Abstract
Heavy metals, anthropogenic toxicants, can penetrate into the human organism in tiny amounts through food and water and then accumulate, promoting development of chronic poisonings and the reduction of human adaptability to the environment. Modeling of heavy metal anthropogenic pollution makes it possible to study the mechanism and nature of heavy metals pathological effect on humans and animals. The knowledge of heavy metals cytotoxic properties and mechanisms of their interaction with living species opens new prospects in the search for a prevention and therapeutic treatment of chronic diseases associated with the effect of xenobiotics. In this paper, pathological disorders in liver due to heavy metals effects and their treatment have been investigated.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsReferences
Katznelson BA, Makeev OG, Degtyareva TD et al (2007) Experimental trial of the complex of means of biological protection of human organism from carcinogenic effect of a combination of exotoxins. Toksikologicheskii Vestnik (Russian “Toxicological Reports”) 3:15–20
Lugovskoy SP, Legkostup LA (2002) Mechanism of biological action of lead on digestive system. Sovremennye Problemy Toksikologii (Russian “Modern Problems of Toxicology”) 2:45–50
Skachkov MB, Skachkova MA, Vereshchagin NN, Korneev AG (2002) The mechanism responsible for predisposition to acute respiratory diseases in high man-made loaded areas. Gigiena i Sanitariia (Russian “Hygiene and Sanitary Journal”) 5:39–42
Fowler BA (1992) Mechanisms of kidney cell injury from metals. Environ Health Perspect 100:56–63
Martel J, Marion M, Denizenu F (1990) Effect of cadmium on membrane potential in isolated rat hepatocytes. Toxicology 60:161–172
Giri SN, Hollinger MA (1995) Effect of cadmium on lung lysosomal enzymes in vitro. Arch Toxicol 69(5):341–345
Tsujimoto Y, Shimizu S (2002) The voltage-dependent anion channel: an essential player in apoptosis. Biochemie 84:187–193
Petrov VV, Podosinovikova PP, Kubraskaya LG, Dolgo-Saburov VB (2004) Contribution of the pro-oxidant factor to the mechanism of heavy metals and manganese toxicity. Toksikologicheskii Vestnik (Russian “Toxicological Reports”) 1:12–15
Coban T, Beduke Y, Iscan M (1996) In vitro effect of cadmium and nickel on glutathione, lipid peroxidation and glutathione-S-transferase in human kidneys. Toxicol in Vitro 10:241–245
Gaetke LM, Chow CK (2003) Copper toxicity, oxidative stress and antioxidant nutrients. Toxicology 189:147–163
Irshad M, Chaudhuri PS (2002) Oxidant-antioxidant system: role and significance in human body. Indian J Exp Biol 40(11):1233–1239
Haonzi D, Lekahal M, Morean A et al (2000) Cytochrome P450-generated reactive metabolites cause mitochondrial permeability transition, cuspate activation and apoptosis in rat hepatocytes. Hepatology 32:303–311
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media B.V.
About this paper
Cite this paper
Gutnikova, A.R. et al. (2011). Rehabilitation Methods for Exposure to Heavy Metals Under Environmental Conditions. In: Mikhalovsky, S., Khajibaev, A. (eds) Biodefence. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0217-2_22
Download citation
DOI: https://doi.org/10.1007/978-94-007-0217-2_22
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-0216-5
Online ISBN: 978-94-007-0217-2
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)