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The Neuronal Histamine and it’s Receptors as New Therapeutic Targets for Food Intake and Obesity

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Abstract

Histamine neurons and histamine receptors have distributed in the brain and addressed in their implications of regulatory energy homeostasis. Several studies using agonist/antagonist of neuronal histamine and it’s receptors demonstrated that they have been shown to be involved in food intake and obesity. In addition, adipocytokine leptin regulates food intake and obesity partially via neuronal histamine and it’s receptors. Furthermore, recent studies have provided evidence that regulation of the diurnal rhythm of food intake through neuronal histamine is a crucial factor in the development of obesity. Thus, we focused on these roles of the neuronal histamine and it’s receptors in regulating the food intake and obesity.

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Abbreviations

TMN:

tuberomammillary nucleus

HDC:

histidine decarboxylase

IP3:

inositol-1,4,5-triphosphate

DAG:

1,2-diacylglycerol

cAMP:

cyclic adenosine monophosphate

α-FMH:

alpha-fluoromethylhistidine

PVN:

paraventricullar nucleus

UCPs:

uncoupling proteins

IAs:

inverse agonists

VLPO:

ventrolateral preoptic nucleus

REM:

rapid eye movement

WT:

wild-type

ARC:

arcuate nucleus

VMH:

ventromedial nucleus

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Authors and Affiliations

  1. Department of Internal Medicine, Oita University, 1-1 Idaigaoka, Yufu-Hasama, Oita, 879-5593, Japan

    Takayuki Masaki

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  1. Takayuki Masaki
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Correspondence to Takayuki Masaki .

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Editors and Affiliations

  1. School of Medicine, Dept. Internal Medicine, Southern Illinois University, N. Rutledge 751, Springfield, 62702, Illinois, USA

    Nancy Khardori

  2. J. N. Medical College, Dept. Pharmacology, Aligarh Muslim University, Aligarh, 202002, India

    Rahat Ali Khan

  3. Jawaharlal Nehru Medical College &, Hospital, Aligarh Muslim University, Aligarh, 202002, India

    Trivendra Tripathi

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Masaki, T. (2010). The Neuronal Histamine and it’s Receptors as New Therapeutic Targets for Food Intake and Obesity. In: Khardori, N., Khan, R., Tripathi, T. (eds) Biomedical Aspects of Histamine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9349-3_13

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