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Biological Characteristics of Histamine Receptors in Airways Disease Management

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Biomedical Aspects of Histamine

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Abstract

Histamine, a biogenic amine is an important mediator isolated from ergot extracts and released from activated mast cells provoked by allergen and has a substantial role in the pathophysiology of asthma. It not only mediates multiple biological actions but also play an important role in vascular dilatation and smooth muscles contraction during anaphylaxis. Cell growth and differentiation, a significant event in the biological system have been regulated by its receptors both in normal and transformed tissues. The discovery of noble histamine H4-receptors prompted us to reinvestigate the role of histamine in pulmonary allergic responses. In asthma and other types of allergic inflammation, mast cells and basophils are the postulated major sources of histamine. In this chapter, we would highlight the potential histamine role in airways diseases and try to update the current aspects of histamine in asthma and fill the gap in existing literature.

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Abbreviations

DCs:

dendritic cells

Th1:

T helper 1 cells

Th2:

T helper 2 cells

IFN-γ:

interferon gamma

MHC II:

major histocompatibility complex class II antigens

GM-CSF:

granulocyte macrophage colony-stimulating factor

IL:

interleukine

HDC:

histidine decarboxylase

IgE:

immunoglobulin-E

COAD:

chronic obstructive airways disease

AHR:

airway hyper responsiveness

MCs:

mast cells

COPD:

chronic obstructive pulmonary disease

ETS:

environmental tobacco smoke

HNMT:

histamine N-methyltransferase

H1:

histamine H1-receptor

H2:

histamine H2 receptor

H3:

histamine H3 receptor

H4:

histamine H4 receptor

CXCl12:

chemokine (C-X-C motif) ligand 12

OVA:

ovalumin

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Acknowledgement

This work is supported by the Council of Science and Technology, Uttar Pradesh, Lucknow, India (CST/SEPRD/D-3404).

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Authors and Affiliations

  1. Department of Pulmonary Medicine, C.S.M. Medical University, Erstwhile King George’s Medical University, Lucknow, UP, India

    Rajni Kant Shukla & Priyanka Jain

  2. Department of Physiology, C.S.M. Medical University, Erstwhile King George’s Medical University, Lucknow, UP, India

    Sandeep Bhattacharya

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  1. Rajni Kant Shukla
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  2. Priyanka Jain
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  3. Sandeep Bhattacharya
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Correspondence to Sandeep Bhattacharya .

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Editors and Affiliations

  1. School of Medicine, Dept. Internal Medicine, Southern Illinois University, N. Rutledge 751, Springfield, 62702, Illinois, USA

    Nancy Khardori

  2. J. N. Medical College, Dept. Pharmacology, Aligarh Muslim University, Aligarh, 202002, India

    Rahat Ali Khan

  3. Jawaharlal Nehru Medical College &, Hospital, Aligarh Muslim University, Aligarh, 202002, India

    Trivendra Tripathi

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Shukla, R.K., Jain, P., Bhattacharya, S. (2010). Biological Characteristics of Histamine Receptors in Airways Disease Management. In: Khardori, N., Khan, R., Tripathi, T. (eds) Biomedical Aspects of Histamine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9349-3_10

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