Abstract
The human gut is colonized by a large number of micro-organisms that mainly occupy the ileum and colon. This complex microbial ecosystem known as the enteric microbiota maintains a large variety of physiological functions that exerts both harmful and beneficial effects on human health. The stability of this microbiota is crucial because various disease states are associated with its imbalance. Enteric microbiota alterations may also be involved in the inflammatory responses seen in allergic and inflammatory bowel diseases. Probiotics are thought to improve resistance to intestinal infections by preventing the growth of potentially harmful bacteria and improving the immune response. They must be continuously ingested to achieve an exogenous probiotic effect. The persistence of a probiotic depends on its interaction with the enteric microbiota as well as with the immune system. Probiotics could minimize disturbances of the enteric microbiota following an antibiotic treatment. Probiotics could also be appropriate for alleviating inflammatory bowel disease symptoms and stabilizing the intestinal microbiota. Finally, probiotics act on a wide variety of cells in the intestine to modulate the immune system towards pro- or anti-inflammatory action.
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References
Alam S, Mushtaq M (2009) Antibiotic associated diarrhoea in children. Indian Pediatr 46:491–496
Alander M, De Smet I, Nollet L, Verstraete W, von Wright A, Mattila-Sandholm T (1999a) The effect of probiotic strains on the microbiota of the simulator of the human intestinal microbial ecosystem (SHIME). Int J Food Microbiol 46:71–79
Alander M, Satokari R, Korpela R, Saxelin M, Vilpponen-Salmela T, Mattila-Sandholm T, von Wright A (1999b) Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Appl Environ Microbiol 65:351–354
Arunachalam K, Gill HS, Chandra RK (2000) Enhancement of natural immune function by dietary consumption of Bifidobacterium lactis (HN019). Eur J Clin Nutr 54:263–267
Baharav E, Mor F, Halpern M, Weinberger A (2004) Lactobacillus GG bacteria ameliorate arthritis in Lewis rats. J Nutr 134:1964–1969
Barbara G, Stanghellini V, Cremon C, De Giorgio R, Gargano L, Cogliandro R, Pallotti F, Corinaldesi R (2008) Probiotics and irritable bowel syndrome: rationale and clinical evidence for their use. J Clin Gastroenterol 42:S214–S217
Barbara G, Cremon C, Pallotti F, De Giorgio R, Stanghellini V, Corinaldesi R (2009) Postinfectious irritable bowel syndrome. J Pediatr Gastroenterol Nutr 48:S959–S957
Bibiloni R, Fedorak RN, Tannock GW, Madsen KL, Gionchetti P, Campieri M, De Simone C, Sartor RB (2005) VSL#3 probiotic-mixture induces remission in patients with active ulcerative colitis. Am J Gastroenterol 100:1539–1546
Borody TJ, Warren EF, Leis SM, Surace R, Ashman O, Siarakas S (2004) Bacteriotherapy using faecal flora: toying with human motions. J Clin Gastroenterol 38:475–483
Borruel N, Carol M, Casellas F, Antolin M, de Lara F, Espin E, Naval J, Guarner F, Malagelada JR (2002) Increased mucosal tumour necrosis factor alpha production in Crohn’s disease can be downregulated ex vivo by probiotic bacteria. Gut 51:659–664
Bouhnik Y, Pochart P, Marteau P, Arlet G, Goderel I, Rambaud JC (1992) Faecal recovery in humans of viable Bifidobacterium sp. ingested in fermented milk. Gastroenterol 102:875–878
Braat H, van den Brande J, van Tol E, Hommes D, Peppelenbosch M, van Deventer S (2004) Lactobacillus rhamnosus induces peripheral hyporesponsiveness in stimulated CD4+ T cells via modulation of dendritic cell function. Am J Clin Nutr 80:1618–1625
Brigidi P, Swennen E, Vitali B, Rossi M, Matteuzzi D (2003) PCR detection of Bifidobacterium strains and Streptococcus thermophilus in faeces of human subjects after oral bacteriotherapy and yogurt consumption. Int J Food Microbiol 81:203–209
Brouwer ML, Wolt-Plompen SA, Dubois AE, van der Heide S, Jansen DF, Hoijer MA, Kauffman HF, Duiverman EJ (2006) No effects of probiotics on atopic dermatitis in infancy: a randomized placebo-controlled trial. Clin Exp Allergy 36:899–906
Bunte C, Hertei C, Hammes WP (2000) Monitoring and survival of Lactobacillus paracasei LTH 2579 in food and the human intestinal tract. Syst Appl Microbiol 23:260–266
Carol M, Borruel N, Antolin M, Llopis M, Casellas F, Guarner F, Malagelada JR (2006) Modulation of apoptosis in intestinal lymphocytes by a probiotic bacteria in Crohn’s disease. J Leukoc Biol 79:917–922
Chiang BL, Sheih YH, Wang LH, Liao CK, Gill HS (2000) Enhancing immunity by dietary consumption of a probiotic lactic acid bacterium (Bifidobacterium lactis HN019): optimization and definition of cellular immune responses. Eur J Clin Nutr 54:849–855
Christensen HR, Frokiaer H, Pestka JJ (2002) Lactobacilli differentially modulate expression of cytokines and maturation surface markers in murine dendritic cells. J Immunol 168:171–178
Claassen E, Van Winsen R, Posno M, Boersma WJ (1995) New and safe “oral” live vaccines based on lactobacillus. Adv Exp Med Biol 371B:1553–1558
Collins J, Dunne C, Murphy L, Morrisey D, O’Mahony L, O’Sullivan E, Fitzgerald G, Kiely B, O’Sullivan G, Daly C, Marteau P, Shanahan F (2002) A randomised controlled trial of a probiotic Lactobacillus strain in healthy adults: assessment of its delivery, transit and influence on microbial flora and enteric immunity. Microbial Ecol Health Dis 14:81–89
Collins SM, Denou E, Verdu EF, Bercik P (2009) The putative role of the intestinal microbiota in the irritable bowel syndrome. Dig Liver Dis 41:850–853
De Champs C, Maroncle N, Balestrino D, Rich C, Forestier C (2003) Persistence of colonization of intestinal mucosa by a probiotic strain, Lactobacillus casei subsp. rhamnosus Lcr35, after oral consumption. J Clin Microbiol 41:1270–1273
Delves PJ, Roitt IM (2000) The immune system. First of two parts. N Engl J Med 343:37–49
Dethlefsen L, Huse S, Sogin ML, Relman DA (2008) The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing. PLoS Biol 6:e280
Dommels YEM, Kemperman RA, Zebregs YEMP, Draaisma RB, Jol A, Wolvers DAW, Vaughan EE, Albers R (2009) Survival of Lactobacillus reuteri DSM 17938 and Lactobacillus rhamnosus GG in the human gastrointestinal tract with daily consumption of a low-fat probiotic spread. Appl Environ Microbiol 75:6198–6204
Drakes M, Blanchard T, Czinn S (2004) Bacterial probiotic modulation of dendritic cells. Infect Immun 72:3299–3309
Engelbrektson A, Korzenik JR, Pittler A, Sanders ME, Klaenhammer TR, Leyer G, Kitts CL (2009) Probiotics to minimize the disruption of faecal microbiota in healthy subjects undergoing antibiotic therapy. J Med Microbiol 58:663–670
Firmesse O, Mogenet A, Bresson JL, Corthier G, Furet JP (2008) Lactobacillus rhamnosus R11 consumed in a food supplement survived human digestive transit without modifying microbiota equilibrium as assessed by real-time polymerase chain reaction. J Mol Microbiol Biotechnol 14:90–99
Folster-Holst R, Muller F, Schnopp N, Abeck D, Kreiselmaier I, Lenz T, von Ruden U, Schrezenmeir J, Christophers E, Weichenthal M (2006) Prospective, randomized controlled trial on Lactobacillus rhamnosus in infants with moderate to severe atopic dermatitis. Br J Dermatol 155:1256–1261
Frank DN, Pace NR (2008) Gastrointestinal microbiology enters the metagenomics era. Curr Opin Gastroenterol 24:4–10
Fujiwara S, Seto Y, Kimura A, Hashiba H (2001a) Establishment of orally-administered Lactobacillus gasseri SBT2055SR in the gastrointestinal tract of humans and its influence on intestinal microflora and metabolism. J Appl Microbiol 90:343–352
Fujiwara S, Seto Y, Kimura A, Hashiba H (2001b) Intestinal transit of an orally administered streptomycin-rifampicin-resistant variant of Bifidobacterium longum SBT2928: its long-term survival and effect on the intestinal microflora and metabolism. J Appl Microbiol 90:43–52
Fukushima Y, Kawata Y, Hara H, Terada A, Mitsuoka T (1998) Effect of a probiotic formula on intestinal immunoglobulin A production in healthy children. Int J Food Microbiol 42:39–44
Fukushima Y, Miyaguchi S, Yamano T, Kaburagi T, Iino H, Ushida K, Sato K (2007) Improvement of nutritional status and incidence of infection in hospitalised, enterally fed elderly by feeding of fermented milk containing probiotic Lactobacillus johnsonii La1 (NCC533). Br J Nutr 98:969–977
Garrido D, Suau A, Pochart P, Cruchet S, Gotteland M (2005) Modulation of the faecal microbiota by the intake of a Lactobacillus johnsonii La1-containing product in human volunteers. FEMS Microbiol Lett 248:249–256
Gibson DL, Vallance BA (2008) Intestinal microbiota are transiently altered during Salmonella-induced gastroenteritis. Expert Rev Gastroenterol Hepatol 2:525–529
Gill HS, Rutherfurd KJ, Cross ML (2001a) Dietary probiotic supplementation enhances natural killer cell activity in the elderly: an investigation of age-related immunological changes. J Clin Immunol 21:264–271
Gill HS, Rutherfurd KJ, Cross ML, Gopal PK (2001b) Enhancement of immunity in the elderly by dietary supplementation with the probiotic Bifidobacterium lactis HN019. Am J Clin Nutr 74:833–839
Gionchetti P, Rizzello F, Venturi A, Brigidi P, Matteuzzi D, Bazzocchi G, Poggioli G, Miglioli M, Campieri M (2000) Oral bacteriotherapy as maintenance treatment in patients with chronic pouchitis: a double-blind, placebo-controlled trial. Gastroenterol 119:305–309
Gionchetti P, Rizzello F, Helwig U, Venturi A, Lammers KM, Brigidi P, Vitali B, Poggioli G, Miglioli M, Campieri M (2003) Prophylaxis of pouchitis onset with probiotic therapy: a double-blind, placebo-controlled trial. Gastroenterol 124:1202–1209
Goldin BR, Gorbach SL, Saxelin M, Barakat S, Gualtieri L, Salminen S (1992) Survival of Lactobacillus species (strain GG) in human gastrointestinal tract. Dig Dis Sci 37:121–128
Goossens DA, Jonkers DM, Russel MG, Stobberingh EE, Stockbrugger RW (2006) The effect of a probiotic drink with Lactobacillus plantarum 299v on the bacterial composition in faeces and mucosal biopsies of rectum and ascending colon. Aliment Pharmacol Ther 23:255–263
Gosselink MP, Schouten WR, van Lieshout LM, Hop WC, Laman JD, Ruseler-van Embden JG (2004) Delay of the first onset of pouchitis by oral intake of the probiotic strain Lactobacillus rhamnosus GG. Dis Colon Rectum 47:876–884
Guandalini S (2008) Probiotics for children with diarrhoea: an update. J Clin Gastroenterol 42:S53–S57
Gueimonde M, Sakata S, Kalliomaki M, Isolauri E, Benno Y, Salminen S (2006) Effect of maternal consumption of Lactobacillus GG on transfer and establishment of faecal bifidobacterial microbiota in neonates. J Pediatr Gastroenterol Nutr 42:166–170
Guslandi M, Mezzi G, Sorghi M, Testoni PA (2000) Saccharomyces boulardii in maintenance treatment of Crohn’s disease. Dig Dis Sci 45:1462–1464
Haller D, Bode C, Hammes WP, Pfeifer AM, Schiffrin EJ, Blum S (2000) Non-pathogenic bacteria elicit a differential cytokine response by intestinal epithelial cell/leucocyte co-cultures. Gut 47:79–87
Hart AL, Lammers K, Brigidi P, Vitali B, Rizzello F, Gionchetti P, Campieri M, Kamm MA, Knight SC, Stagg AJ (2004) Modulation of human dendritic cell phenotype and function by probiotic bacteria. Gut 53:1602–1609
Hatakka K, Martio J, Korpela M, Herranen M, Poussa T, Laasanen T, Saxelin M, Vapaatalo H, Moilanen E, Korpela R (2003) Effects of probiotic therapy on the activity and activation of mild rheumatoid arthritis—a pilot study. Scand J Rheumatol 32:211–215
He T, Priebe MG, Zhong Y, Huang C, Harmsen HJ, Raangs GC, Antoine JM, Welling GW, Vonk RJ (2008) Effects of yogurt and bifidobacteria supplementation on the colonic microbiota in lactose-intolerant subjects. J Appl Microbiol 104:595–604
Helin T, Haahtela S, Haahtela T (2002) No effect of oral treatment with an intestinal bacterial strain, Lactobacillus rhamnosus (ATCC 53103), on birch-pollen allergy: a placebo-controlled double-blind study. Allergy 57:243–246
Ibnou-Zekri N, Blum S, Schiffrin EJ, von der Weid T (2003) Divergent patterns of colonization and immune response elicited from two intestinal Lactobacillus strains that display similar properties in vitro. Infect Immun 71:428–436
Isolauri E, Joensuu J, Suomalainen H, Luomala M, Vesikari T (1995) Improved immunogenicity of oral D × RRV reassortant rotavirus vaccine by Lactobacillus casei GG. Vaccine 13:310–312
Isolauri E, Arvola T, SÜtas Y, Moilanen E, Salminen S (2000) Probiotics in the management of atopic eczema. Clin Exp Allergy 30:1605–1610
Jahreis G, Vogelsang H, Kiessling G, Schubert R, Bunte C, Hammes WP (2002) Influence of probiotic sausage (Lactobacillus paracasei) on blood lipids and immunological parameters of healthy volunteers. Food Res Int 35:133–138
Johansson ML, Nobaek S, Berggren A, Nyman M, Bjorck I, Ahrne S, Jeppsson B, Molin G (1998) Survival of Lactobacillus plantarum DSM 9843 (299v), and effect on the short-chain fatty acid content of faeces after ingestion of a rose-hip drink with fermented oats. Int J Food Microbiol 42:29–38
Kaila M, Isolauri E, Soppi E, Virtanen E, Laine S, Arvilommi H (1992) Enhancement of the circulating antibody secreting cell response in human diarrhoea by a human Lactobacillus strain. Pediatr Res 32:141–144
Kaila M, Isolauri E, Saxelin M, Arvilommi H, Vesikari T (1995) Viable versus inactivated lactobacillus strain GG in acute rotavirus diarrhoea. Arch Dis Child 72:51–53
Kajander K, Krogius-Kurikka L, Rintillä T, Karjalainen H, Palva A, Korpela R (2007) Effects of multispecies probiotic supplementation on intestinal microbiota in irritable bowel syndrome. Aliment Pharmacol Ther 26:463–473
Kajander K, Myllyluoma E, Rajilic-Stojanovic M, Kyronpalo S, Rasmussen M, Jarvenpaa S, Zoetendal EG, De Vos WM, Vapaatalo H, Korpela R (2008) Clinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiota. Aliment Pharmacol Ther 27:48–57
Kalliomaki M, Salminen S, Arvilommi H, Kero P, Koskinen P, Isolauri E (2001) Probiotics in primary prevention of atopic disease: a randomised placebo-controlled trial. Lancet 357:1076–1079
Kalliomaki M, Salminen S, Poussa T, Arvilommi H, Isolauri E (2003) Probiotics and prevention of atopic disease: 4-year follow-up of a randomised placebo-controlled trial. Lancet 361:1869–1871
Kankainen M, Paulin L, Tynkkynen S, von Ossowski I, Reunanen J, Partanen P, Satokari R, Vesterlund S, Hendrickx APA, Lebeer S, De Keersmaecker SCJ, Vanderleyden J, Hämäläinen T, Laukkanen S, Salovuori N, Ritari J, Alatalo E, Korpela R, Mattila-Sandholm T, Lassig A, Hatakka K, Kinnunen KT, Karjalainen H, Saxelin M, Laakso K, Surakka A, Palva A, Salusjärvi T, Auvinen P, de Vos WM (2009) Comparative genomic analysis of Lactobacillus rhamnosus GG reveals pili containing a human- mucus binding protein. Proc Natl Acad Sci 106:17193–17198
Kato I, Endo-Tanaka K, Yokokura T (1998) Suppressive effects of the oral administration of Lactobacillus casei on type II collagen-induced arthritis in DBA/1 mice. Life Sci 63:635–644
Kecskes G, Belagyi T, Olah A (2003) Early jejunal nutrition with combined pre- and probiotics in acute pancreatitis—prospective, randomized, double-blind investigations. Magy Seb 56:3–8
Kirjavainen PV, Arvola T, Salminen SJ, Isolauri E (2002) Aberrant composition of gut microbiota of allergic infants: a target of bifidobacterial therapy at weaning? Gut 51:51–55
Kishi A, Uno K, Matsubara Y, Okuda C, Kishida T (1996) Effect of the oral administration of Lactobacillus brevis subsp. coagulans on interferon-alpha producing capacity in humans. J Am Coll Nutr 15:408–412
Klein A, Friedrich U, Vogelsang H, Jahreis G (2008) Lactobacillus acidophilus 74-2 and Bifidobacterium animalis subsp. lactis DGCC 420 modulate unspecific cellular immune response in healthy adults. Eur J Clin Nutr 62:584–593
Klijn N, Weerkamp AH, de Vos WM (1995) Genetic marking of Lactococcus lactis shows its survival in the human gastrointestinal tract. Appl Environ Microbiol 61:2771–2774
Kopp MV, Salfeld P (2009) Probiotics and prevention of allergic disease. Curr Opin Clin Nutr Metab Care 12:298–303
Korzenik JR, Podolsky DK (2006) Evolving knowledge and therapy of inflammatory bowel disease. Nat Rev Drug Discov 5:197–209
Kruis W, Schutz E, Fric P, Fixa B, Judmaier G, Stolte M (1997) Double-blind comparison of an oral Escherichia coli preparation and mesalazine in maintaining remission of ulcerative colitis. Aliment Pharmacol Ther 11:853–858
Kruis W, Fric P, Pokrotnieks J, Lukas M, Fixa B, Kascak M, Kamm MA, Weismueller J, Beglinger C, Stolte M, Wolff C, Schulze J (2004) Maintaining remission of ulcerative colitis with the probiotic Escherichia coli Nissle 1917 is as effective as with standard mesalazine. Gut 53:1617–1623
Kukkonen K, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M (2007) Probiotics and prebiotic galacto-oligosaccharides in the prevention of allergic diseases: a randomized, double-blind, placebo-controlled trial. J Allergy Clin Immunol 119:192–198
Kullen MJ, Amann MM, O’Shaughnessy MJ, O’Sullivan DJ, Busta FF, Brady LJ (1997) Differentiation of ingested and endogenous bifidobacteria by DNA fingerprinting demonstrates the survival of an unmodified strain in the gastrointestinal tract of humans. J Nutr 127:89–94
Lammers KM, Helwig U, Swennen E, Rizzello F, Venturi A, Caramelli E, Kamm MA, Brigidi P, Gionchetti P, Campieri M (2002) Effect of probiotic strains on interleukin 8 production by HT29/19A cells. Am J Gastroenterol 97:1182–1186
Larsen CN, Nielsen S, Kaestel P, Brockmann E, Bennedsen M, Christensen HR, Eskesen DC, Jacobsen BL, Michaelsen KF (2006) Dose-response study of probiotic bacteria Bifidobacterium animalis subsp. lactis BB-12 and Lactobacillus paracasei subsp. paracasei CRL-341 in healthy young adults. Eur J Clin Nutr 60:1284–1293
Lay C, Rigottier-Gois L, Holmstrom K, Rajilic M, Vaughan EE, de Vos WM, Collins MD, Thiel R, Namsolleck P, Blaut M, Dore J (2005) Colonic microbiota signatures across five northern European countries. Appl Environ Microbiol 71:4153–4155
Lebeer S, Vanderleyden J, De Keersmaecker SCJ (2008) Genes and molecules of Lactobacilli supporting probiotic action. Microbiol Mol Biol Rev 72:728–764
Lindwall S, Fonden R (1984) Passage and survival of L. acidophilus in the human gastrointestinal tract. Int Dairy Fed Bull 21:179
Link-Amster H, Rochat F, Saudan KY, Mignot O, Aeschlimann JM (1994) Modulation of a specific humoral immune response and changes in intestinal flora mediated through fermented milk intake. FEMS Immunol Med Microbiol 10:55–63
Lombardo L, Vernetto A, Blanco I (2009) Clinical evaluation of Lactobacillus paracasei subsp. paracasei F19 with gluco-oligosaccharides in the short-term treatment of irritable bowel syndrome. Microbial Ecol Health Dis 21:28–32
Lund B, Adamsson I, Edlund C (2002) Gastrointestinal transit survival of an Enterococcus faecium probiotic strain administered with or without vancomycin. Int J Food Microbiol 77:109–115
Maassen CB, van Holten JC, Balk F, Heijne den Bak-Glashouwer MJ, Leer R, Laman JD, Boersma WJ, Claassen E (1998) Orally administered Lactobacillus strains differentially affect the direction and efficacy of the immune response. Vet Q 20:S81–S83
Maassen CBM, van Holten-Neelen C, Balk F, den Bak-Glashouwer JH, Leer RJ, Laman JD, Boersma WJA, Claassen E (2000) Strain-dependent induction of cytokine profiles in the gut by orally administered Lactobacillus strains. Vaccine 18:2613–2623
Madden JAJ, Hunter JO (2002) A review of the role of the gut microflora in irritable bowel syndrome and the effects of probiotics. Br J Nutr 88:S67–S72
Madsen K (2008) Probiotics in critically ill patients. J Clin Gastroenterol 42:S116–S118
Madsen KL, Doyle JS, Jewell LD, Tavernini MM, Fedorak RN (1999) Lactobacillus species prevents colitis in interleukin 10 gene-deficient mice. Gastroenterol 116:1107–1114
Majamaa H, Isolauri E (1997) Probiotics: a novel approach in the management of food allergy. J Allergy Clin Immunol 99:179–185
Majamaa H, Isolauri E, Saxelin M, Vesikari T (1995) Lactic acid bacteria in the treatment of acute rotavirus gastroenteritis. J Pediatr Gastroenterol Nutr 20:333–338
Malinen E, Rinttila T, Kajander K, Matto J, Kassinen A, Krogius L, Saarela M, Korpela R, Palva A (2005) Analysis of the faecal microbiota of irritable bowel syndrome patients and healthy controls with real-time PCR. Am J Gastroenterol 100:373–382
Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R, Jarrin C, Chardon P, Marteau P, Roca J, Dore J (2006) Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach. Gut 55:205–211
Marteau P, Pochart P, Bouhnik Y, Zidi S, Goderel I, Rambaud JC (1992) Survival of Lactobacillus acidophilus and Bifidobacterium sp. in the small intestine following ingestion in fermented milk. A rational basis for the use of probiotics in man. Gastroenterol Clin Biol 16:25–28
Marteau P, Pochart P, Bouhnik Y, Rambaud JC (1993) The fate and effects of transiting, nonpathogenic microorganisms in the human intestine. World Rev Nutr Diet 74:1–21
Marzotto M, Maffeis C, Paternoster T, Ferrario R, Rizzotti L, Pellegrino M, Dellaglio F, Torriani S (2006) Lactobacillus paracasei A survives gastrointestinal passage and affects the faecal microbiota of healthy infants. Res Microbiol 157:857–866
Matto J, Maunuksela L, Kajander K, Palva A, Korpela R, Kassinen A, Saarela M (2005) Composition and temporal stability of gastrointestinal microbiota in irritable bowel syndrome–a longitudinal study in IBS and control subjects. FEMS Immunol Med Microbiol 43:213–222
Matto J, Fonden R, Tolvanen T, von Wright A, Vilpponen-Salmela T, Satokari R, Saarela M (2006) Intestinal survival and persistence of probiotic Lactobacillus and Bifidobacterium strains administered in triple-strain yoghurt. Int Dairy J 16:1174–1180
McCarthy J, O’Mahony L, O’Callaghan L, Sheil B, Vaughan EE, Fitzsimons N, Fitzgibbon J, O’Sullivan GC, Kiely B, Collins JK, Shanahan F (2003) Double blind, placebo controlled trial of two probiotic strains in interleukin 10 knockout mice and mechanistic link with cytokine balance. Gut 52:975–980
Meyer AL, Micksche M, Herbacek I, Elmadfa I (2006) Daily intake of probiotic as well as conventional yogurt has a stimulating effect on cellular immunity in young healthy women. Ann Nutr Metab 50:282–289
Miettinen M, Matikainen S, Vuopio-Varkila J, Pirhonen J, Varkila K, Kurimoto M, Julkunen I (1998) Lactobacilli and streptococci induce interleukin-12 (IL-12), IL-18, and gamma interferon production in human peripheral blood mononuclear cells. Infect Immun 66:6058–6062
Mimura T, Rizzello F, Helwig U, Poggioli G, Schreiber S, Talbot IC, Nicholls RJ, Gionchetti P, Campieri M, Kamm MA (2004) Once daily high dose probiotic therapy (VSL#3) for maintaining remission in recurrent or refractory pouchitis. Gut 53:108–114
Misra S, Sabui TK, Pal NK (2009) A randomized controlled trial to evaluate the efficacy of Lactobacillus GG in infantile diarrhoea. J Pediatr 155:129–132
Mohamadzadeh M, Olson S, Kalina WV, Ruthel G, Demmin GL, Warfield KL, Bavari S, Klaenhammer TR (2005) Lactobacilli activate human dendritic cells that skew T cells toward T helper 1 polarization. Proc Natl Acad Sci 102:2880–2885
Morelli L, Zonenschain D, Callegari M, Grossi E, Maisano F, Fusillo M (2003) Assessment of a new synbiotic preparation in healthy volunteers: survival, persistence of probiotic strains and its effect on the indigenous flora. Nutri J 2:11
Muscettola M, Massai L, Tanganelli C, Grasso G (1994) Effects of lactobacilli on interferon production in young and aged mice. Ann N Y Acad Sci 717:226–232
Nobaek S, Johansson M-L, Molin G, Ahrne S, Jeppsson B (2000) Alteration of intestinal microflora is associated with reduction in abdominal bloating and pain in patients with irritable bowel syndrome. Am J Gastroenterol 95:1231–1238
O’Mahony L, Feeney M, O’Halloran S, Murphy L, Kiely B, Fitzgibbon J, Lee G, O’Sullivan G, Shanahan F, Collins JK (2001) Probiotic impact on microbial flora, inflammation and tumour development in IL-10 knockout mice. Aliment Pharmacol Ther 15:1219–1225
Ogawa T, Asai Y, Tamai R, Makimura Y, Sakamoto H, Hashikawa S, Yasuda K (2006) Natural killer cell activities of synbiotic Lactobacillus casei ssp. casei in conjunction with dextran. Clin Exp Immunol 143:103–109
Olivares M, Diaz-Ropero MP, Sierra S, Lara-Villoslada F, Fonolla J, Navas M, Rodriguez JM, Xaus J (2007) Oral intake of Lactobacillus fermentum CECT5716 enhances the effects of influenza vaccination. Nutrition 23:254–260
Oozeer R, Leplingard A, Mater DDG, Mogenet A, Michelin R, Seksek I, Marteau P, Dore J, Bresson J-L, Corthier G (2006) Survival of Lactobacillus casei in the human digestive tract after consumption of fermented Milk. Appl Environ Microbiol 72:5615–5617
Otte JM, Podolsky DK (2004) Functional modulation of enterocytes by gram-positive and gram-negative microorganisms. Am J Physiol Gastrointest Liver Physiol 286:G613–G626
Ouwehand AC, Kurvinen T, Rissanen P (2004) Use of a probiotic Bifidobacterium in a dry food matrix, an in vivo study. Int J Food Microbiol 95:103–106
Park JH, Um JI, Lee BJ, Goh JS, Park SY, Kim WS, Kim PH (2002) Encapsulated Bifidobacterium bifidum potentiates intestinal IgA production. Cell Immunol 219:22–27
Pedrosa MC, Golner BB, Goldin BR, Barakat S, Dallal GE, Russell RM (1995) Survival of yogurt-containing organisms and Lactobacillus gasseri (ADH) and their effect on bacterial enzyme activity in the gastrointestinal tract of healthy and hypochlorhydric elderly subjects. Am J Clin Nutr 61:353–359
Pelto L, Isolauri E, Lilius EM, Nuutila J, Salminen S (1998) Probiotic bacteria down-regulate the milk-induced inflammatory response in milk-hypersensitive subjects but have an immunostimulatory effect in healthy subjects. Clin Exp Allergy 28:1474–1479
Pena JA, Rogers AB, Ge Z, Ng V, Li SY, Fox JG, Versalovic J (2005) Probiotic Lactobacillus spp. diminish Helicobacter hepaticus-induced inflammatory bowel disease in interleukin-10-deficient mice. Infect Immun 73:912–920
Perdigon G, Maldonado Galdeano C, Valdez JC, Medici M (2002) Interaction of lactic acid bacteria with the gut immune system. Eur J Clin Nutr 56:S21–S26
Pessi T, Sutas Y, Saxelin M, Kallioinen H, Isolauri E (1999) Antiproliferative effects of homogenates derived from five strains of candidate probiotic bacteria. Appl Environ Microbiol 65:4725–4478
Plant L, Lam C, Conway PL, O’Riordan K (2003) Gastrointestinal microbial community shifts observed following oral administration of a Lactobacillus fermentum strain to mice. FEMS Microbiol Ecol 43:133–140
Pochard P, Gosset P, Grangette C, Andre C, Tonnel AB, Pestel J, Mercenier A (2002) Lactic acid bacteria inhibit T(H)2 cytokine production by mononuclear cells from allergic patients. J Allergy Clin Immunol 110:617–623
Pochart P, Dewit O, Desjeux JF, Bourlioux P (1989) Viable starter culture, beta-galactosidase activity, and lactose in duodenum after yogurt ingestion in lactase-deficient humans. Am J Clin Nutr 49:828–831
Pochart P, Marteau P, Bouhnik Y, Goderel I, Bourlioux P, Rambaud JC (1992) Survival of bifidobacteria ingested via fermented milk during their passage through the human small intestine: an in vivo study using intestinal perfusion. Am J Clin Nutr 55:78–80
Pohjavuori E, Viljanen M, Korpela R, Kuitunen M, Tiittanen M, Vaarala O, Savilahti E (2004) Lactobacillus GG effect in increasing IFN-gamma production in infants with cow’s milk allergy. J Allergy Clin Immunol 114:131–136
Prantera C, Scribano ML, Falasco G, Andreoli A, Luzi C (2002) Ineffectiveness of probiotics in preventing recurrence after curative resection for Crohn’s disease: a randomised controlled trial with Lactobacillus GG. Gut 51:405–409
Prescott SL, Dunstan JA, Hale J, Breckler L, Lehmann H, Weston S, Richmond P (2005) Clinical effects of probiotics are associated with increased interferon-gamma responses in very young children with atopic dermatitis. Clin Exp Allergy 35:1557–1564
Pronio A, Montesani C, Butteroni C, Vecchione S, Mumolo G, Vestri A, Vitolo D, Boirivant M (2008) Probiotic administration in patients with ileal pouch-anal anastomosis for ulcerative colitis is associated with expansion of mucosal regulatory cells. Inflamm Bowel Dis 14:662–668
Rachmilewitz D, Katakura K, Karmeli F, Hayashi T, Reinus C, Rudensky B, Akira S, Takeda K, Lee J, Takabayashi K, Raz E (2004) Toll-like receptor 9 signaling mediates the anti-inflammatory effects of probiotics in murine experimental colitis. Gastroenterology 126:520–528
Rastall RA (2004) Bacteria in the gut: friends and foes and how to alter the balance. J Nutr 134:2022S–2026S
Rautava S, Arvilommi H, Isolauri E (2006) Specific probiotics in enhancing maturation of IgA responses in formula-fed infants. Ped Res 60:221–224
Rembacken BJ, Snelling AM, Hawkey PM, Chalmers DM, Axon AT (1999) Non-pathogenic Escherichia coli versus mesalazine for the treatment of ulcerative colitis: a randomised trial. Lancet 354:635–639
Rigby RJ, Knight SC, Kamm MA, Stagg AJ (2005) Production of interleukin (IL)-10 and IL-12 by murine colonic dendritic cells in response to microbial stimuli. Clin Exp Immunol 139:245–256
Rinne M, Kalhomaki M, Salminen S, Isolauri E (2006) Probiotic intervention in the first months of life: short-term effects on gastrointestinal symptoms and long-term effects on gut microbiota. J Pediatr Gastroenterol Nutr 43:200–205
Rochet V, Rigottier-Gois L, Sutren M, Krementscki MN, Andrieux C, Furet JP, Tailliez P, Levenez F, Mogenet A, Bresson JL, Meance S, Cayuela C, Leplingard A, Dore J (2006) Effects of orally administered Lactobacillus casei DN-114 001 on the composition or activities of the dominant faecal microbiota in healthy humans. Br J Nutr 95:421–429
Rochet V, Rigottier-Gois L, Levenez F, Cadiou J, Marteau P, Bresson JL, Goupil-Feillerat N, Dore J (2008) Modulation of Lactobacillus casei in ileal and faecal samples from healthy volunteers after consumption of a fermented milk containing Lactobacillus casei DN-114 001(Rif). Can J Microbiol 54:660–667
Roessler A, Friedrich U, Vogelsang H, Bauer A, Kaatz M, Hipler UC, Schmidt I, Jahreis G (2008) The immune system in healthy adults and patients with atopic dermatitis seems to be affected differently by a probiotic intervention. Clin Exp Allergy 38:93–102
Rohde CL, Bartolini V, Jones N (2009) The use of probiotics in the prevention and treatment of antibiotic-associated diarrhoea with special interest in Clostridium difficile-associated diarrhoea. Nutr Clin Pract 24:33–40
Ruiz PA, Hoffmann M, Szcesny S, Blaut M, Haller D (2005) Innate mechanisms for Bifidobacterium lactis to activate transient pro-inflammatory host responses in intestinal epithelial cells after the colonization of germ-free rats. Immunology 115:441–450
Saavedra JM (2007) Use of probiotics in pediatrics: rationale, mechanisms of action, and practicall aspects. Nutr Clin Pract 22:351–365
Saito Y, Sakamoto M, Takizawa S, Benno Y (2004) Monitoring the cell number and viability of Lactobacillus helveticus GCL1001 in human faeces by PCR methods. FEMS Microbiol Lett 231:125–130
Salminen S, Isolauri E (2006) Intestinal colonization, microbiota, and probiotics. J Pediatr 149:S115–S120
Saxelin M, Pessi T, Salminen S (1995) Faecal recovery following oral administration of Lactobacillus strain GG (ATCC 53103) in gelatine capsules to healthy volunteers. Int J Food Microbiol 25:199–203
Schiffrin EJ, Rochat F, Link-Amster H, Aeschlimann JM, Donnet-Hughes A (1995) Immunomodulation of human blood cells following the ingestion of lactic acid bacteria. J Dairy Sci 78:491–497
Schiffrin EJ, Brassart D, Servin AL, Rochat F, Donnet-Hughes A (1997) Immune modulation of blood leukocytes in humans by lactic acid bacteria: criteria for strain selection. Am J Clin Nutr 66:515S–520S
Schultz M, Timmer A, Herfarth HH, Sartor RB, Vanderhoof JA, Rath HC (2004) Lactobacillus GG in inducing and maintaining remission of Crohn’s disease. BMC Gastroenterol 4:5
Sen S, Mullan MM, Parker TJ, Woolner JT, Tarry SA, Hunter JO (2002) Effect of Lactobacillus plantarum 299v on colonic fermentation and symptoms of irritable bowel syndrome. Dig Dis Sci 47:2615–2620
Servin AL (2004) Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiol Rev 28:405–440
Sghir A, Gramet G, Suau A, Rochet V, Pochart P, Dore J (2000) Quantification of bacterial groups within human faecal flora by oligonucleotide probe hybridization. Appl Environ Microbiol 66:2263–2266
Sheih YH, Chiang BL, Wang LH, Liao CK, Gill HS (2001) Systemic immunity-enhancing effects in healthy subjects following dietary consumption of the lactic acid bacterium Lactobacillus rhamnosus HN001. J Am Coll Nutr 20:149–156
Sheil B, McCarthy J, O’Mahony L, Bennett MW, Ryan P, Fitzgibbon JJ, Kiely B, Collins JK, Shanahan F (2004) Is the mucosal route of administration essential for probiotic function? Subcutaneous administration is associated with attenuation of murine colitis and arthritis. Gut 53:694–700
Shida K, Takahashi R, Iwadate E, Takamizawa K, Yasui H, Sato T, Habu S, Hachimura S, Kaminogawa S (2002) Lactobacillus casei strain Shirota suppresses serum immunoglobulin E and immunoglobulin G1 responses and systemic anaphylaxis in a food allergy model. Clin Exp Allergy 32:563–570
Shida K, Kiyoshima-Shibata J, Nagaoka M, Watanabe K, Nanno M (2006) Induction of interleukin-12 by lactobacillus strains having a rigid cell wall resistant to intracellular digestion. J Dairy Sci 89:3306–3317
Shinoda T, Kusuda D, Ishida Y, Ikeda N, Kaneko K, Masuda O, Yamamoto N (2001) Survival of Lactobacillus helveticus strain CP53 in the human gastrointestinal tract. Lett Appl Microbiol 32:108–113
Smits HH, Engering A, van der Kleij D, de Jong EC, Schipper K, van Capel TM, Zaat BA, Yazdanbakhsh M, Wierenga EA, van Kooyk Y, Kapsenberg ML (2005) Selective probiotic bacteria induce IL-10-producing regulatory T cells in vitro by modulating dendritic cell function through dendritic cell-specific intercellular adhesion molecule 3-grabbing nonintegrin. J Allergy Clin Immunol 115:1260–1267
Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottiere HM, Dore J, Marteau P, Seksik P, Langella P (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci 105:16731–16736
Sokol H, Seksik P, Furet JP, Firmesse O, Nion-Larmurier L, Beaugerie L, Cosnes J, Corthier G, Marteau P, Dore J (2009) Low counts of Faecalibacterium prausnitzii in colitis microbiota. Inflamm Bowel Dis 15:1183–1189
Spanhaak S, Havenaar R, Schaafsma G (1998) The effect of consumption of milk fermented by Lactobacillus casei strain Shirota on the intestinal microflora and immune parameters in humans. Eur J Clin Nutr 52:899–907
Strober W, Fuss IJ, Blumberg RS (2002) The immunology of mucosal models of inflammation. Ann Rev Immunol 20:495–549
Sturm A, Rilling K, Baumgart DC, Gargas K, Abou-Ghazale T, Raupach B, Eckert J, Schumann RR, Enders C, Sonnenborn U, Wiedenmann B, Dignass AU (2005) Escherichia coli Nissle 1917 distinctively modulates T-cell cycling and expansion via toll-like receptor 2 signaling. Infect Immun 73:1452–1465
Su P, Henriksson A, Tandianus JE, Park JH, Foong F, Dunn NW (2005) Detection and quantification of Bifidobacterium lactis LAFTI B94 in human faecal samples from a consumption trial. FEMS Microbiol Lett 244:99–103
Suau A, Rochet V, Sghir A, Gramet G, Brewaeys S, Sutren M, Rigottier-Gois L, Dore J (2001) Fusobacterium prausnitzii and related species represent a dominant group within the human faecal flora. Syst Appl Microbiol 24:139–145
Sullivan A, Barkholt L, Nord CE (2003) Lactobacillus acidophilus, Bifidobacterium lactis and Lactobacillus F19 prevent antibiotic-associated ecological disturbances of Bacteroides fragilis in the intestine. J Antimicrob Chemother 52:308–311
Tanaka S, Kobayashi T, Songjinda P, Tateyama A, Tsubouchi M, Kiyohara C, Shirakawa T, Sonomoto K, Nakayama J (2009) Influence of antibiotic exposure in the early postnatal period on the development of intestinal microbiota. FEMS Immunol Med Microbiol 56:80–87
Tannock GW (2003) Probiotics: time for a dose of realism. Curr Issues Intest Microbiol 4:33–42
Tannock GW, Munro K, Harmsen HJM, Welling GW, Smart J, Gopal PK (2000) Analysis of the faecal microflora of human subjects consuming a probiotic product containing Lactobacillus rhamnosus DR20. Appl Environ Microbiol 66:2578–2588
Tap J, Mondot S, Levenez F, Pelletier E, Caron C, Furet JP, Ugarte E, Munoz-Tamayo R, Paslier DLE, Nalin R, Dore J, Leclerc M (2009) Towards the human intestinal microbiota phylogenetic core. Environ Microbiol 11:2574–2584
Taylor AL, Dunstan JA, Prescott SL (2007) Probiotic supplementation for the first 6 months of life fails to reduce the risk of atopic dermatitis and increases the risk of allergen sensitization in high-risk children: a randomized controlled trial. J Allergy Clin Immunol 119:184–191
Tien MT, Girardin SE, Regnault B, Le Bourhis L, Dillies MA, Coppee JY, Bourdet-Sicard R, Sansonetti PJ, Pedron T (2006) Anti-inflammatory effect of Lactobacillus casei on Shigella-infected human intestinal epithelial cells. J Immunol 176:1228–1237
Tlaskalová-Hogenová H, Stepánková R, Hudcovic T, Tucková L, Cukrowska B, Lodinová-Zádníková R, Kozáková H, Rossmann P, Bártová J, Sokol D, Funda DP, Borovská D, Reháková Z, Sinkora J, Hofman J, Drastich P, Kokesová A (2004) Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol Lett 93:97–108
Tuohy KM, Pinart-Gilberga M, Jones M, Hoyles L, McCartney AL, Gibson GR (2007) Survivability of a probiotic Lactobacillus casei in the gastrointestinal tract of healthy human volunteers and its impact on the faecal microflora. J Appl Microbiol 102:1026–1032
Vesa T, Pochart P, Marteau P (2000) Pharmacokinetics of Lactobacillus plantarum NCIMB 8826, Lactobacillus fermentum KLD, and Lactococcus lactis MG 1363 in the human gastrointestinal tract. Aliment Pharmacol Ther 14:823–828
Viljanen M, Kuitunen M, Haahtela T, Juntunen-Backman K, Korpela R, Savilahti E (2005a) Probiotic effects on faecal inflammatory markers and on faecal IgA in food allergic atopic eczema/dermatitis syndrome infants. Pediatr Allergy Immunol 16:65–71
Viljanen M, Pohjavuori E, Haahtela T, Korpela R, Kuitunen M, Sarnesto A, Vaarala O, Savilahti E (2005b) Induction of inflammation as a possible mechanism of probiotic effect in atopic eczema-dermatitis syndrome. J Allergy Clin Immunol 115:1254–1259
Viljanen M, Savilahti E, Haahtela T, Juntunen-Backman K, Korpela R, Poussa T, Tuure T, Kuitunen M (2005c) Probiotics in the treatment of atopic eczema/dermatitis syndrome in infants: a double-blind placebo-controlled trial. Allergy 60:494–500
Vinderola G, Matar C, Perdigon G (2005) Role of intestinal epithelial cells in immune effects mediated by gram-positive probiotic bacteria: involvement of toll-like receptors. Clin Diagn Lab Immunol 12:1075–1084
von der Weid T, Bulliard C, Schiffrin EJ (2001) Induction by a lactic acid bacterium of a population of CD4+ T cells with low proliferative capacity that produce transforming growth factor β and Interleukin-10. Clin Diagn Lab Immunol 8:695–701
Xiao SD, Zhang de Z, Lu H, Jiang SH, Liu HY, Wang GS, Xu GM, Zhang ZB, Lin GJ, Wang GL (2003) Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhoea. Adv Ther 20:253–260
Yamano T, Iino H, Takada M, Blum S, Rochat F, Fukushima Y (2006) Improvement of the human intestinal flora by ingestion of the probiotic strain Lactobacillus johnsonii La1. Br J Nutr 95:303–312
Yuki N, Watanabe K, Mike A, Tagami Y, Tanaka R, Ohwaki M, Morotomi M (1999) Survival of a probiotic, Lactobacillus casei strain Shirota, in the gastrointestinal tract: selective isolation from faeces and identification using monoclonal antibodies. Int J Food Microbiol 48:51–57
Zanello G, Meurens F, Berri M, Salmon H (2009) Saccharomyces boulardii effects on gastrointestinal diseases. Curr Issues Mol Biol 11:47–58
Zhang L, Li N, Caicedo R, Neu J (2005) Alive and dead Lactobacillus rhamnosus GG decrease tumor necrosis factor-alpha-induced interleukin-8 production in Caco-2 cells. J Nutr 135:1752–1756
Zoetendal EG, Akkermans ADL, De Vos WM (1998) Temperature gradient gel electrophoresis analysis of 16S rRNA from human faecal samples reveals stable and host-specific communities of active bacteria. Appl Environ Microbiol 64:3854–3859
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Roy, D., Delcenserie, V. (2011). The Protective Role of Probiotics in Disturbed Enteric Microbiota. In: Malago, J., Koninkx, J., Marinsek-Logar, R. (eds) Probiotic Bacteria and Enteric Infections. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0386-5_11
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