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Immobilization and Controlled Release of Bioactive Substances from Stimuli-Responsive Hydrogels

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Biodefence

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Abstract

Drugs and proteins were immobilized within the spatial structure of thermo- and pH sensitive hydrogels. The release of drugs and proteins in response to environmental changes were studied. The temperature of swelling-shrinking behavior change of hydrogels decreased in the following order: NIPA-APSA (35°C)  >  NIPA-AA (34.4°C) > NIPA-AA/Richlocaine (33.8°C)  >  PNIPA (32.7°C). Oscillating “on-off  ” release mechanism of drug and proteins from the PNIPA and NIPA-AA hydrogels were observed in the course of cyclic shrinking and swelling of hydrogels in water and phosphate buffer at 25°C and 40°C.

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Author information

Authors and Affiliations

  1. Institute of Polymer Materials and Technology, Panfilov str. 52/104, Almaty, 050004, Kazakhstan

    S. E. Kudaibergenov, G. S. Tatykhanova & Zh. E. Ibraeva

  2. Laboratory of Engineering Profile, K.I. Satpaev Kazakh National Technical University, Satpaev str. 22, Almaty, 050013, Kazakhstan

    S. E. Kudaibergenov, G. S. Tatykhanova & Zh. E. Ibraeva

Authors
  1. S. E. Kudaibergenov
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  2. G. S. Tatykhanova
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  3. Zh. E. Ibraeva
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Corresponding author

Correspondence to S. E. Kudaibergenov .

Editor information

Editors and Affiliations

  1. School of Pharmacy &, Biomolecular Sciences, University of Brighton, Lewes Road, Brighton, East Sussex, BN2 4GJ, United Kingdom

    Sergey Mikhalovsky

  2. Center for Emergency Medicine, Ministry of Public Health, Republican Specialised Scientific, Tashkent, 100115, Uzbekistan

    Abdukhakim Khajibaev

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Kudaibergenov, S.E., Tatykhanova, G.S., Ibraeva, Z.E. (2011). Immobilization and Controlled Release of Bioactive Substances from Stimuli-Responsive Hydrogels. In: Mikhalovsky, S., Khajibaev, A. (eds) Biodefence. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0217-2_19

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