Microscale Flow Dynamics of Red Blood Cells in Microchannels: An Experimental and Numerical Analysis

  • R. LimaEmail author
  • C. S. Fernandes
  • R. Dias
  • T. Ishikawa
  • Y. Imai
  • T. Yamaguchi
Part of the Computational Methods in Applied Sciences book series (COMPUTMETHODS, volume 19)


The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW ®;, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.


Blood flow Microvascular networks Bifurcation Microchannel 



This study was supported in part by the following grants: Grant-in-Aid for Science and Technology (BII/UNI/0532/EME/2008, PTDC/SAU-BEB/108728/2008, PTDC/SAU-BEB/105650/2008 and PTDC/EME-MFE/099109/2008) from the Science and Technology Foundation (FCT) and COMPETE, Portugal and Grant-in-Aid for Scientific Research (S) from the Japan Society for the Promotion of Science (JSPS; No.19100008). We also acknowledge the support from the 2007 Global COE Program “Global Nano-Biomedical Engineering Education and Research Network”. The authors would like also to thank Dr. C. Balsa for his valuable assistance and support for the MATLAB numerical calculations and Ms. B. Oliveira, Ms. D. Cidre and Mr. M. Lagoela for their valuable technical assistance in this researchwork.


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Copyright information

© Springer Science+Business Media B.V. 2011

Authors and Affiliations

  • R. Lima
    • 1
    • 2
    Email author
  • C. S. Fernandes
    • 1
  • R. Dias
    • 1
    • 2
  • T. Ishikawa
    • 3
  • Y. Imai
    • 3
  • T. Yamaguchi
    • 4
  1. 1.ESTiG, IPBBragancaPortugal
  2. 2.CEFT, FEUPPortoPortugal
  3. 3.Department of Bioengineering & Robotics, Graduate School of EngineeringTohoku UniversitySendaiJapan
  4. 4.Department of Biomedical Engineering, Graduate School of EngineeringTohoku UniversitySendaiJapan

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