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Banking of Cord Blood

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Essentials of Tissue Banking

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Abstract

Hematopoietic stem cell transplantation (HSCT) can be curative in a large variety of selected malignant and non malignant diseases. Umbilical cord blood transplantation (UCBT) has extended the availability of allogeneic hematopoietic stem cell transplantation (HSCT) to patients who would not otherwise be eligible for this curative approach. The first successful UCBT from an HLA-identical sibling in a child with severe Fanconi’s anemia was reported by Gluckman et al. in 1989 [1]. This first success opened the way to a new field in the domain of allogeneic HSCT as it showed that: (1) a single umbilical cord blood contained enough hematopoietic stem cells to reconstitute definitely the host lympho-hematopoietic compartment; (2) an umbilical cord blood unit could be collected at birth without any harm to the new-born infant, and (3) umbilical cord blood hematopoietic stem cells could be cryopreserved and transplanted in a myeloablated host after thawing without losing their repopulating capacity. Since, our knowledge on the biological characteristics of umbilical cord blood cells has increased, emphasizing the advantages of using umbilical cord blood stem cells for transplant. Simultaneously, umbilical cord blood banks (CBB) have been established for related or unrelated UCBT with more than 500,000 units available and more than 20,000 umbilical cord blood transplants performed in children and in adults with malignant and non malignant diseases.

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Authors and Affiliations

  1. Eurocord, Hematology Department, APHP University Paris VII, Paris, France

    Eliane Gluckman

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  1. Eliane Gluckman
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Correspondence to Eliane Gluckman .

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  1. Service, Scottish National Blood Transfusion, Ellens Glen Road, Edinburgh, EH17 7QT, United Kingdom

    George Galea

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Gluckman, E. (2010). Banking of Cord Blood. In: Galea, G. (eds) Essentials of Tissue Banking. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9142-0_3

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