Abstract
Electroporation EP, in which external electric field pulses create transient pores in a cell membrane, is an important technique for delivery of genes and drugs into the cell. To enable a useful level of entry of genes into cells, the pores should have sufficiently large radii, and remain open long enough without causing membrane rupture. A numerical model for a single spherical cell electroporated by application of direct and/or alternating external electric field pulses has been developed. The model is used to indicate the actual number of pores and their radii distribution developed in response to various electric field pulses, as function of time and position on the cell surface. This study briefly describes the model briefly which is then used to investigate the ability to control the number and distribution of pore radii by choice of electric field parameters. We believe this would be one of the first papers to investigate the ability to CONTROL the number and distribution (range) of pore radii (as opposed to other papers that merely report the pore number and range with varying pulse parameters.
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Talele, S., Gaynor, P. (2010). Modelling Control of Pore Number and Radii Distribution in Single-Cell Electroporation. In: Elleithy, K., Sobh, T., Iskander, M., Kapila, V., Karim, M., Mahmood, A. (eds) Technological Developments in Networking, Education and Automation. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9151-2_40
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DOI: https://doi.org/10.1007/978-90-481-9151-2_40
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