Abstract
A novel porcine collagen-based paste dermal substitute to treat full-thickness wounds has been investigated. A thin split-thickness skin graft or autologous cultured keratinocytes have been combined with dermal replacement biomaterial and applied to full-thickness wounds in a porcine wound chamber preclinical experimental model. The data obtained suggest that: (1) dermal substitute biomaterials may improve wound re-epithelialisation when combined with cultured autologous keratinocytes and (2) porcine collagen paste is able to support split-thickness skin graft survival as well as autologous cultured keratinocyte proliferation. These results demonstrate that the novel porcine collagen paste has a potential as a dermal substitute to treat acute full-thickness wounds and an application for the burns emergency care treatment.
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Acknowledgments
We would like to thank the Blond McIndoe Research Foundation and the Mark Hanna Fellowship for funding this research; staff at the Blond McIndoe Research Foundation, Northwick Park Institute for Medical Research and the University of Brighton for their support; Ms. C. Gray at NPIMR for technical operative assistance, and Dr P. Sibbons for providing the Permacol® Injectable material used in this study.
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Shevchenko, R.V., Sibbons, P.D., Sharpe, J.R., James, S.E. (2011). A Novel Skin Substitute Biomaterial to Treat Full-Thickness Wounds in a Burns Emergency Care. In: Mikhalovsky, S., Khajibaev, A. (eds) Biodefence. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0217-2_25
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DOI: https://doi.org/10.1007/978-94-007-0217-2_25
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