Abstract
Calcium-permeable AMPA receptors are proved to be expressed on carp retinal horizontal cells. However, the synaptic contribution and modulatory characteristics of these receptors in the synapses between cones and horizontal cells are not fully understood. In the present study, we used whole-cell patch clamp technique to test the functional contribution of calcium-permeable AMPA receptors and relevant zinc modulatory effect on these receptors. It is shown that application of 100 μM pentobarbital (a selective blocker of calcium-impermeable AMPA receptors) slightly but significantly suppressed the current elicited by 3 mM glutamate. Furthermore, the co-application of 300 μM zinc apparently inhibited the remaining calcium-permeable AMPA receptors. These results suggest that calcium-permeable AMPA receptors contribute a large portion to the cell’s glutamate-current and zinc can down-regulate the function of these receptors.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Huang, S.Y., Liang, P.J.: Ca2+-permeable and Ca2+-impermeable AMPA receptors coexist on horizontal cells. Neuroreport. 16 (2005) 263–266.
Redenti, S., Ripps, H., Chappell, R.L.: Zinc release at the synaptic terminals of rod photoreceptors. Exp. Eye Res. 85 (2007) 580–584.
Zhang, D.Q., Ribelayga, C., Mangel, S.C., McMahon, D.G.: Suppression by zinc of AMPA receptor-mediated synaptic transmission in the retina. J. Neurophysiol. 88 (2002) 1245–1251.
Jiang, X.D., Wang, X.L., Sun, Y., Gong, H.Q., Liang, P.J.: NMDA modulation of GABA transporter current in carp retinal horizontal cells. Brain Res. 1240 (2008) 105–110.
Taverna, F.A., Cameron, B.R., Hampson, D.L., Wang, L.Y., MacDonald, J.F.: Sensitivity of AMPA receptors to pentobarbital. Eur. J. Pharmacol. 267 (1994) R3–R5.
Huang, S.Y., Hu, J.F., Gong, H.Q., Liang, P.J.: Postsynaptic calcium pathway contributes to synaptic plasticity between retinal cones and luminosity-type horizontal cells. Sheng Li Xue Bao. 58 (2006) 407–414.
Acknowledgments
This work was supported by grants from National Foundation of Natural Science of China (No. 30870836) and Instrumental Analysis Center of SJTU.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Science+Business Media B.V.
About this paper
Cite this paper
Sun, Y., Jiang, XD., Xiao, L., Gong, HQ., Liang, PJ. (2011). Zinc Modulation of Calcium-Permeable AMPA Receptors on Carp Retinal Horizontal Cells. In: Wang, R., Gu, F. (eds) Advances in Cognitive Neurodynamics (II). Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9695-1_29
Download citation
DOI: https://doi.org/10.1007/978-90-481-9695-1_29
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-9694-4
Online ISBN: 978-90-481-9695-1
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)