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Cancer Associated Fibroblasts as Therapeutic Targets

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Tumor-Associated Fibroblasts and their Matrix

Part of the book series: The Tumor Microenvironment ((TTME,volume 4))

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Abstract

The tumor stroma plays an important role in tumorigenesis. During cancer progression the tumor stroma undergoes changes in architecture, gene expression, secretion of soluble factors and extracellular matrix deposition that are essential for the malignant epithelial cells to manifest the invasive and metastatic phenotype of malignant tumors. Altered gene expression in these non-transformed stromal cells has provided potential targets for therapy. Assessing the therapeutic utility of this new class of drugs requires the use of in vitro and in vivo tumor models that recapitulate the complex molecular and structural interactions between the malignant cells and the surrounding stroma. Appropriate in vivo models are also needed that are suitable to determine the efficacy and tolerability of the drugs. Considerable advances have been made in this respect and a number of drugs targeting signalling pathways of activated tumor fibroblasts are in clinical development.

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Authors and Affiliations

  1. Boehringer Ingelheim RCV GmbH & Co KG, Dr. Boehringer-Gasse 5–11, 1130, Vienna, Austria

    Christian Haslinger, Norbert Schweifer & Pilar Garin-Chesa

  2. Institute of Pathology, Medical University of Vienna, Waehringer Guertel 18–20, 1090, Vienna, Austria

    Christian Rupp, Helmut Dolznig & Pilar Garin-Chesa

  3. Institute of Medical Genetics, Centre of Pathobiology and Genetics, Medical University of Vienna, Waehringer Strasse 10, 1090, Vienna, Austria

    Helmut Dolznig

Authors
  1. Christian Rupp
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  2. Helmut Dolznig
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  3. Christian Haslinger
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  4. Norbert Schweifer
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  5. Pilar Garin-Chesa
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Corresponding author

Correspondence to Pilar Garin-Chesa .

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Editors and Affiliations

  1. Siederstrasse 13, Villingen-Schwenningen, 78054, Germany

    Margareta M. Mueller

  2. Am Pferchelhang 32, Heidelberg, 69118, Germany

    Norbert E. Fusenig

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Rupp, C., Dolznig, H., Haslinger, C., Schweifer, N., Garin-Chesa, P. (2011). Cancer Associated Fibroblasts as Therapeutic Targets. In: Mueller, M., Fusenig, N. (eds) Tumor-Associated Fibroblasts and their Matrix. The Tumor Microenvironment, vol 4. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0659-0_20

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