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Induced Pluripotent Stem Cells

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Regenerative Medicine

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Abstract

Nearly 50 years have passed since the concept of nuclear ­reprogramming was proposed for the first time. Since then, several approaches have been developed to convert somatic cells to a pluripotent state. Direct reprogramming with defined factors, is the newest of these approaches. This method requires just a few genes, and it also has a great reproducibility. Applying this method to humans seems to open the door to cell transplantation therapy without immune rejection, drug ­discovery, and elucidation of the pathogenesis of intractable diseases. However, this concept still faces some issues which must be overcome before application due to a shortage of experience. This chapter introduces an overview of direct reprogramming as well as a special focus on its potentials and challenges.

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Acknowledgement

We’d like to thank the members of the Yamanaka laboratory and CiRA for their valuable support and discussions. We are also grateful to Dr. Tetsuya Ishii and Kanon Takeda for their critical reading of the manuscript.

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Authors and Affiliations

  1. Center for iPS cell Research and Application, Institute for Integrated Cell-Material Sciences, Kyoto University, Kyoto, 606-8507, Japan

    Kazutoshi Takahashi & Shinya Yamanaka

  2. Department of Stem Cell Biology, Institute for Frontier Medical Sciences, Kyoto University, Kyoto, 606-8507, Japan

    Shinya Yamanaka

  3. Yamanaka iPS Cell Special Project, Japan Science and Technology Agency, Kawaguchi, 332-0012, Japan

    Shinya Yamanaka

  4. Gladstone Institute of Cardiovascular Disease, San Francisco, CA, 94158, USA

    Shinya Yamanaka

Authors
  1. Kazutoshi Takahashi
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  2. Shinya Yamanaka
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Editors and Affiliations

  1. Klinik und Poliklinik für Herzchirurgie, Universitätsklinikum Rostock, Schillingallee 35, Rostock, 18057, Germany

    Gustav Steinhoff

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Takahashi, K., Yamanaka, S. (2011). Induced Pluripotent Stem Cells. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9075-1_8

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