 

  99. Skuse DH, Mandy WP, Scourfield J (2005) Measuring autistic traits: heritability, reliability and validity of the social and communication disorders checklist. Br J Psychiatry 187:568–572

    PubMed  Google Scholar 

  100. Fanous AH, Neale MC, Gardner CO et al (2007) Significant correlation in linkage signals from genome-wide scans of schizophrenia and schizotypy. Mol Psychiatry 12:958–965

    CAS  PubMed  Google Scholar 

  101. Abrahams BS, Geschwind DH (2008) Advances in autism genetics: on the threshold of a new neurobiology. Nat Rev Genet 9:341–355

    CAS  PubMed  Google Scholar 

  102. Weiss LA (2009) Autism genetics: emerging data from genome-wide copy-number and single nucleotide polymorphism scans. Expert Rev Mol Diagn 9:795–803

    CAS  PubMed  Google Scholar 

  103. Owen MJ, Craddock N, O’Donovan MC (2010) Suggestion of roles for both common and rare risk variants in genome-wide studies of schizophrenia. Arch Gen Psychiatry 67:667–673

    CAS  PubMed  Google Scholar 

  104. Nesse RM (2004) Cliff-edged fitness functions and the persistence of schizophrenia. Behav Brain Sci 27:862–863

    Google Scholar 

  105. Jung RE, Grazioplene R, Caprihan A et al (2010) White matter integrity, creativity, and psychopathology: disentangling constructs with diffusion tensor imaging. PLoS One 5:e9818

    PubMed  Google Scholar 

  106. Brüne M, Brüne-Cohrs U (2006) Theory of mind – evolution, ontogeny, brain mechanisms and psychopathology. Neurosci Biobehav Rev 30:437–455

    PubMed  Google Scholar 

  107. Burns JK (2006) Psychosis: a costly by-product of social brain evolution in homo sapiens. Prog Neuropsychopharmacol Biol Psychiatry 30:797–814

    PubMed  Google Scholar 

  108. Frith CD (2008) Social cognition. Philos Trans R Soc Lond B Biol Sci 363:2033–2039

    PubMed  Google Scholar 

  109. Keller MC, Nesse RM (2006) The evolutionary significance of depressive symptoms: different adverse situations lead to different depressive symptom patterns. J Pers Soc Psychol 91:316–330

    PubMed  Google Scholar 

  110. Jansen A, Krach S, Krug A et al (2009) A putative high risk diplotype of the G72 gene is in healthy individuals associated with better performance in working memory functions and altered brain activity in the medial temporal lobe. Neuroimage 45:1002–1008

    PubMed  Google Scholar 

  111. Kircher T, Krug A, Markov V et al (2009) Genetic variation in the schizophrenia-risk gene neuregulin 1 correlates with brain activation and impaired speech production in a verbal fluency task in healthy individuals. Hum Brain Mapp 30:3406–3416

    PubMed  Google Scholar 

  112. Manolio TA, Collins FS, Cox NJ et al (2009) Finding the missing heritability of complex diseases. Nature 461:747–753

    CAS  PubMed  Google Scholar 

  113. Hennah W, The PD (2009) DISC1 pathway modulates expression of neurodevelopmental, synaptogenic and sensory perception genes. PLoS One 4:e4906

    PubMed  Google Scholar 

  114. Craddock N, O’Donovan MC, Owen MJ (2005) The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J Med Genet 42:193–204

    CAS  PubMed  Google Scholar 

  115. O’Donovan MC, Craddock NJ, Owen MJ (2009) Genetics of psychosis; insights from views across the genome. Hum Genet 126:3–12

    PubMed  Google Scholar 

  116. Craddock N, O’Donovan MC, Owen MJ (2009) Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or “schizoaffective”) psychoses. Schizophr Bull 35:482–490

    PubMed  Google Scholar 

  117. Craddock N, Owen MJ (2010) The Kraepelinian dichotomy – going, going … but still not gone. Br J Psychiatry 196:92–95

    PubMed  Google Scholar 

  118. Petty LK, Ornitz EM, Michelman JD et al (1984) Autistic children who become schizophrenic. Arch Gen Psychiatry 41:129–135

    CAS  PubMed  Google Scholar 

  119. Goldstein G, Minshew NJ, Allen DN et al (2002) High-functioning autism and schizophrenia: a comparison of an early and late onset neurodevelopmental disorder. Arch Clin Neuropsychol 17:461–475

    PubMed  Google Scholar 

  120. Solomon M, Ozonoff S, Carter C et al (2008) Formal thought disorder and the autism spectrum: relationship with symptoms, executive control, and anxiety. J Autism Dev Disord 38:1474–1484

    PubMed  Google Scholar 

  121. Kanner L (1949) Problems of nosology and psychodynamics of early infantile autism. Am J Orthopsychiatry 19:416–426

    CAS  PubMed  Google Scholar 

  122. Frith CD, Frith U (1991) Elective affinities in schizophrenia and childhood autism. In: Bebbington P (ed) Social psychiatry: theory, methodology and practice. Transactions Press, New Brunswick, NJ, pp 65–88

    Google Scholar 

  123. Kanner L (1965) Infantile autism and the schizophrenias. Behav Sci 10:412–420

    CAS  PubMed  Google Scholar 

  124. Badcock C (2009) The imprinted brain: how genes set the balance between autism and psychosis. Jessica Kingsley Publishers, London, UK

    Google Scholar 

  125. Murray GK, Corlett PR, Clark L et al (2008) Substantia nigra/ventral tegmental reward prediction error disruption in psychosis. Mol Psychiatry 13(239):267–276

    CAS  Google Scholar 

  126. Woodward TS, Munz M, LeClerc C et al (2009) Change in delusions is associated with change in “jumping to conclusions”. Psychiatry Res 170:124–127

    PubMed  Google Scholar 

  127. Ford JM, Roach BJ, Faustman WO et al (2008) Out-of-synch and out-of-sorts: dysfunction of motor-sensory communication in schizophrenia. Biol Psychiatry 63:736–743

    PubMed  Google Scholar 

  128. Taylor JG (2010) A neural model of the loss of self in schizophrenia. Schizophr Bull (in press)

    Google Scholar 

  129. Iossifov I, Zheng T, Baron M et al (2008) Genetic-linkage mapping of complex hereditary disorders to a whole-genome molecular-interaction network. Genome Res 18:1150–1162

    CAS  PubMed  Google Scholar 

  130. Burbach JP, van der Zwaag B (2009) Contact in the genetics of autism and schizophrenia. Trends Neurosci 32:69–72

    CAS  PubMed  Google Scholar 

  131. Matson JL, Shoemaker M (2009) Intellectual disability and its relationship to autism spectrum disorders. Res Dev Disabil 30:1107–1114

    PubMed  Google Scholar 

  132. Bora E, Yücel M, Pantelis C (2010) Cognitive impairment in schizophrenia and affective psychoses: implications for DSM-V criteria and beyond. Schizophr Bull 36:36–42

    PubMed  Google Scholar 

  133. Skuse DH (2007) Rethinking the nature of genetic vulnerability to autistic spectrum disorders. Trends Genet 23:387–395

    CAS  PubMed  Google Scholar 

  134. Prasad KM, Keshavan MS (2008) Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct “extended endophenotypes”? Schizophr Bull 34:774–790

    PubMed  Google Scholar 

  135. Tan HY, Callicott JH, Weinberger DR (2008) Intermediate phenotypes in schizophrenia genetics redux: is it a no brainer? Mol Psychiatry 13:233–238

    CAS  PubMed  Google Scholar 

  136. Allen AJ, Griss ME, Folley BS et al (2009) Endophenotypes in schizophrenia: a selective review. Schizophr Res 109:24–37

    PubMed  Google Scholar 

  137. Kendler KS, Neale MC (2010) Endophenotype: a conceptual analysis. Mol Psychiatry 15:789–797

    Google Scholar 

  138. White S, O’Reilly H, Frith U (2009) Big heads, small details and autism. Neuropsychologia 47:1274–1281

    PubMed  Google Scholar 

  139. Berry-Kravis E, Hessl D, Coffey S et al (2009) A pilot open label, single dose trial of fenobam in adults with fragile X syndrome. J Med Genet 46:266–271

    CAS  PubMed  Google Scholar 

  140. Conn PJ, Lindsley CW, Jones CK (2009) Activation of metabotropic glutamate receptors as a novel approach for the treatment of schizophrenia. Trends Pharmacol Sci 30:25–31

    CAS  PubMed  Google Scholar 

  141. Lippiello PM (2006) Nicotinic cholinergic antagonists: a novel approach for the treatment of autism. Med Hypotheses 66:985–990

    CAS  PubMed  Google Scholar 

  142. Olincy A, Harris JG, Johnson LL et al (2006) Proof-of-concept trial of an alpha7 nicotinic agonist in schizophrenia. Arch Gen Psychiatry 63:630–638

    CAS  PubMed  Google Scholar 

  143. Kendler KS (2009) An historical framework for psychiatric nosology. Psychol Med 39:1935–1941

    PubMed  Google Scholar 

  144. Ehninger D, Li W, Fox K et al (2008) Reversing neurodevelopmental disorders in adults. Neuron 60:950–960

    CAS  PubMed  Google Scholar 

  145. Cannon TD (2009) What is the role of theories in the study of schizophrenia? Schizophr Bull 35:563–567

    PubMed  Google Scholar 

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Acknowledgements

I am grateful to NSERC for financial support, and to C. Badcock and N. Craddock for discussions.

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  1. Department of Biosciences, Simon Fraser University, Burnaby, BC, Canada

    Bernard J. Crespi

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  1. Bernard J. Crespi
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Correspondence to Bernard J. Crespi .

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  1. Sha'ar Menashe Mental Health Center, Hadera, 38814, Israel

    Michael S. Ritsner

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Crespi, B.J. (2011). One Hundred Years of Insanity: Genomic, Psychological, and Evolutionary Models of Autism in Relation to Schizophrenia. In: Ritsner, M. (eds) Handbook of Schizophrenia Spectrum Disorders, Volume I. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0837-2_7

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