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Tumors of the Central Nervous System, Volume 2 pp 25–29Cite as

Molecular Subtypes of Gliomas

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Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 2))

Abstract

Gliomas are the most common primary brain tumors with heterogeneous morphology and variable prognosis. However, differences between histological subclasses and grades are subtle, and classifying gliomas is subject to a large inter-observer variability. This variability can result in misdiagnosis of gliomas. As treatment decisions in patients rely mainly on histological classification and clinical parameters, there is an urgent need of developing a more accurate and objective classification model. The identification of specific molecular markers (LOH of 1p19q, IDH1 mutation, MGMT methylation status), as well as molecular clusters based on gene expression have been studied extensively. These specific molecular features within gliomas can help diagnosis, can give a more accurate prognosis, and may also be used to develop personalized targeted therapy in the future.

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Authors and Affiliations

  1. Department of Neurology, Josephine Nefkens Institute, Erasmus Medical Centre, Rotterdam, The Netherlands

    Lonneke A.M. Gravendeel

  2. Department of Neurology, Josephine Nefkens Institute, Erasmus Medical Centre, 3000, DR, Rotterdam, The Netherlands

    Pim J. French

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  1. Lonneke A.M. Gravendeel
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  2. Pim J. French
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Correspondence to Pim J. French .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Gravendeel, L.A., French, P.J. (2011). Molecular Subtypes of Gliomas. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 2. Tumors of the Central Nervous System, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0618-7_3

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  • DOI: https://doi.org/10.1007/978-94-007-0618-7_3

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