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Spatial Point Process Analysis of Promyelocytic Leukemia Nuclear Bodies

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Advances in Nuclear Architecture

Abstract

There has been widespread interest in the nuclear body (NB) Promyelocytic leukemia (PML) because of its link to several human disorders, including Promyelocytic leukemia and AIDS. The notion of PML NB interaction with its surrounding and other NBs such as RNA Polymerase II (RNA Pol II) is of great importance as it can improve our understanding of the function of PML. In this paper, spatial point process methods are used to conduct multivariate analysis to assess the relationship between the spatial locations of PML NBs relative to RNA Pol II. We also propose a model for PML NB locations. By fitting a model to the PML NBs we are able to gain insight into how PML NBs are distributed across the nucleus in relation to themselves and the nuclear boundary.

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Acknowledgements

The authors would like to thank Dr. Niall Adams and Professor Paul Freemont for their substantial involvement in this work, and Dr. Elizabeth Batty and Dr Carol Shiels for their experimental work. David Stephens is supported by a Natural Sciences and Engineering Research Council of Canada (NSERC) Discovery Grant.

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Authors and Affiliations

  1. Department of Mathematics, Imperial College, 180 Queens Gate, London, SW7 2AZ, UK

    Philip P. Umande

  2. Department of Mathematics and Statistics, McGill University, 805 Sherbrooke Street West, Montreal, QC, H3A 2K6, Canada

    David A. Stephens

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  1. Philip P. Umande
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  2. David A. Stephens
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Correspondence to Philip P. Umande .

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Editors and Affiliations

  1. Department of Mathematics, Imperial College, Queen's Gate 180, London, SW7 2AZ, United Kingdom

    Niall M. Adams

  2. Div. Molecular Biosciences, Imperial College London, London, SW7 2AZ, United Kingdom

    Paul S. Freemont

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Umande, P.P., Stephens, D.A. (2011). Spatial Point Process Analysis of Promyelocytic Leukemia Nuclear Bodies. In: Adams, N., Freemont, P. (eds) Advances in Nuclear Architecture. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9899-3_2

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