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Computational Vision and Medical Image Processing pp 297–309Cite as

Microscale Flow Dynamics of Red Blood Cells in Microchannels: An Experimental and Numerical Analysis

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Part of the book series: Computational Methods in Applied Sciences ((COMPUTMETHODS,volume 19))

Abstract

The blood flow dynamics in microcirculation depends strongly on the microvascular networks composed with short irregular vessel segments which are linked by numerous bifurcations. This paper presents the application of a confocal micro-PTV system to track RBCs through a rectangular polydimethysiloxane (PDMS) microchannel with a bifurcation. By using a confocal micro-PTV system, we have measured the effect of bifurcation on the flow behaviour of both fluorescent particles diluted in pure water and RBCs in concentrated suspensions. After performing simulations with the commercial finite element software package POLYFLOW®;, some experimental results were compared with the numerical results and the limitations of these simulations were outlined.

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Acknowledgements

This study was supported in part by the following grants: Grant-in-Aid for Science and Technology (BII/UNI/0532/EME/2008, PTDC/SAU-BEB/108728/2008, PTDC/SAU-BEB/105650/2008 and PTDC/EME-MFE/099109/2008) from the Science and Technology Foundation (FCT) and COMPETE, Portugal and Grant-in-Aid for Scientific Research (S) from the Japan Society for the Promotion of Science (JSPS; No.19100008). We also acknowledge the support from the 2007 Global COE Program “Global Nano-Biomedical Engineering Education and Research Network”. The authors would like also to thank Dr. C. Balsa for his valuable assistance and support for the MATLAB numerical calculations and Ms. B. Oliveira, Ms. D. Cidre and Mr. M. Lagoela for their valuable technical assistance in this researchwork.

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Authors and Affiliations

  1. ESTiG, IPB, C. Sta. Apolonia, 5301-857, Braganca, Portugal

    R. Lima, C. S. Fernandes & R. Dias

  2. CEFT, FEUP, R. Dr. Roberto Frias, 4200-465, Porto, Portugal

    R. Lima & R. Dias

  3. Department of Bioengineering & Robotics, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579, Sendai, Japan

    T. Ishikawa & Y. Imai

  4. Department of Biomedical Engineering, Graduate School of Engineering, Tohoku University, 6-6-01 Aoba, 980-8579, Sendai, Japan

    T. Yamaguchi

Authors
  1. R. Lima
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  2. C. S. Fernandes
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  3. R. Dias
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  4. T. Ishikawa
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  5. Y. Imai
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  6. T. Yamaguchi
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Correspondence to R. Lima .

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Editors and Affiliations

  1. Fac. Engenharia, Lab. Engenharia de Processos,, Universidade do Porto, Rua Dr. Roberto Frias, Porto, 4200-465, Portugal

    João Manuel R. S. Tavares

  2. Fac. Engenharia, Lab. Engenharia de Processos,, Universidade do Porto, Rua Dr. Roberto Frias, Porto, 4200-465, Portugal

    R. M. Natal Jorge

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Lima, R., Fernandes, C.S., Dias, R., Ishikawa, T., Imai, Y., Yamaguchi, T. (2011). Microscale Flow Dynamics of Red Blood Cells in Microchannels: An Experimental and Numerical Analysis. In: Tavares, J., Jorge, R. (eds) Computational Vision and Medical Image Processing. Computational Methods in Applied Sciences, vol 19. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0011-6_17

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  • DOI: https://doi.org/10.1007/978-94-007-0011-6_17

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  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-0010-9

  • Online ISBN: 978-94-007-0011-6

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