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MicroRNAs in Epithelial Ovarian Cancer

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MicroRNAs in Cancer Translational Research

Abstract

Epithelial ovarian cancer is one of the most common gynecological cancers worldwide. Despite decades of researches, it remains a major cause of morbidity and mortality among women in the United States. However, progress has been made on understanding the cellular and molecular mechanisms for ovarian cancer. Frequent mutations in the p53/Rb tumor suppressor pathways and activation of oncogenic signaling pathways such as c-Myc, K-ras, and Akt greatly contribute to disease progression. Recently, microRNAs (miRNAs) have been demonstrated to be a novel class of regulators in cell proliferation, differentiation, and apoptosis. Functional studies revealed that miRNAs play an important role during tumorigenesis, cancer progression, and therapeutic response. Gene expression profiling studies found aberrant miRNA expressions in essentially all types of tumors studied. In this chapter, we will review recent researches on the role of miRNAs in ovarian cancer and discuss how these studies can improve our understanding of ovarian cancer pathogenesis. We also discuss the perspectives of miRNAs as diagnostic and prognostic tools in clinical practice, and as new avenues for therapeutic development.

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Acknowledgments

This work was partly supported by grants from the Breast Cancer Alliance, the Ovarian Cancer Research Found, the Mary Kay Ash Charitable Foundation, National Cancer Institute (R01CA142776 and Ovarian Cancer SPORE P50CA83638-7951), and US Department of Defense (W81XWH-10-1-0082).

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Authors and Affiliations

  1. Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Chunsheng Li

  2. Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, PA, 19104, USA

    Yi Feng

  3. Department of Obstetrics and Gynecology, Abramson Family Cancer Research Institute, Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania, Philadelphia, PA, 19104, USA

    George Coukos

  4. Department of Obstetrics and Gynecology, Center for Research on Early Detection and Cure of Ovarian Cancer, University of Pennsylvania School of Medicine, Philadelphia, PA, 19104, USA

    Lin Zhang

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  1. Chunsheng Li
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  2. Yi Feng
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  4. Lin Zhang
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Correspondence to Lin Zhang .

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  1. , Department of Clinical Oncology, Queen Elizabeth Hospital, Gascoigne Road 30, Hong Kong SAR, China, People's Republic

    William C.S. Cho

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Li, C., Feng, Y., Coukos, G., Zhang, L. (2011). MicroRNAs in Epithelial Ovarian Cancer. In: Cho, W. (eds) MicroRNAs in Cancer Translational Research. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0298-1_14

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