Abstract
Generation and regeneration as an answer to disease are far from being a new idea. Philosophers, naturalists and scientists were intrigued by the marvels of regeneration seen in nature. By the middle of the nineties life scientists thought we were only a few years away from bioartificial organs grown in a Petri dish. However, by the dawn of the new millennium it became clear that the mechanistic approach dictated by tissue engineering so far, had neglected issues of vascularization. Processes of angiogenesis were central to homeostasis, bioassimilation and biointegration of tissue engineered constructs. Furthermore, the field of tissue engineering had evolved into something vast, encompassing satellite technologies that were becoming separate science sectors. Advances in genetical engineering, stem cell biology, cloning, biomaterials and biomedical devices to name a few, would come to play a major role of their own – tissue engineering had become a part of a bigger whole. Regenerative medicine is the collective field to shelter these technologies “…that seeks to develop functional cell, tissue, and organ substitutes to repair, replace or enhance biological function that has been lost due to congenital abnormalities, injury, disease, or aging”
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Notes
- 1.
Now the phenomenon of desquamation of the intestinal epithelium and the epidermis has been described. The intestinal epithelium is completely regenerated in 4–5 days. The total regeneration of the epidermis takes 4 weeks. This may mean that for a life expectancy of 77 years, the human epidermis is regenerated 1,000 times.
References
Aeschylus, Prometheus bound. 415 BC.
Andrews, P.W., Human teratocarcinomas. Biochim Biophys Acta, 1988. 948(1): p. 17–36.
Aristotle, The complete works: the revised Oxford edition. Bollingen series LXXI.2, ed. J. Barnes. 1984 Princeton, NJ: Princeton University Press.
Arnst, C. and J. Carey, Biotech bodies, in Bus Week. 1998. p. 56.
Asenjo, A., Neurosurgical techniques. 1963, Springfield: Charles C Thomas.
Barth, A., Ueber histologische Befunde nach Knochenimplantationen. Arch Klin Chir, 1893. 46: p. 409–417.
Beier, J.P., D. Klumpp, M. Rudisile, R. Dersch, J.H. Wendorff, O. Bleiziffer, A. Arkudas, E. Polykandriotis, R.E. Horch, and U. Kneser, Collagen matrices from sponge to nano: new perspectives for tissue engineering of skeletal muscle. BMC Biotechnol, 2009. 9: p. 34.
Bell, E., H.P. Ehrlich, D.J. Buttle, and T. Nakatsuji, Living tissue formed in vitro and accepted as skin-equivalent tissue of full thickness. Science, 1981. 211(4486): p. 1052–4.
California proposition 71 (2004). Wikipedia (cited 2009 10 August).
Caplan, A.I., The mesengenic process. Clin Plast Surg, 1994. 21(3): p. 429–35.
Carpue, J., An account of two successful operations for restoring a lost nose from the Integuments of the forehead., in Classics of Medicine Library. 1981(1816): Birmingham.
Coleman, W., Biology in the nineteenth century: Problems of form, function and transformation. 2nd ed. Cambridge History of Science Series. 1978: Cambridge University Press.
Daar, A.S. and H.L. Greenwood, A proposed definition of regenerative medicine. J Tissue Eng Regen Med, 2007. 1(3): p. 179–84.
Damjanov, I., Teratocarcinoma: neoplastic lessons about normal embryogenesis. Int J Dev Biol, 1993. 37(1): p. 39–46.
Dinsmore, E., A history of regeneration research: Milestones in the evolution of a science. 1991: Cambridge University Press.
Evans, M.J. and M.H. Kaufman, Establishment in culture of pluripotential cells from mouse embryos. Nature, 1981. 292(5819): p. 154–6.
Goldwyn, R.M., Johann Friedrich Dieffenbach (1794–1847). Plast Reconstr Surg, 1968. 42(1): p. 19–28.
Guillot, P.V., W. Cui, N.M. Fisk, and D.J. Polak, Stem cell differentiation and expansion for clinical applications of tissue engineering. J Cell Mol Med, 2007. 11(5): p. 935–44.
Hayflick, L., Entropy explains aging, genetic determinism explains longevity, and undefined terminology explains misunderstanding both. PLoS Genet, 2007. 3(12): p. e220.
Horch, R.E., H. Bannasch, and G.B. Stark, Transplantation of cultured autologous keratinocytes in fibrin sealant biomatrix to resurface chronic wounds. Transplant Proc, 2001. 33(1–2): p. 642–4.
Kaiser, L.R., The future of multihospital systems. Top Health Care Financ, 1992. 18(4): p. 32–45.
Kemp, P., History of regenerative medicine: looking backwards to move forwards. Regen Med, 2006. 1(5): p. 653–69.
Kleinsmith, L.J. and G.B. Pierce, Jr., Multipotentiality of single embryonal carcinoma cells. Cancer Res, 1964. 24: p. 1544–51.
Kratz, G. and F. Huss., Tissue engineering – body parts from the Petri dish. Scand J Surg, 2003. 92(4): p. 241–7.
Langer, R. and J.P. Vacanti, Tissue engineering. Science, 1993. 260(5110): p. 920–6.
Leff, D., New biological assembly line, in the cell: interand intra-relationships. 1983, Avery Publishing Group: New Jersey.
Longmate, B., Curious chirurgical operation: New nose. Gentlemen’s Magazine and Historical Chronicle, 1794. 64: p. 891
Lysaght, M.J. and J. Crager, Origins. Tissue Eng Part A, 2009. 15(7): p. 1449–50.
Lysaght, M.J. and A.L. Hazlehurst, Tissue engineering: the end of the beginning. Tissue Eng, 2004. 10(1–2): p. 309–20.
Martin, G.R., Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci USA, 1981. 78(12): p. 7634–8.
Mason, C., Regenerative medicine 2.0. Regen Med, 2007. 2(1): p. 11–8.
Mason, C. and P. Dunnill, The strong financial case for regenerative medicine and the regen industry. Regen Med, 2008. 3(3): p. 351–63.
Matsuda, T., T. Akutsu, K. Kira, and H. Matsumoto, Development of hybrid compliant graft: rapid preparative method for reconstruction of a vascular wall. ASAIO Trans, 1989. 35(3): p. 553–5.
Matthews, L.G., SS. cosmas and damian – Patron Saints of medicine and pharmacy their cult in England. Med Hist, 1968. 12(3): p. 281–8.
Moffatt, S.L., V.A. Cartwright, and T.H. Stumpf, Centennial review of corneal transplantation. Clin Exp Ophthalmol, 2005. 33(6): p. 642–57.
Mooney, D.J. and A.G. Mikos, Growing new organs. Sci Am, 1999. 280(4): p. 60–5.
Nerem, R.M., Tissue engineering in the USA. Med Biol Eng Comput, 1992. 30(4): p. CE8–12.
Newth, D., New (and better?) parts for old. In New Biology, M. Johnson, M. Abercrombie, and G. Fogg, Editors. 1958, Harmondsworth (UK): Penguin Books: London.
Old Lestament, Genesis. I:1. p. 21–22.
Papaioannou, V.E., M.W. McBurney, R.L. Gardner, and M.J. Evans, Fate of teratocarcinoma cells injected into early mouse embryos. Nature, 1975. 258(5530): p. 70–73.
Pera, M.F., S. Cooper, J. Mills, and J.M. Parrington, Isolation and characterization of a multipotent clone of human embryonal carcinoma cells. Differentiation, 1989. 42(1): p. 10–23.
Petrakova, K.V., A.A. Tolmacheva, and F. AIa (Bone formation occurring in bone marrow transplantation in diffusion chambers). Biull Eksp Biol Med, 1963. 56: p. 87–91.
Polykandriotis, E., A. Arkudas, R.E. Horch, M. Sturzl, and U. Kneser, Autonomously vascularized cellular constructs in tissue engineering: opening a new perspective for biomedical science. J Cell Mol Med, 2007. 11(1): p. 6–20.
Polykandriotis, E., J. Tjiawi, S. Euler, A. Arkudas, A. Hess, K. Brune, P. Greil, A. Lametschwandtner, R.E. Horch, and U. Kneser, The venous graft as an effector of early angiogenesis in a fibrin matrix. Microvasc Res, 2008. 75(1): p. 25–33.
Santayana, G., Reason in common sense, in The life of reason. 1905, Charles Scribner’s Sons: New York. p. 284.
Skalak, R. and C. Fox, Tissue engineering. Proceedings of a workshop held at Granlibakken, Lake Tahoe, California. 1989, New York: Liss.
Stocum, D., An overview of regenerative biology and medicine, in Regenerative biology and medicine. 2006, Academic: Oxford. p. 1–20.
Thomson, J.A., J. Kalishman, T.G. Golos, M. Durning, C.P. Harris, and J.P. Hearn, Pluripotent cell lines derived from common marmoset (Callithrix jacchus) blastocysts. Biol Reprod, 1996. 55(2): p. 254–9.
Thomson, J.A., J. Itskovitz-Eldor, S.S. Shapiro, M.A. Waknitz, J.J. Swiergiel, V.S. Marshall, and J.M. Jones, Embryonic stem cell lines derived from human blastocysts. Science, 1998. 282(5391): p. 1145–7.
Vacanti, C.A., The history of tissue engineering. J Cell Mol Med, 2006. 10(3): p. 569–76.
Vacanti, J.P., R. Langer, J. Upton, and J.J. Marler, Transplantation of cells in matrices for tissue regeneration. Adv Drug Deliv Rev, 1998. 33(1–2): p. 165–182.
Weaver, C.V. and D.J. Garry, Regenerative biology: a historical perspective and modern applications. Regen Med, 2008. 3(1): p. 63–82.
What will be the 10 hottest jobs? (cited 2009 08.20); Available from: http://www.time.com/time/reports/v21/work/mag_ten_hottest_jobs.html.
Wilmut, I., A.E. Schnieke, J. McWhir, A.J. Kind, and K.H. Campbell, Viable offspring derived from fetal and adult mammalian cells. Nature, 1997. 385(6619): p. 810–3.
Witkowski, J.A., Dr. Carrel’s immortal cells. Med Hist, 1980. 24(2): p. 129–42.
Wohlrab, F. and U. Henoch, The life and work of Carl Weigert (1845–1904) in Leipzig 1878–1885. Zentralbl Allg Pathol, 1988. 134: p. 743–751.
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Horch, R.E., Popescu, L.M., Polykandriotis, E. (2011). History of Regenerative Medicine. In: Steinhoff, G. (eds) Regenerative Medicine. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9075-1_1
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