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Gliomagenesis: Advantages and Limitations of Biomarkers

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Tumors of the Central Nervous System, Volume 2

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 2))

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Abstract

During the last years, spectacular progress in the field of molecular biology raised the hope that it might replace or at least improve significantly the World Health Organization classification of tumors of the central nervous system. Although up to now, this has not been the case, a few biomarkers have found their place as prognostic factors for certain tumor types on the one hand, and as predictive factors of response to treatments on the other hand. The present chapter will deal with the following tumor types: astrocytic tumors (including Diffuse astrocytoma, Anaplastic astrocytoma, Glioblastoma, and Pilocytic astrocytoma), Oligodendroglial tumours (including Oligodendroglioma and Anaplastic oligodendroglioma), and mixed gliomas (including Oligoastrocytoma and Anaplastic oligodendroglioma). The current biomarkers are not decision-making parameters on a case by case basis, but they have progressively emerged as cornerstone indicators as far as stratification in clinical studies is concerned. As a consequence, during therapeutic trials, it can be considered that groups of patients whose biomarkers anticipate a poor response to standard treatment might be offered the opportunity of innovative therapies. In this context, the most recent developments of molecular biology culminating in integrated molecular analysis of tumors and the possibilities offered by neurosphere cultures established from glioblastoma multiforme that recapitulate the tumor allow to anticipate a growing importance of a series of new biomarker in the years to come.

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Authors and Affiliations

  1. Poitiers University Hospital, University of Poitiers Medical School, EA 3805, Poitiers, France

    Michel Wager & Christian-Jacques Larsen

  2. Department of Molecular Biology, Poitiers University Hospital, University of Poitiers Medical School, Poitiers, France

    Lucie Karayan-Tapon

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  1. Michel Wager
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  2. Lucie Karayan-Tapon
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  3. Christian-Jacques Larsen
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Correspondence to Michel Wager .

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  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Wager, M., Karayan-Tapon, L., Larsen, CJ. (2011). Gliomagenesis: Advantages and Limitations of Biomarkers. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 2. Tumors of the Central Nervous System, vol 2. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0618-7_2

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  • DOI: https://doi.org/10.1007/978-94-007-0618-7_2

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