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Cell Fusion, Drug Resistance and Recurrence CSCs

  • Christa Nagler
  • Kurt S. Zänker
  • Thomas DittmarEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 950)

Abstract

Cancer stem cells (CSCs) are a rare population of cancer cells exhibiting stem cell properties, such as self-renewal, differentiation and tissue restoration. Beside the initiation of the primary tumor, CSCs have also been associated with metastasis formation and cancer relapses. In the context of cancer relapses, we have recently postulated the existence of so-called recurrence CSCs (rCSCs). These specific CSC subtype will initiate relapses exhibiting an “oncogenic resistance” phenotype, which are characterized by a markedly increased malignancy concomitant with a drug resistance towards first line therapy. In the present chapter we will discuss the necessity of rCSCs as a distinct CSC subtype and that cell fusion could be one mechanism how rCSCs could originate.

Keywords

Chronic Myeloid Leukemia Cell Fusion Hybrid Cell Fusion Partner Side Population Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

This work was supported by the “Verein zur Förderung der Krebsforschung e.V.”, Heidelberg, Germany and the Fritz-Bender-Foundation, Munich, Germany.

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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Christa Nagler
    • 1
  • Kurt S. Zänker
    • 1
  • Thomas Dittmar
    • 1
    • 2
    Email author
  1. 1.Institute of Immunology, Witten/Herdecke UniversityWittenGermany
  2. 2.Zentrum für Biomedizinische Ausbildung und Forschung an der UWH (ZBAF), Witten/Herdecke University, Institute of ImmunologyWittenGermany

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