Modeling the Vestibular Nucleus

  • Alexandru CodreanEmail author
  • Adrian Korodi
  • Toma-Leonida Dragomir
  • Vlad Ceregan
Part of the Lecture Notes in Electrical Engineering book series (LNEE, volume 70)


In recent years the vestibular-sympathetic reflex has received an increasing amount of attention due to the role it could play in the human organism in different types of scenarios. Despite this, quantitative models of this reflex mechanism are still lacking. In this context, the current paper aims at taking a first step towards the modeling of the vestibular-sympathetic reflex by developing a model of the Vestibular Nucleus – the central part of the vestibular-sympathetic reflex. After a careful analysis of the limitations and uncertainties of the available experimental data from the literature, a three step modeling methodology for the Vestibular Nucleus is presented. After a description of the operations involved in each step, in the end, some preliminary results are shown.


Vestibular nucleus Interpolation Firing rate Vestibular-sympathetic reflex 


  1. 1.
    Carter, J.R., Chester, A.R.: Sympathetic responses to vestibular activation in humans. Am. J. Physiol. Integr. Comp. Physiol. 294, R681–R688 (2008) CrossRefGoogle Scholar
  2. 2.
    Radtke, A., Popov, K., Bronstein, A.M., Gresty, M.A.: Vestibulo-autonomic control in man: Short- and long-latency vestibular effects on cardiovascular function. J. Vest. Res. 13(1), 25–37 (2003) Google Scholar
  3. 3.
    Olufsen, M., Ottesen, J., Tran, H., Lipsitz, L., Novak, V.: Modeling baroreflex regulation of heart rate during orthostatic stress. Am. J. Physiol. Reg. Integr. Comp. Physiol. 291, R1355–R1368 (2006) CrossRefGoogle Scholar
  4. 4.
    Young, L.R., Meiry, J.L.: A revised dynamic otolith model. Aerospace Med. 39, 606–608 (1968) Google Scholar
  5. 5.
    Oliver, J., Coenen, M.D.: Modeling the vestibulo-ocular reflex and the cerebellum: analytical & computational approaches. PhD Thesis, University of California, San Diego (1999) Google Scholar
  6. 6.
    Roy, A., Iqbal, K.: Kinematic trajectory generation in a neuromusculoskeletal model with somatosensory and vestibular feedback. In: 6th IFAC Symposium on Modeling and Control in Biomedical Systems, Reins, September 2006 Google Scholar
  7. 7.
    du Lac S., Lisberger, S.G.: Cellular processing of temporal information in medial vestibular nucleus neurons. J. Neurosci., 8000–8010 (1995) Google Scholar
  8. 8.
    Brodal, P.: The Central Nervous System: Structure and Function, 3rd edn. Oxford University Press, London (2004) Google Scholar
  9. 9.
    Raisch, J., Francis, B.A.: Modeling Deterministic Uncertainty. The Control Handbook, CRC Press, Boca Raton (1996) Google Scholar
  10. 10.
    Uno, A., Idoux, E., Beraneck, M., Vidal, P.-P., Moore, L.E., Wilson, V.J., Vibert, N.: Static and dynamic membrane properties of lateral vestibular nucleus neurons in Guinea pig brain stem slices. J. Neurophysiol. 90, 1689–1703 (2003) CrossRefGoogle Scholar
  11. 11.
    Ris, L., Hachemaoui, M., Vibert, N., Godaux, E., Vidal, P.P., Moore, L.E.: Resonance of spike discharge modulation in neurons of the Guinea pig medial vestibular nucleus. J. Neurophysiol. 86, 703–716 (2001) Google Scholar
  12. 12.
    Ramachandran, R., Lisberger, S.G.: Transformation of vestibular signals into motor commands in the vestibuloocular reflex pathways of monkeys. J. Neurophysiol. 96, 1061–1074 (2006) CrossRefGoogle Scholar
  13. 13.
    Codrean, A., Ceregan, V., Dragomir, T.-L., Korodi, A.: Interpolative frequency characteristics generators for the vestibular nucleus activity. In: Lecture Notes in Engineering and Computer Science: Proceedings of the International MultiConference of Engineers and Computer Scientists 2010, IMECS 2010, Hong Kong, 17–19 March 2010, pp. 195–199 (2010) Google Scholar
  14. 14.
    Korodi, A., Ceregan, V., Dragomir, T.-L., Codrean, A.: A continuous-time dynamical model for the vestibular nucleus. In: IFMBE Proceedings, XII Mediterranean Conference on Medical and Biological Engineering and Computing, Chalkidiki, pp. 627–630 (2010) Google Scholar
  15. 15.
    Ceregan, V., Korodi, A., Dragomir, T.-L., Codrean, A.: An interpolative based dynamical model for the vestibular nucleus. In: ICCC-CONTI Proc., Timisoara, pp. 31–36 (2010) Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • Alexandru Codrean
    • 1
    Email author
  • Adrian Korodi
    • 2
  • Toma-Leonida Dragomir
    • 3
  • Vlad Ceregan
    • 4
  1. 1.“Politehnica” University of TimisoaraTimisoaraRomania
  2. 2.“Politehnica” University of TimisoaraTimisoaraRomania
  3. 3.“Politehnica” University of TimisoaraTimisoaraRomania
  4. 4.“Politehnica” University of TimisoaraTimisoaraRomania

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