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Glioblastomas: Role of CXCL12 Chemokine

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Tumors of the Central Nervous System, Volume 1

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 1))

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Abstract

Chemokines are small pro-inflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors on the plasma membrane of target cells. They are also the major regulators of cell trafficking. Chemokines and their receptors were initially associated with the trafficking of leukocytes during physiological immune surveillance and with inflammatory cell recruitment in different diseases. CXCL 12, an alpha-chemokine that binds to G-protein-coupled CXCR4, plays an important and unique role in the regulation of stem/progenitor cell trafficking. Since CXCR4 is expressed on several tumor cells, these CXCR4-positive tumor cells may metastasize to organs that secrete/express CXCL12. In the specific case of gliomas, recent data show that CXCR4 and CXCL12 mRNAs colocalize to glioblastomas and that their expression increases with tumor grade and is associated with regions of necrosis and angiogenesis. This chapter summarises our current knowledge regarding the role of the CXCL12/CXCR4 axis in the central nervous system, focusing on the molecular mechanism by which the CXCL12/CXCR4 axis functions in the accelerated growth of glioblastomas, and further introduces the potential role of CXCL12/CXCR4-targeting compounds for the treatment of glioblastomas.

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Authors and Affiliations

  1. Department of Pathology, Kurume University School of Medicine, Kurume, Fukuoka, 830-0011, Japan

    Yasuo Sugita

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  1. Yasuo Sugita
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Correspondence to Yasuo Sugita .

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Editors and Affiliations

  1. Dept. Biological Sciences, Kean University, 1000 Moris Avenue, Union, 07083, New Jersey, USA

    M. A. Hayat

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Sugita, Y. (2011). Glioblastomas: Role of CXCL12 Chemokine. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 1. Tumors of the Central Nervous System, vol 1. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0344-5_15

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  • DOI: https://doi.org/10.1007/978-94-007-0344-5_15

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-0343-8

  • Online ISBN: 978-94-007-0344-5

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