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Histamine: Role in Pathogenesis of Autoimmune, Allergic, Inflammatory and Malignant Diseases

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Biomedical Aspects of Histamine

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Abstract

Recent years have witnessed importance of histamine in immunopathophysiological implications in several diseases. Moreover, its role in development of disease pathology is still being elucidated. Accumulating evidences have highlighted that histamine has the possible role in pathology of autoimmunity by modulating the cytokine network and influence T-lymphocytes (Th1 and Th2) balance, and antibody isotype switching. Hence, there is a real need to search for newer role of histamine in disease development. In this review, we will highlight histamine role in pathology of autoimmunity and its mechanism, and also histamine role in pathogenesis of autoimmune, allergic, inflammatory and malignant diseases such as chronic urticaria (CU), atopic dermatitis (AD), autoimmune myocardium (AM) and multiple sclerosis (MS) & experimental autoimmune encephalomyelitis (EAE); allergic rhinitis, anaphylaxis (acute) and asthma; atherosclerosis; and malignant melanoma, respectively. There are several steps in the autoimmune attack/allergic march where histamine might play an important role.

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Abbreviations

HDC:

histidine decarboxylase enzyme

IL:

interleukin

GM-CSF:

granulocyte-monocyte colony stimulating factor

CU:

chronic urticaria

CAU:

chronic autoimmune urticaria

AD:

atopic dermatitis

AM:

autoimmune myocardium

MS:

multiple sclerosis

EAE:

experimental autoimmune encephalomyelitis

MHC:

major histocompatibility complex

H1R:

histamine receptor 1

H2R:

histamine receptor 2

H3R:

histamine receptor 3

H4R:

histamine receptor 4

EAO:

experimental autoimmune orchitis

Th1:

T helper 1

Th2:

T helper 2

SPZ:

streptozotocin

TNF:

tumor necrosis factor

IgG:

immunoglobulin-G

IgE:

immunoglobulin-E

ThEA:

2-thiazolylethylamine

CNS:

central nervous system

MBP:

myelin basic protein

HRs:

histamine receptors

MOG:

myelin oligodendrocyte glycoprotein

cGMP:

cyclic guanosine monophosphate

SCID:

severe combined immunodeficient

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Acknowledgments

Trivendra Tripathi acknowledges University Grants Commission, New Delhi, India for providing UGC Fellowship [UGC letter DON F. 19-33/2006 (CU)] and M. Shahid is grateful to Department of Science and Technology, Ministry of Science and Technology, Government of India for awarding “Young Scientist Project Award” (FT/SR-L-111/2006).

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Authors and Affiliations

  1. Department of Biochemistry, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, UP, India

    Trivendra Tripathi & Mashiatullah Siddiqui

  2. Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, UP, India

    Mohammed Shahid & Haris M. Khan

  3. Department of Anatomy, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, UP, 202002, India

    Aijaz Ahmed Khan

  4. Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, UP, 202002, India

    Rahat Ali Khan

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  1. School of Medicine, Dept. Internal Medicine, Southern Illinois University, N. Rutledge 751, Springfield, 62702, Illinois, USA

    Nancy Khardori

  2. J. N. Medical College, Dept. Pharmacology, Aligarh Muslim University, Aligarh, 202002, India

    Rahat Ali Khan

  3. Jawaharlal Nehru Medical College &, Hospital, Aligarh Muslim University, Aligarh, 202002, India

    Trivendra Tripathi

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© 2010 Springer Science+Business Media B.V.

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Tripathi, T., Shahid, M., Khan, H.M., Siddiqui, M., Khan, A.A., Khan, R.A. (2010). Histamine: Role in Pathogenesis of Autoimmune, Allergic, Inflammatory and Malignant Diseases. In: Khardori, N., Khan, R., Tripathi, T. (eds) Biomedical Aspects of Histamine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9349-3_9

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