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Large-Format Histology, a Prerequisite for Adequate Assessment of Early Breast Carcinomas

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Breast Cancer, a Heterogeneous Disease Entity

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Abstract

Breast carcinoma develops in an environment of genetic alterations (a sick lobe) within the breast and already exhibits a complex subgross morphology in the early stages of development in many cases. The conventional histology sampling technique applied in most laboratories today is insufficient to document this complexity in operative breast specimens. This has necessitated the special approach of using large-format histology slides, which has repeatedly demonstrated advantages in the assessment of the extent of the disease, the lesion distribution, and intratumoural and intertumoural heterogeneity and in documenting tumour size and circumferential surgical margins. The method, involving a detailed radiological–pathological correlation is, currently the only way to achieve a correct interpretation of the findings in modern breast pathology.

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Authors and Affiliations

  1. Department of Pathology, Central Hospital Falun, Uppsala University, 79182, Falun, Sweden

    Tibor Tot

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  1. Tibor Tot
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Correspondence to Tibor Tot .

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  1. , University of Szeged, Department of Oncotherapy, Korányi fasor 12, Szeged, 6720, Hungary

    Zsuzsanna Kahán

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Tot, T. (2011). Large-Format Histology, a Prerequisite for Adequate Assessment of Early Breast Carcinomas. In: Kahán, Z. (eds) Breast Cancer, a Heterogeneous Disease Entity. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0489-3_4

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