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Function of Tenascins in the Tumor Stroma

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Tumor-Associated Fibroblasts and their Matrix

Part of the book series: The Tumor Microenvironment ((TTME,volume 4))

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Abstract

In 1983, Bourdon et al. (Cancer Res 43:2796–2805, 1983) first described glioma-mesenchymal extracellular matrix (GMEM) antigen. Shortly thereafter it became clear that GMEM antigen, now known as tenascin-C, was expressed not only in brain tumors but also in rat mammary tumors (Chiquet-Ehrismann et al., Cell 47:131–139, 1986) and in human breast cancer (Mackie et al., Proc Natl Acad Sci U S A 84:4621–4625, 1987). Work that followed demonstrated that tenascin-C was, in fact, overexpressed in almost all solid tumors (for review see Orend and Chiquet-Ehrismann, Cancer Lett 244:143–163, 2006).

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Authors and Affiliations

  1. Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Maulbeerstrasse 66, 4058, Basel, Switzerland

    Florence Brellier & Ruth Chiquet-Ehrismann

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  1. Florence Brellier
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  2. Ruth Chiquet-Ehrismann
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Correspondence to Ruth Chiquet-Ehrismann .

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  1. Siederstrasse 13, Villingen-Schwenningen, 78054, Germany

    Margareta M. Mueller

  2. Am Pferchelhang 32, Heidelberg, 69118, Germany

    Norbert E. Fusenig

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Brellier, F., Chiquet-Ehrismann, R. (2011). Function of Tenascins in the Tumor Stroma. In: Mueller, M., Fusenig, N. (eds) Tumor-Associated Fibroblasts and their Matrix. The Tumor Microenvironment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0659-0_8

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