Cell Fusion Hypothesis of the Cancer Stem Cell

  • Xin Lu
  • Yibin KangEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 950)


A major advance in recent cancer research is the identification of tumor cells with stem cell-like properties. Cancer stem cells (CSCs) often represent a rare population in the tumor mass and possess the exclusive ability to initiate the growth of a heterogeneous tumor. The origin of CSCs remains elusive and is likely to be cancer type specific. One possible but under-appreciated potential mechanism for the generation of CSCs is through fusion between stem cells and differentiated cells. The cell fusion hypothesis of CSCs adds an important functional underpinning to the potential multifaceted roles of cell fusion in the initiation and progression of cancer.


Cell Fusion Fusion Partner Somatic Stem Cell Transplant Bone Marrow Cell Supernumerary Centrosome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  1. 1.Department of Molecular BiologyPrinceton UniversityPrincetonUSA
  2. 2.Breast Cancer ProgramThe Cancer Institute of New JerseyNew BrunswickUSA

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