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Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways

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Signal Transduction in Cancer Metastasis

Part of the book series: Cancer Metastasis - Biology and Treatment ((CMBT,volume 15))

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Abstract

In the tumor microenvironment, the primary tumor cells may recruit and interact with stromal cells and inflammatory cells including macrophages, mast cells and neutrophiles. A great multitude of growth factors, cytokines, chemokines and growth/motility factors may be secreted by aforementioned cells in the microenvironment to trigger epithelial-mesenchymal transition (EMT), migration and invasion of tumor cells and facilitate neovasculation and modifications of the ECM. Multiple signal pathway induced by various metastatic factors may be integrated to establish an amplified and sustained driving force for tumor progression. The first part of this review focus on the cellular and molecular processes occurring in the microenvironment that are fundamental for triggering the initiation stage of tumor metastasis. In the second part, altered signal pathways induced by several critical metastatic factors such as HGF, TGFβ and that elicited by integrin-ECM engagement are delineated. In the future, more effective cancer therapy can be developed by targeting the critical signal molecules responsible for the initiation stage of tumor metastasis.

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Authors and Affiliations

  1. Department of Medical Technology, Graduate Institute of Medicine, Tzu Chi University, Hualien, Taiwan

    Wen-Sheng Wu

  2. Institute of Medical Biotechnology, College of Medicine, Tzu Chi University, Hualien, Taiwan

    Wen-Sheng Wu

  3. Division of Gastroenterology, Department of Medicine, Buddhist Tzu Chi Hospital and University, Section 3, No.707, Chung-Yan Road, Hualien, Taiwan

    Chi-Tan Hu

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  1. Tzu-Chi University, College of Medicine, Institute of medical biotechnology, Chung-Yang Rd, Sec 3 701, Hualien, 970, Taiwan R.O.C.

    Wen-Sheng Wu

  2. Buddhist Tzu-Chi General Hospital, Department of Medicine, Research Center for Hepatology, Chung-Yang Rd, Sec 3 707, Hualien, 970, Taiwan R.O.C.

    Chi-Tan Hu

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Wu, WS., Hu, CT. (2010). Microenvironment Triggers EMT, Migration and Invasion of Primary Tumor via Multiple Signal Pathways. In: Wu, WS., Hu, CT. (eds) Signal Transduction in Cancer Metastasis. Cancer Metastasis - Biology and Treatment, vol 15. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9522-0_2

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