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Organization and Evolution of the Marsupial X Chromosome

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Marsupial Genetics and Genomics

Abstract

Marsupial genomics and genetics provide invaluable data for comparative analysis because these mammals are distantly related cousins of humans and other eutherian mammals (∼148 million years), but they are more closely related to eutherians compared to monotremes (∼166 million years) and birds (∼310 million years). This divergence time places them uniquely on the phylogenetic tree whereby comparative gene mapping and genome sequences of marsupials enable us to trace the evolution of the therian X chromosome. It is shown by comparative gene mapping that the marsupial X chromosome is homologous to the long arm and pericentric region of the short arm of the human X chromosome (X conserved region). However, it is homologous to autosomes in the platypus and the chicken, suggesting that a novel XY system evolved in therian mammals after they diverged from monotremes 166 million years ago but before marsupials diverged from eutherians 148 million years ago. Apart from the X conserved region, eutherian mammals have an autosomal addition on the X chromosome (X added region) since their divergence from marsupials. Although the marsupial X chromosome is similar in composition to that of the eutherian X chromosome, it has accumulated numerous rearrangements, has become GC rich and has acquired a higher synonymous substitution rate since divergence of marsupial and eutherian mammals. Similarly, the marsupial X chromosome undergoes X inactivation like eutherian mammals, but the mechanisms, which regulates X inactivation, is very different from that observed in eutherian mammal, and may be the ancestral state. The XIST gene responsible for X inactivation in eutherian mammals is absent from the marsupial lineage suggesting that the evolution of XIST in early eutherians set up selection for accumulation of LINE sequences that aided the spread of X inactivation. Unlike the LINE accumulation on the eutherian X chromosome, the marsupial X has accumulated and expanded a microRNA family that could be involved in the marsupial X inactivation. This chapter provides a comprehensive review of the organization and evolution of the marsupial X chromosome and the implications this may have for X inactivation.

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References

  • Alsop A, Miethke P, Rofe R, et al. (2005) Characterizing the chromosomes of the Australian model marsupial Macropus eugenii (tammar wallaby). Chromosome Res 13:627–636.

    Article  PubMed  CAS  Google Scholar 

  • Band MR, Larson JH, Rebeiz M, et al. (2000) An ordered comparative map of the cattle and human genomes. Genome Res 10:1359–1368.

    Article  PubMed  CAS  Google Scholar 

  • Bernardi G (2000) Isochores and the evolutionary genomics of vertebrates. Gene 241:3–17.

    Article  PubMed  CAS  Google Scholar 

  • Bininda-Emonds ORP, Cardillo M, Jones KE, et al. (2007) The delayed rise of present-day mammals. Nature 446:507–512.

    Article  PubMed  CAS  Google Scholar 

  • Bulazel K, Metcalfe C, Ferreri GC, Yu J, Eldridge MD, O’Neill RJ (2006) Cytogenetic and molecular evaluation of centromere-associated DNA sequences from a marsupial (Macropodidae: Macropus rufogriseus) X chromosome. Genetics 172:1129–1137.

    Article  PubMed  CAS  Google Scholar 

  • Burgoyne PS (1982) Genetic homology and crossing over in the X and Y chromosomes of mammals. Hum Genet 61:85.

    Article  PubMed  CAS  Google Scholar 

  • Carvalho BD, Oliveira LFB, Nunes AP, Mattevi MS (2002) Karyotypes of nineteen marsupial species from Brazil. J Mammal 83:58–70.

    Article  Google Scholar 

  • Charlesworth B (1978) Model for evolution of Y chromosomes and dosage compensation. Proc Natl Acad Sci USA 75:5618–5622.

    Article  PubMed  CAS  Google Scholar 

  • Charlesworth B, Coyne JA, Barton NH (1987) The relative rates of evolution of sex-chromosomes and autosomes. Am Nat 130:113–146.

    Article  Google Scholar 

  • Chojnowski JL, Franklin J, Katsu Y, et al. (2007) Patterns of vertebrate isochore evolution revealed by comparison of expressed mammalian, avian, and crocodilian genes. J Mol Evol 65:259–266.

    Article  PubMed  CAS  Google Scholar 

  • Costantini M, Clay O, Auletta F, Bernardi G (2006) An isochore map of human chromosomes. Genome Res 16:536–541.

    Article  PubMed  CAS  Google Scholar 

  • Costantini M, Cammarano R, Bernardi G (2009) The evolution of isochore patterns in vertebrate genomes. BMC Genomics 10:538.

    Article  PubMed  Google Scholar 

  • Craig JM, Earnshaw WC, Vagnarelli P (1999) Mammalian centromeres: DNA sequence, protein composition, and role in cell cycle progression. Exp Cell Res 246:249–262.

    Article  PubMed  CAS  Google Scholar 

  • Deakin JE, Koina E, Waters PD, et al. (2008) Physical map of two tammar wallaby chromosomes: a strategy for mapping in non-model mammals. Chromosome Res 16:1159–1175.

    Article  PubMed  CAS  Google Scholar 

  • Delbridge ML, Graves JA (2007) Origin and evolution of spermatogenesis genes on the human sex chromosomes. Soc Reprod Fertil Suppl 65:1–17.

    PubMed  CAS  Google Scholar 

  • Delbridge ML, Harry JL, Toder R, et al. (1997) A human candidate spermatogenesis gene, RBM1, is conserved and amplified on the marsupial Y chromosome. Nat Genet 15:131–136.

    Article  PubMed  CAS  Google Scholar 

  • Delbridge ML, Patel HR, Waters PD, McMillan DA, Marshall Graves JA (2009) Does the human X contain a third evolutionary block? Origin of genes on human Xp11 and Xq28. Genome Res 19:1350–1360.

    Article  PubMed  CAS  Google Scholar 

  • Devor EJ, Samollow PB (2008) In vitro and in silico annotation of conserved and nonconserved microRNAs in the genome of the marsupial Monodelphis domestica. J Hered 99:66–72.

    Article  PubMed  CAS  Google Scholar 

  • Devor EJ, Peek AS, Lanier W, Samollow PB (2009) Marsupial-specific microRNAs evolved from marsupial-specific transposable elements. Gene 448:187–191.

    Article  PubMed  CAS  Google Scholar 

  • Dhaliwal MK, Pathak S, Shirley LR, Flanagan JP (1988) Ag-nor Staining in the Bennett Wallaby, Macropus rufogriseus – Evidence for Dosage Compensation. Cytobios 56:29–38.

    PubMed  CAS  Google Scholar 

  • Duret L, Chureau C, Samain S, Weissenbach J, Avner P (2006) The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science 312:1653–1655.

    Article  PubMed  CAS  Google Scholar 

  • Emerson JJ, Kaessmann H, Betran E, Long M (2004) Extensive gene traffic on the mammalian X chromosome. Science 303:537–540.

    Article  PubMed  CAS  Google Scholar 

  • Felsenstein J (1974) The evolutionary advantage of recombination. Genetics 78:737–756.

    PubMed  CAS  Google Scholar 

  • Foster JW, Brennan FE, Hampikian GK, et al. (1992) Evolution of sex determination and the Y chromosome: SRY-related sequences in marsupials. Nature 359:531–533.

    Article  PubMed  CAS  Google Scholar 

  • Glas R, Graves JAM, Toder R, Ferguson-Smith M, O’Brien PC (1999a). Cross-species chromosome painting between human and marsupial directly demonstrates the ancient region of the mammalian X. Mamm Genome 10:1115–1116.

    Article  PubMed  CAS  Google Scholar 

  • Glas R, Leo A, Delbridge M, et al. (1999b). Chromosome painting in marsupials: genome conservation in the Kangaroo family. Chromosome Res 7:167–176.

    Article  PubMed  CAS  Google Scholar 

  • Goodstadt L, Heger A, Webber C, Ponting CP (2007) An analysis of the gene complement of a marsupial, Monodelphis domestica: evolution of lineage-specific genes and giant chromosomes. Genome Res 17:969–981.

    Article  PubMed  CAS  Google Scholar 

  • Graves JAM (1967) DNA synthesis in chromosomes of cultured leucocytes from two marsupial species. Exp Cell Res 46:37–57.

    Article  PubMed  CAS  Google Scholar 

  • Graves JAM (1995) The origin and function of the mammalian Y chromosome and Y-borne genes – an evolving understanding. Bioessays 17:311–320.

    Article  PubMed  CAS  Google Scholar 

  • Graves JAM (2006) Sex chromosome specialization and degeneration in mammals. Cell 124:901.

    Article  PubMed  Google Scholar 

  • Graves JAM (2008) Weird animal genomes and the evolution of vertebrate sex and sex chromosomes. Annu Rev Genet 42:565–586.

    Article  Google Scholar 

  • Graves JAM, Wakefield MJ, Toder R (1998) The origin and evolution of the pseudoautosomal regions of human sex chromosomes. Hum Mol Genet 7:1991–1996.

    Article  PubMed  CAS  Google Scholar 

  • Hayman DL (1990) Marsupial cytogenetics. Aust J Zool 37:331–349.

    Article  Google Scholar 

  • Hayman DL, Martin PG (1965) Sex chromosome mosaicism in the marsupial genera Isoodon and Perameles. Genetics 52:1201–1206.

    PubMed  CAS  Google Scholar 

  • Hayman D, Sharp P (1981) Verification of the structure of the complex sex chromosome system in Lagorchestes conspicillatus Gould (Marsupialia: Mammalia). Chromosoma 83:263–274.

    Article  PubMed  CAS  Google Scholar 

  • Hayman DL, Ashworth LK, Carrano AV (1982) The relative DNA contents of the eutherian and marsupial X-chromosomes. Cytogenet Cell Genet 34:265–270.

    Article  PubMed  CAS  Google Scholar 

  • Hellman A, Chess A (2007) Gene body-specific methylation on the active X chromosome. Science 315:1141–1143.

    Article  PubMed  CAS  Google Scholar 

  • Hore TA, Koina E, Wakefield MJ, Graves JAM (2007) The region homologous to the X-chromosome inactivation centre has been disrupted in marsupial and monotreme mammals. Chromosome Res 15:147–161.

    Article  PubMed  CAS  Google Scholar 

  • Hubbard TJ, Aken BL, Ayling S, et al. (2009) Ensembl 2009. Nucleic Acids Res 37:D690–D697.

    Article  PubMed  CAS  Google Scholar 

  • Huynh KD, Lee JT (2001) Imprinted X inactivation in eutherians: a model of gametic execution and zygotic relaxation. Curr Opin Cell Biol 13:690–697.

    Article  PubMed  CAS  Google Scholar 

  • Jacobs D (2004) The evolution of a neo-XY1Y2 sex chromosome system by autosome–sex chromosome fusion in Dundocoris nodulicarinus Jacobs (Heteroptera: Aradidae: Carventinae). Chromosome Res 12:175–191.

    Article  PubMed  CAS  Google Scholar 

  • Johnston PG, Davey RJ, Seebeck JH (1984) Chromosome homologies in Potorous-Tridactylus and Potorous-Longipes (Marsupialia, Macropodidae) based on G-Banding patterns. Aust J Zool 32:319–324.

    Article  Google Scholar 

  • Kohn M, Kehrer-Sawatzki H, Vogel W, Graves JAM, Hameister H (2004) Wide genome comparisons reveal the origins of the human X chromosome. Trends Genet 20:598.

    Article  PubMed  CAS  Google Scholar 

  • Koina E, Chaumeil J, Greaves IK, Tremethick DJ, Graves JAM (2009) Specific patterns of histone marks accompany X chromosome inactivation in a marsupial. Chromosome Res 17:115–126.

    Article  PubMed  CAS  Google Scholar 

  • Mank JE, Axelsson E, Ellegren H (2007) Fast-X on the Z: rapid evolution of sex-linked genes in birds. Genome Res 17:618–624.

    Article  PubMed  CAS  Google Scholar 

  • Mccarrey JR, Berg WM, Paragioudakis SJ, et al. (1992) Differential transcription of Pgk genes during spermatogenesis in the mouse. Dev Biol 154:160–168.

    Article  PubMed  CAS  Google Scholar 

  • Merry DE, Pathak S, VandeBerg JL (1983) Differential NOR activities in somatic and germ cells of Monodelphis domestica (Marsupialia, Mammalia). Cytogenetic Genome Res 35:244–251.

    Article  CAS  Google Scholar 

  • Mikkelsen TS, Wakefield MJ, Aken B, et al. (2007) Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature 447:167–177.

    Article  PubMed  CAS  Google Scholar 

  • Muller HJ (1918) Genetic variability, twin hybrids and constant hybrids, in a case of balanced lethal factors. Genetics 3:422–499.

    PubMed  CAS  Google Scholar 

  • Murphy WJ, Sun S, Chen Z-Q, Pecon-Slattery J, O’Brien SJ (1999) Extensive conservation of sex chromosome organization between cat and human revealed by parallel radiation hybrid mapping. Genome Res 9:1223–1230.

    Article  PubMed  CAS  Google Scholar 

  • Murray JD, McKay GM (1979) Y Chromosome mosaicism in pouch young of the marsupial, greater glider (Marsupialia: Petauridae). Chromosoma 72:329–334.

    Article  Google Scholar 

  • Noronha RCR, Nagamachi CY, O’Brien PCM, Ferguson-Smith MA, Pieczarka JC (2009) Neo-XY body: an analysis of XY1Y 2 meiotic behavior in Carollia (Chiroptera, Phyllostomidae) by chromosome painting. Cytogenetic Genome Res 124:37–43.

    Article  CAS  Google Scholar 

  • Ohno S (1967) Sex Chromosome and Sex-Linked Genes. Springer-Verlag, Berlin.

    Book  Google Scholar 

  • Ohno S, Jainchill J, Stenius C (1963) The Creeping Vole (Microtus Oregoni) as a gonosomic mosaic. I. the Oy/Xy constitution of the male. Cytogenetics 14:232–239.

    Article  PubMed  CAS  Google Scholar 

  • Page J, Berrios S, Rufas JS, et al. (2003) The pairing of X and Y chromosomes during meiotic prophase in the marsupial species Thylamys elegans is maintained by a dense plate developed from their axial elements. J Cell Sci 116:551–560.

    Article  PubMed  CAS  Google Scholar 

  • Pask A, Renfree MB, Graves JAM (2000) The human sex-reversing ATRX gene has a homologue on the marsupial Y chromosome, ATRY: implications for the evolution of mammalian sex determination. Proc Natl Acad Sci USA 97:13198–13202.

    Article  PubMed  CAS  Google Scholar 

  • Potrzebowski L, Vinckenbosch N, Marques AC, Chalmel F, Jegou B, Kaessmann H (2008) Chromosomal gene movements reflect the recent origin and biology of therian sex chromosomes. PLoS Biol 6:e80.

    Article  PubMed  Google Scholar 

  • Rappold GA (1993) The pseudoautosomal regions of the human sex chromosomes. Hum Genet 92:315–324.

    Article  PubMed  CAS  Google Scholar 

  • Rens W, O’Brien PCM, Fairclough H, Harman L, Graves JAM, Ferguson-Smith MA (2003) Reversal and convergence in marsupial chromosome evolution. Cytogenet Genome Res 102:282–290.

    Article  PubMed  CAS  Google Scholar 

  • Rice WR (1987a). Genetic hitchhiking and the evolution of reduced activity of the Y sex chromosome. Genetics 116:161–167.

    PubMed  CAS  Google Scholar 

  • Rice WR (1987b). The accumulation of sexually antagonistic genes as a selective agent promoting the evolution of reduced recombination between primitive sex chromosomes. Evolution 41:911–914.

    Article  Google Scholar 

  • Richler C, Soreq H, Wahrman J (1992) X-inactivation in mammalian testis is correlated with inactive X-specific transcription. Nat Genet 2:192–195.

    Article  PubMed  CAS  Google Scholar 

  • Robins AJ, Hayman DL, Wells JRE (1984) Ribosomal gene reiteration in a marsupial species with an X-linked nucleolar organizer. Aust J Biol Sci 37:211–215.

    PubMed  CAS  Google Scholar 

  • Rodriguez Delgado CL, Waters PD, Gilbert C, Robinson TJ, Graves JAM (2009) Physical mapping of the elephant X chromosome: conservation of gene order over 105 million years. Chromosome Res 17:917–926.

    Article  CAS  Google Scholar 

  • Rofe R, Hayman D (1985) G-banding evidence for a conserved complement in the Marsupialia. Cytogenet Cell Genet 39:40–50.

    Article  PubMed  CAS  Google Scholar 

  • Ross MT, Grafham DV, Coffey AJ, et al. (2005) The DNA sequence of the human X chromosome. Nature 434:325.

    Article  PubMed  CAS  Google Scholar 

  • Schmid M, Feichtinger W, Steinlein C, Haaf T, Visbal Garcia R, Fernandez Badillo A (2002) X chromosomes of American marsupials contain minimal amounts of euchromatin. Cytogenet Genome Res 99:315–322.

    Article  PubMed  CAS  Google Scholar 

  • Sharp P (1982) Sex chromosome pairing during male meiosis in marsupials. Chromosoma 86:27–47.

    Article  PubMed  CAS  Google Scholar 

  • Skaletsky H, Kuroda-Kawaguchi T, Minx PJ, et al. (2003) The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Nature 423:825–837.

    Article  PubMed  CAS  Google Scholar 

  • Spencer JA, Sinclair AH, Watson JM, Graves JAM (1991a). Genes on the short arm of the human X chromosome are not shared with the marsupial X. Genomics 11:339–345.

    Article  PubMed  CAS  Google Scholar 

  • Spencer JA, Watson JM, Graves JAM (1991b). The X chromosome of marsupials shares a highly conserved region with eutherians. Genomics 9:598–604.

    Article  PubMed  CAS  Google Scholar 

  • Svartman M, Vianna-Morgante AM (1998) Karyotype evolution of marsupials: from higher to lower diploid numbers. Cytogenet Cell Genet 82:263–266.

    Article  PubMed  CAS  Google Scholar 

  • Svartman M, Vianna-Morgante AM (2003) Conservation of chromosomal location of nucleolus organizer in American marsupials (Didelphidae). Genetica 118:11–16.

    Article  PubMed  CAS  Google Scholar 

  • Swinburne JE, Boursnell M, Hill G, et al. (2006) Single linkage group per chromosome genetic linkage map for the horse, based on two three-generation, full-sibling, crossbred horse reference families. Genomics 87:1–29.

    Article  PubMed  CAS  Google Scholar 

  • Thornton K, Bachtrog D, Andolfatto P (2006) X chromosomes and autosomes evolve at similar rates in Drosophila: no evidence for faster-X protein evolution. Genome Res 16:498–504.

    Article  PubMed  CAS  Google Scholar 

  • Toder R, O’Neill R, Wienberg J, O’Brien P, Voullaire L, Graves JAM (1997a). Comparative chromosome painting between two marsupials: origins of an XX/XY1Y2 sex chromosome system. Mamm Genome 8:418–422.

    Article  PubMed  CAS  Google Scholar 

  • Toder R, Wienberg J, Voullaire L, O’Brien PCM, Maccarone P, Graves JAM (1997b). Shared DNA sequences between the X and Y chromosomes in the tammar wallaby – evidence for independent additions to eutherian and marsupial sex chromosomes. Chromosoma 106:94–98.

    Article  PubMed  CAS  Google Scholar 

  • Toder R, Wakefield MJ, Graves JAM (2000) The minimal mammalian Y chromosome – the marsupial Y as a model system. Cytogenet Cell Genet 91:285–292.

    Article  PubMed  CAS  Google Scholar 

  • Torgerson DG, Singh RS (2003) Sex-linked mammalian sperm proteins evolve faster than autosomal ones. Mol Biol Evol 20:1705–1709.

    Article  PubMed  CAS  Google Scholar 

  • Turner JM, Mahadevaiah SK, Elliott DJ, et al. (2002) Meiotic sex chromosome inactivation in male mice with targeted disruptions of Xist. J Cell Sci 115:4097–4105.

    Article  PubMed  CAS  Google Scholar 

  • Vandeberg JL, Cooper DW, Sharman GB, Poole WE (1980) Somatic expression and autosomal inheritance of phosphoglycerate kinase-B in kangaroos. Genetics 95:413–424.

    PubMed  CAS  Google Scholar 

  • VandeBerg JL, Johnston PG, Cooper DW, Robinson ES (1983) X-chromosome inactivation and evolution in marsupials and other mammals. Isozymes Curr Top Biol Med Res 9:201–218.

    PubMed  CAS  Google Scholar 

  • Veyrunes F, Waters PD, Miethke P, et al. (2008) Bird-like sex chromosomes of platypus imply recent origin of mammal sex chromosomes. Genome Res 18:965–973.

    Article  PubMed  CAS  Google Scholar 

  • Vilella AJ, Severin J, Ureta-Vidal A, Heng L, Durbin R, Birney E (2009) EnsemblCompara GeneTrees: complete, duplication-aware phylogenetic trees in vertebrates. Genome Res 19:327–335.

    Article  PubMed  CAS  Google Scholar 

  • Warren WC, Hillier LW, Graves JAM, et al. (2008) Genome analysis of the platypus reveals unique signatures of evolution. Nature 453:175–183.

    Article  PubMed  CAS  Google Scholar 

  • Waters PD, Duffy B, Frost CJ, Delbridge ML, Graves JAM (2001) The human Y chromosome derives largely from a single autosomal region added to the sex chromosomes 80–130 million years ago. Cytogenet Cell Genet 92:74–79.

    Article  PubMed  CAS  Google Scholar 

  • Waters PD, Delbridge ML, Deakin JE, et al. (2005) Autosomal location of genes from the conserved mammalian X in the platypus (Ornithorhynchus anatinus): implications for mammalian sex chromosome evolution. Chromosome Res 13:401–410.

    Article  PubMed  CAS  Google Scholar 

  • Wilcox SA, Watson JM, Spencer JA, Graves JAM (1996) Comparative mapping identifies the fusion point of an ancient mammalian X-autosomal rearrangement. Genomics 35:66–70.

    Article  PubMed  CAS  Google Scholar 

  • Wutz A, Gribnau J (2007) X inactivation Xplained. Curr Opin Genet Dev 17:387–393.

    Article  PubMed  CAS  Google Scholar 

  • Young GJ, Graves JAM, Barbieri I, Woolley PA, Cooper DW, Westerman M (1982) The chromosomes of dasyurids (Marsupialia). In: Archer M (ed) Carnivorous Marsupials. Royal Zoological Society of New South Wales, Sydney.

    Google Scholar 

  • Yunis E, Ramirez E, Cayon J, Hernandez J (1972) The chromosomes of the Didelphids Caluromys Lanatus Illiger and Chironectes minimus Zimmerman (Marsupialia: Didelphidae). Aust J Zool 20:265–269.

    Article  Google Scholar 

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Authors and Affiliations

  1. ARC Centre for Kangaroo Genomics, Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, ACT, 0200, Australia

    Hardip R. Patel

  2. ARC Centre of Excellence for Kangaroo Genomics, Evolution, Ecology and Genetics, Research School of Biology, The Australian National University, Canberra, ACT, 0200, Australia

    Margaret L. Delbridge & Jennifer A. M. Graves

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  1. Hardip R. Patel
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  2. Margaret L. Delbridge
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Correspondence to Hardip R. Patel .

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Editors and Affiliations

  1. , Ecology, Evolution&Genetics, The Austral, ARC Centre for Excellence for Kangaroo G, Research School of Biology, building 46, Canberra ACT, 0200, Australia

    Janine E. Deakin

  2. , Ecology, Evolution&Genetics, The Austral, ARC Centre for Excellence for Kangaroo G, Research School of Biology, building 46, Canberra ACT, 0200, Australia

    Paul D. Waters

  3. , Ecology, Evolution and Genetics, ARC Centre of Excellence for Kangaroo Ge, Buidling 46, Canberra ACT, 0200, Australia

    Jennifer A. Marshall Graves

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Patel, H.R., Delbridge, M.L., Graves, J.A.M. (2010). Organization and Evolution of the Marsupial X Chromosome. In: Deakin, J., Waters, P., Marshall Graves, J. (eds) Marsupial Genetics and Genomics. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-9023-2_8

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