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Immune Regulation by Various Facets of Histamine in Immunomodulation and Allergic Disorders

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Biomedical Aspects of Histamine

Abstract

Histamine has tremendous biological role, mediated by four types of histamine receptors (H1R–H4R) on secretion by effector cells (mast cells and basophils) through various immunological and non-immunological stimuli. Their patho-physiological implication in all facets of biomedical areas have been reported extensively. It shows proinflammatory or anti-inflammatory effects, depending on the predominance of the types of histamine receptors. It had proinflammatory activity through the H1R, and is involved in the development of various aspects of antigen-specific immune response including the maturation of dendritic cells and the modulation of the balance of type 1 helper (Th1) T cells and type 2 helper (Th2) T cells. Histamine blocks humoral immune responses by means of a specific mechanism in which it induces an increase in the proliferation of Th1 cells and in the production of interferon-γ. Histamine stimulates the release of proinflammatory cytokines and lysosomal enzymes from human macrophages and shows the capacity to influence the activity of immune cells including mast cells, basophils, eosinophils, fibroblasts, lymphocytes, neutrophils, epithelial and endothelial cells, and plays a pivotal role in allergic inflammation which is a complex network of cellular events and involves redundant mediators and signals. In this chapter, we tried to elaborate the newer discoveries of histamine H1–H4-receptors in immunomodulation and allergic conditions, and effect of histamine in immune cells with respect to allergic diseases. We hope that this article would stimulate discussions and active research on this important aspect.

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Acknowledgments

Trivendra Tripathi acknowledges University Grants Commission, New Delhi, India for providing UGC Fellowship [UGC letter DON F. 19-33/2006 (CU)] and M. Shahid is grateful to Department of Science and Technology, Ministry of Science and Technology, Government of India for awarding “Young Scientist Project Award” (FT/SR-L-111/2006).

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Authors and Affiliations

  1. Department of Biochemistry, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, UP, India

    Trivendra Tripathi & Mashiatullah Siddiqui

  2. Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, UP, India

    Mohammed Shahid

  3. Department of Microbiology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, UP, India

    Farrukh Sobia, Anuradha Singh & Haris M. Khan

  4. Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, UP, India

    Rahat Ali Khan

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  1. Trivendra Tripathi
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  2. Mohammed Shahid
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  3. Farrukh Sobia
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  4. Anuradha Singh
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  5. Haris M. Khan
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  6. Rahat Ali Khan
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  7. Mashiatullah Siddiqui
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Correspondence to Mohammed Shahid .

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Editors and Affiliations

  1. School of Medicine, Dept. Internal Medicine, Southern Illinois University, N. Rutledge 751, Springfield, 62702, Illinois, USA

    Nancy Khardori

  2. J. N. Medical College, Dept. Pharmacology, Aligarh Muslim University, Aligarh, 202002, India

    Rahat Ali Khan

  3. Jawaharlal Nehru Medical College &, Hospital, Aligarh Muslim University, Aligarh, 202002, India

    Trivendra Tripathi

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Tripathi, T. et al. (2010). Immune Regulation by Various Facets of Histamine in Immunomodulation and Allergic Disorders. In: Khardori, N., Khan, R., Tripathi, T. (eds) Biomedical Aspects of Histamine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9349-3_6

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