Abstract
Ribonucleotide reductases play a central role in DNA biosynthesis. They catalyze the conversion of NDPs (NTPs) to dNDPs (dNTPs) concomitant with oxidation of thiols within their active sites. A single active site can accomodate reduction of both purine and pyrimidine nucleotides. In addition to the transcriptional and translational controls and to the allosteric regulation of the enzyme activity, the overall regulation may imply the regulation of the production and destruction of auxiliary cofactors and proteins.
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Cohen, G.N. (2010). The Biosynthesis of Deoxyribonucleotides. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9437-7_34
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DOI: https://doi.org/10.1007/978-90-481-9437-7_34
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