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TRP Channels in Urinary Bladder Mechanosensation

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Transient Receptor Potential Channels

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

The lower urinary tract has two main functions: storage and periodic elimination of urine [1]. These functions are controlled by complex neural circuits of reflex pathways located in the brain, the spinal cord and the periphery. The lower urinary tract constantly sends mechanosensory information to the central nervous system via afferent pathway. These signals generate sensation and trigger voiding responses. Alterations in afferent activity may lead to lower urinary tract dysfunction. The increase of afferent excitability is one of mechanisms for overactive bladder syndrome and for painful bladder syndrome [1, 2]. However, the precise mechanisms by which mechanical stimuli excite bladder afferents remain unclear.

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  1. Department of Urology, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Yamanashi, 409-3898, Japan

    Isao Araki

  2. Department of Urology, Shiga University of Medical Science, Otsu, Shiga, 520-2192, Japan

    Isao Araki

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  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Araki, I. (2011). TRP Channels in Urinary Bladder Mechanosensation. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_45

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