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Age-Related Remodeling of Neuromuscular Junctions

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Sarcopenia – Age-Related Muscle Wasting and Weakness

Abstract

Remodeling of neuromuscular junctions (NMJs) and ensuing ­structural and functional plasticity occurs with aging. Age-related changes result from ­reductions in physical activity, loss of motor neurons, and decreased muscle fiber size (sarcopenia). The properties of motor neurons and muscle fibers are precisely matched. In addition, motor unit recruitment in a selective manner is a primary mechanism by which the nervous system controls muscle contraction. Thus, it is essential to consider motor unit (and muscle fiber) type in any age-related ­plasticity. The following chapter examines changes in motor unit properties associated with aging and how these affect structural and functional remodeling at NMJs.

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Authors and Affiliations

  1. Departments of Physiology and Biomedical Engineering and Anesthesiology, College of Medicine, Mayo Clinic, St. Marys Hospital, Joseph 4W-184, 200 First Street SW, Rochester, MN, 55905, USA

    Carlos B. Mantilla & Gary C. Sieck

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  1. Carlos B. Mantilla
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  2. Gary C. Sieck
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Correspondence to Gary C. Sieck .

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  1. , Department of Physiology, The University of Melbourne, Melbourne, 3100, Victoria, Australia

    Gordon S. Lynch

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Mantilla, C.B., Sieck, G.C. (2011). Age-Related Remodeling of Neuromuscular Junctions. In: Lynch, G. (eds) Sarcopenia – Age-Related Muscle Wasting and Weakness. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9713-2_3

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