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Imaging Mass Spectrometry

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Detection of Biological Agents for the Prevention of Bioterrorism

Abstract

Imaging Mass Spectrometry (IMS) is a powerful analytical technology that provides both molecular and spatial information from a single sample. This chapter provides a brief history of Imaging Mass Spectrometry, including early work with secondary ion mass spectrometry (SIMS) and laser desorption/ionization (LDI) techniques. A more in-depth account of recent applications utilizing matrix-assisted laser desorption/ionization (MALDI) mass spectrometry for high-molecular weight imaging is presented.

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Authors and Affiliations

  1. Mass Spectrometry Research Center, Vanderbilt University, Nashville, TN, 37232, United States

    Michelle L. Reyzer & Richard M. Caprioli

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  1. Michelle L. Reyzer
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  2. Richard M. Caprioli
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Correspondence to Michelle L. Reyzer .

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  1. , Science Branch, Fisheries and Oceans Canada, St. John's, A1C 5X1, Newfoundland and Labrador, Canada

    Joseph Banoub

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Reyzer, M.L., Caprioli, R.M. (2011). Imaging Mass Spectrometry. In: Banoub, J. (eds) Detection of Biological Agents for the Prevention of Bioterrorism. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9815-3_17

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