Abstract
Recent discoveries in stem cell biology have generated excitement about the possibility of harnessing stem cells for repair and regeneration of lung diseases. Although initial emphasis was on engraftment of stem cells in lung, more recent studies demonstrate that mesenchymal stem cells (MSCs) can modulate local inflammatory and immune responses in experimental lung disease models including acute lung injury and pulmonary fibrosis via a paracrine activity. Endothelial progenitor cells also seem to contribute to lung repair and are used in clinical trials for the treatment of pulmonary hypertension. The ability to produce stem cells by induced pluripotency may relieve many ethical concerns related to the use of embryonic stem cells and may open the way to large-scale production and evaluation of pluripotent stem cells for lung regeneration and repair. The aim of this review is to provide a summary of the recent progress made in the field of lung regeneration using different approaches including stem cell-based therapy and lung tissue bioengineering.
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Coltan, L., Thébaud, B. (2011). Lung. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9075-1_30
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