Abstract
Gangliogliomas are mixed glioneuronal tumors with two histological features: atypical ganglion cells and neoplastic glial cells. They comprise approximately 0.4% of all central nervous system tumors and less than 2% of all intracranial tumors. Gangliogliomas are usually located in temporal lobe. Brainstem gangliogliomas are unusual tumors and only few cases have been reported in the literature. Complete tumor resection if feasible, is usually associated with good prognosis. The surgical management of these tumors depends on their location. The definitive role of radiotherapy and chemotherapy has not yet been established. Even after resection a close long-term follow-up is mandatory for these patients.
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References
Alexiou GA, Varela M, Sfakianos G, Prodromou N (2009) Benign lesions accompanied by intractable epilepsy in children. J Child Neurol 24:697–700
Cultrera F, Guiducci G, Nasi MT, Paioli G, Frattarelli M (2006) Two-stage treatment of a tectal ganglioglioma: endoscopic third ventriculostomy followed by surgical resection. J Clin Neurosci 13:963–965
Epstein FJ, Farmer JP (1993) Brain-stem glioma growth patterns. J Neurosurg 78:408–412
Hirose T, Kannuki S, Nishida K, Matsumoto K, Sano T, Hizawa K (1992) Anaplastic ganglioglioma of the brain stem demonstrating active neurosecretory features of neoplastic neuronal cells. Acta Neuropathol 83:365–370
Hukin J, Siffert J, Velasquez L, Zagzag D, Allen J (2002) Leptomeningeal dissemination in children with progressive low-grade neuroepithelial tumors. Neurooncol 4:253–260
Im SH, Chung CK, Cho BK, Wang KC, Yu IK, Song IC, Cheon GJ, Lee DS, Kim NR, Chi JG (2002) Intracranial ganglioglioma: preoperative characteristics and oncologic outcome after surgery. J Neurooncol 59:173–183
Jallo GI, Biser-Rohrbaugh A, Freed D (2004) Brainstem gliomas. Childs Nerv Syst 20:143–153
Jallo GI, Freed D, Roonprapunt C, Epstein F (2003) Current management of brainstem gliomas. Ann Neurosurg 3:1–17
Karremann M, Pietsch T, Janssen G, Kramm CM, Wolff JE (2009) Anaplastic ganglioglioma in children. J Neurooncol 92:157–163
Lagares A, Gómez PA, Lobato RD, Ricoy JR, Ramos A, de la Lama A (2001) Ganglioglioma of the brainstem: report of three cases and review of the literature. Surg Neurol 56:315–322
Lang FF, Epstein FJ, Ransohoff J, Allen JC, Wisoff J, Abbott R, Miller DC (1993) Central nervous system gangliogliomas part 2: clinical outcome. J Neurosurg 79:867–873
Law M, Meltzer DE, Wetzel SG, Yang S, Knopp EA, Golfinos J, Johnson G (2004) Conventional MR imaging with simultaneous measurements of cerebral blood volume and vascular permeability in ganglioglioma. Magn Reson Imaging 22:599–606
Liauw SL, Byer JE, Yachnis AT, Amdur RJ, Mendenhall WM (2007) Radiotherapy after subtotally resected or recurrent ganglioglioma. Int J Radiat Oncol Biol Phys 67:244–247
Luyken C, Blumcke I, Fimmers R, Urbach H, Wiestler OD, Schramm J (2004) Supratentorial gangliogliomas: histopatholic grading and tumor recurrence in 184 patients with a median follow-up of 8 years. Cancer 101:146–155
Milligan BD, Giannini C, Link MJ (2007) Ganglioglioma in the cerebellopontine angle in a child. Case report and review of the literature. J Neurosurg 107:292–296
Morota N, Ihara S, Deletis V (2010) Intraoperative neurophysiology for surgery in and around the brainstem: role of brainstem mapping and corticobulbar tract motor-evoked potential monitoring. Childs Nerv Syst 26:513–521
Mpairamidis E, Alexiou GA, Stefanaki K, Sfakianos G, Prodromou N (2008) Brainstem ganglioglioma. J Child Neurol 23:1481–1483
Mussi AC, Rhoton AL Jr. (2000) Telovelar approach to the fourth ventricle: microsurgical anatomy. J Neurosurg 92:812–823
Rades D, Zwick L, Leppert J, Bonsanto MM, Tronnier V, Dunst J, Schild SE (2010) The role of postoperative radiotherapy for the treatment of gangliogliomas. Cancer 116:432–442
Rumana CS, Valadka AB (1998) Radiation therapy and malignant degeneration of benign supra-tentorial gangliogliomas. Neurosurgery 42:1038–1043
Sala F, Manganotti P, Tramontano V, Bricolo A, Gerosa M (2007) Monitoring of motor pathways during brain stem surgery: what we have achieved and what we still miss?. Neurophysiol Clin 37:399–406
Sharma MS, Kondziolka D, Khan A, Kano H, Niranjan A, Flickinger JC, Lunsford LD (2008) Radiation tolerance limits of the brainstem. Neurosurgery 63:728–732
Zentner J, Wolf HK, Ostertun B, Hufnagel A, Campos MG, Solymosi L, Schramm J (1994) Gangliogliomas: clinical, radiological, and histopathological findings in 51 patients. J Neurol Neurosurg Psychiatry 57:1497–1502
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Alexiou, G.A., Prodromou, N. (2011). Brainstem Gangliogliomas: Total Resection and Close Follow-Up. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 1. Tumors of the Central Nervous System, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0344-5_24
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DOI: https://doi.org/10.1007/978-94-007-0344-5_24
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