Abstract
Selective internal radiation therapy (SIRT) is a new and effective loco-regional anticancer treatment option for advanced cancer patients with liver metastases or liver cancer. In a prospective study, blood samples were taken from 112 patients with extensive hepatic metastases from various primary tumors (49 colorectal, 22 breast, 15 cholangiocellular and pancreatic, 7 carcinoid, 13 others) or with primary hepatic cancer (n = 6) before, and 3, 6, 24 and 48 h after SIRT. Circulating nucleosomes were determined by ELISA and the patterns of nucleosome release in the different groups of primary cancers were compared. Serum nucleosomes showed significant increases already 24 h after SIRT (p < 0.001) and remained high after 48 h (p < 0.001). Those early increases were observed in all patient groups irrespective of the various primary tumors. However, they started from different pre-therapeutic absolute nucleosome levels that may reflect diverse biological properties of the various tumor diseases. Circulating nucleosomes are increased early after application of SIRT. Their relevance for prediction of therapy response and estimation of prognosis has to be shown in prospective studies.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
American Cancer Society. Breast Cancer Facts & Figures 2007–2008. Atlanta: American Cancer Society, Inc. http://www.cancer.org/downloads/STT/BCFF-Final.pdf
Breedis C, Young G (1954) The blood supply of neoplasms in the liver. Am J Pathol 30:969–977
Campbell AM, Bailey IH, Burton MA (2001) Tumor dosimetry in human liver following hepatic yttrium-90 microsphere therapy. Phys Med Med Biol 46:487–498
Holdenrieder S, Stieber P (2009) Clinical use of circulating nucleosomes. Crit Rev Lab Med Sci 46:1–24
Holdenrieder S, Stieber P, Bodenmuller H et al (2001) Nucleosomes in serum as a marker for cell death. Clin Chem Lab Med 39:596–605
Holdenrieder S, Stieber P, von Pawel J et al (2004) Circulating nucleosomes predict the response to chemotherapy in patients with advanced non-small cell lung cancer. Clin Cancer Res 10:5981–5987
Holdenrieder S, von Pawel J, Dankelmann E et al (2008) Nucleosomes, ProGRP, NSE, CYFRA 21-1 and CEA in the therapy monitoring of small-cell lung cancer during first-line chemotherapy. Clin Cancer Res 14:7813-7821
Kennedy AS, Nutting C, Coldwell D et al (2004) Pathologic response and microdosimetry of (90)Y microspheres in man: review of four explanted whole livers. Int J Radiat Oncol Biol Phys 60:1552–1563
Kremer A, Wilkowski R, Holdenrieder S et al (2005) Nucleosomes in pancreatic cancer patients during radiochemotherapy. Tumor Biol 26:44–49
Leung TW, Lau WY, Ho SK et al (1995) Radiation pneumonitis after selective internal radiation treatment with intraarterial 90 yttrium-microspheres for inoperable hepatic tumors. Int J Radiat Oncol Biol Phys 33:919–924
Schlag PM, Benhidjeb T, Stroszczynski C (2002) Resection and local therapy for liver metastases. Best Pract Res Clin Gastroenterol 16:299–317
Townsend A, Price T, Karapetis C (2009) Selective internal radiation therapy for liver metastases from colorectal cancer. Cochrane Database Syst Rev 4:CD007045
Acknowledgment
The work is part of the doctoral thesis of Yvonne Fehr.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media B.V.
About this paper
Cite this paper
Fehr, Y. et al. (2010). Circulating Nucleosomes in Cancer Patients with Liver Metastases Undergoing Selective Internal Radiation Therapy Using Yttrium-90 Labelled Microspheres. In: Gahan, P. (eds) Circulating Nucleic Acids in Plasma and Serum. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9382-0_13
Download citation
DOI: https://doi.org/10.1007/978-90-481-9382-0_13
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-90-481-9381-3
Online ISBN: 978-90-481-9382-0
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)