Abstract
Riboswitches, mainly studied by the laboratories of Ronald Breaker (Yale) and Evgeny Nudler (New York University) are metabolite binding domains within certain messenger RNAs that serve as precision sensors for their corresponding targets. Allosteric rearrangement of mRNA structure is mediated by ligand binding, and this results in modulation of gene expression. Thus, mRNAs sense metabolites and control gene expression without the need for protein factors.
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Selected References
A. Nahvi, N. Sudarsan, M. S. Ebert, X. Zou, K. L. Brown and R. R. Breaker, Chem Biol., 9, 1043 (2002).
W. Winkler, A. Nahvi and R. R. Breaker, Nature, 419, 952–956 (2002).
A. S. Mironov, I. Gusarov, R. Rafikov, L. E. Lopez, K. Shatalin, R. A. Kreneva, D. A. Perumov and E. Nudler, Cell., 111, 747–756 (2002).
M. Mandal and R. R. Breaker, Nat. Rev. Cell. Biol., 5, 451–463 (2004).
A. Serganov, A. Polonskaia, A. T. Phan, R. R. Breaker and D. J. Patel, Nature, 441, 1167–1171 (2006)
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Cohen, G.N. (2010). Riboswitches. In: Microbial Biochemistry. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9437-7_22
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DOI: https://doi.org/10.1007/978-90-481-9437-7_22
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