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Biomedical Aspects of Histamine pp 3–13Cite as

An Overview of Histamine Synthesis, Regulation and Metabolism, and its Clinical Aspects in Biological System

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Abstract

Histamine is an autacoid widespread in plant and animal kingdoms. In the early 1900s, it was identified as a mediator of biological functions by Sir Henry Dale and co-workers and drugs targeting histamine receptors have been in clinical use for more than 60 years. The synthesis of histamine was discovered by Windausa and Vogta in 1907. Its synthesis, regulation and metabolism causes numerous biological effects. This chapter will provide an overview of histamine synthesis, regulation and metabolism, and the biological effects thereof.

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Abbreviations

HDC:

histidine decarboxylase

ECL:

enterochromaffin-like cells

DCs:

dendritic cells

IL:

interleukin

GM-CSF:

granulocyte monocyte-colony stimulating factor

TNF:

tumour necrosis factor

LPS:

lipopolysaccharide

BMMCs:

bone marrow derived mast cells

IgE:

immunoglobulin-E

PKC:

protein kinase C

cDNAs:

complementary deoxyribonucleic acids

PMA:

phorbol 12-myristate 13-acetate

MAP:

mitogen-activated protein

ERK:

extracellular signal-regulated protein kinase

mRNA:

messenger ribonucleic acids

ECL:

enterochromaffin-like cells

HMT:

histamine N τ-methyltransferase

DAO:

diamine oxidase

H1R:

histamine H1-receptor

H2R:

histamine H2-receptor

H3R:

histamine H3-receptor

H4R:

histamine H4-receptor

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Acknowledgement

Trivendra Tripathi acknowledges University Grants Commission, New Delhi, India for providing UGC Fellowship [UGC letter DON F. 19-33/2006 (CU)].

Author information

Authors and Affiliations

  1. Department of Microbiology, Faculty of Medicine, J.N.Medical College & Hospital, Aligarh Muslim University, Aligarh, UP, 202002, India

    Mohammed Shahid

  2. Department of Biochemistry, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, 202002, UP, India

    Trivendra Tripathi

  3. Division of Infectious Diseases, Department of Internal Medicine, School of Medicine, Southern Illinois University, Springfield, IL, USA

    Nancy Khardori

  4. Department of Pharmacology, Jawaharlal Nehru Medical College and Hospital, Aligarh Muslim University, Aligarh, UP, 202002, India

    Rahat Ali Khan

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  1. Mohammed Shahid
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  4. Rahat Ali Khan
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Corresponding author

Correspondence to Mohammed Shahid .

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Editors and Affiliations

  1. School of Medicine, Dept. Internal Medicine, Southern Illinois University, N. Rutledge 751, Springfield, 62702, Illinois, USA

    Nancy Khardori

  2. J. N. Medical College, Dept. Pharmacology, Aligarh Muslim University, Aligarh, 202002, India

    Rahat Ali Khan

  3. Jawaharlal Nehru Medical College &, Hospital, Aligarh Muslim University, Aligarh, 202002, India

    Trivendra Tripathi

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Shahid, M., Tripathi, T., Khardori, N., Khan, R.A. (2010). An Overview of Histamine Synthesis, Regulation and Metabolism, and its Clinical Aspects in Biological System. In: Khardori, N., Khan, R., Tripathi, T. (eds) Biomedical Aspects of Histamine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9349-3_1

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