Abstract
Meningococcal septicaemia and meningitis are the most common presentations of invasive meningococcal disease with an average case fatality rate of 10%, although arthritis and pericarditis can also occur. Early antibiotic therapy is strongly recommended, but this decreases the success of conventional diagnostic methodologies, i.e. culture. Culturing should however still be performed as it allows for the monitoring of changes in antimicrobial susceptibility. Molecular detection methods have allowed accurate, rapid diagnosis which enhances patient care and the initiation of public health action among contacts. The increased sensitivity offered by molecular detection and the ability to detect non-viable organisms may be responsible for increasing the diagnosis of laboratory confirmed cases of meningococcal disease by more than 30% [1]. Meningococcal DNA in CSF samples has been detected up to 72 h after commencement of antimicrobial treatment [1].
Keywords
- Meningococcal Disease
- Neisseria Meningitidis
- Public Health Action
- Invasive Meningococcal Disease
- Enhance Patient Care
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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Bryant PA, Hua YL, Zaia A et al (2004) Prospective study of a real-time PCR that is sensitive, specific, and clinically useful for diagnosis of meningococcal disease in children. J Clin Microbiol 42:2919–2925
Corless CE, Guiver M, Borrow R et al (2001) Simultaneous detection of Neisseria meningitidis, Haemophilus influenzae and Streptococcus pneumoniae in suspected cases of meningitis and septicaemia using real time PCR. J Clin Microbiol 39:1553–1558
Hackett SJ, Carrol ED, Guiver M et al (2002) Improved case confirmation in meningococcal disease with whole blood. TaqMan PCR. Arch Dis Child 86:449–452
Porritt RJ, Mercer J, Munro R (2000) Detection and serogroup determination of Neisseria meningitidis in CSF by polymerase chain reaction. Pathology 32:42–45
Public Health Laboratory Network (2006) Meningococcal infections laboratory case definition http://www.health.gov.au/internet/main/publishing.nsf/ Content/cda-phlncd-mening.htm. Accessed 6 October 2009
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Smith, H.V. (2010). Neisseria meningitidis. In: Schuller, M., Sloots, T., James, G., Halliday, C., Carter, I. (eds) PCR for Clinical Microbiology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9039-3_23
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DOI: https://doi.org/10.1007/978-90-481-9039-3_23
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