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Breast Cancer, a Heterogeneous Disease Entity pp 89–117Cite as

The Molecular Evolution of Breast Cancer Precursors and Risk Indicators

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Abstract

The greater availability of data on the molecular features of benign breast lesions and breast cancer precursor lesion has changed our perception of the pathways of breast cancer progression. It is evident that breast cancer can be classified into distinct entities on the basis of ER expression; the type and pattern of genetic aberrations found in ER positive cancers are distinct from those found in ER negative cancers. Furthermore, the pattern and complexity of genetic aberrations found in ER positive cancers is associated with histological grade. Furthermore, some of the hallmark genetic aberrations typically found in low grade ER positive breast cancers (i.e. gains of 1q coupled with deletions of 16q) have been identified in a significant subset of high grade ER positive breast cancers. This suggests that at least a subset of high grade ER positive breast cancers may originate from low grade lesions. In contrast, ER negative cancers are more heterogeneous, but do not harbour the hallmark genetic aberrations usually found in low grade breast cancers. In this chapter, we address the molecular features of breast cancer risk indicators and breast cancer precursor lesions, discuss the mechanisms of progression from in situ to invasive disease and propose an updated model of breast cancer evolution.

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Authors and Affiliations

  1. Molecular Pathology Team, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, SW3 6JB, London, UK

    Paul M. Wilkerson, Konstantin J. Dedes, Maria A. Lopez-Garcia, Felipe C. Geyer & Jorge S. Reis-Filho

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  1. Paul M. Wilkerson
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  2. Konstantin J. Dedes
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  3. Maria A. Lopez-Garcia
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  4. Felipe C. Geyer
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  5. Jorge S. Reis-Filho
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Correspondence to Jorge S. Reis-Filho .

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  1. , University of Szeged, Department of Oncotherapy, Korányi fasor 12, Szeged, 6720, Hungary

    Zsuzsanna Kahán

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Wilkerson, P.M., Dedes, K.J., Lopez-Garcia, M.A., Geyer, F.C., Reis-Filho, J.S. (2011). The Molecular Evolution of Breast Cancer Precursors and Risk Indicators. In: Kahán, Z. (eds) Breast Cancer, a Heterogeneous Disease Entity. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0489-3_5

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