Fredrickson’s Classification of the Hyperlipoproteinaemias

Abstract

Serum lipids can be raised in association with several diseases, such as hypothyroidism and nephrotic syndrome (secondary hyperlipidaemia). Hypercholesterolaemia or hypertriglyceridaemia may also be primary, probably genetic. Fredrickson (1967) classified and described hyperlipidaemias, based on which classes of lipoprotein were elevated, so hyperlipoprotinaemias. Paper electrophoresis of lipoprotein was added to measurement of serum cholesterol and triglycerides. He described five types of hyperlipoprotinaemias, Types I to V. They require different management. Subsequently (1970) type II (hypercholesterolaemia) was subdivided into IIA or IIB – the latter accompanied by raised triglycerides. In 1972 familial combined hyperlipidaemia was defined. Years 1967–1973.