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Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles pp 115–129Cite as

Biomimetic Approaches to Design of Tissue Engineering Bioreactors

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Abstract

Tissue engineering is an attractive strategy to address the increasing clinical need for tissue replacement. Engineered tissues can also serve as high-fidelity models for studies of development, disease and therapeutic modalities. Cultivation of three-dimensional tissue equivalents is necessarily based on the use of bioreactors, which are designed to provide controlled steady state cultivation conditions as well as required biochemical and physical regulatory signals. In this chapter, we review the design and operation of tissue engineering bioreactors, with the focus on biomimetic approaches to provide in vivo-like environments for rapid and orderly tissue development by cells cultured on a scaffold. Specifically, we focus on bioreactors for tissue engineering of two distinctly different tissues – articular cartilage and myocardium.

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Acknowledgements

The authors would like to acknowledge funding of their research was funded by the Ministry of Science of the Republic of Serbia, grant 142075, Swiss National Science Foundation, grant IB73B0-111016/1 (BO), NIH grants P41 EB002520-01, R01 DE016525 and R01 HL076485-01 (GV), and ARTEC and NSERC Discovery Grant (MR).

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Authors and Affiliations

  1. Department of Chemical Engineering, Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11120, Belgrade, Serbia

    Bojana Obradovic

  2. Institute of Biomaterials and Biomedical Engineering, University of Toronto, 164 College St, Toronto, Ontario, M5S3G9, Canada

    Milica Radisic

  3. Department of Biomedical Engineering, Columbia University, 363G Engineering Terrace, Mail Code 8904, 1210 Amsterdam Avenue, New York, NY, 10027, USA

    Gordana Vunjak-Novakovic

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  1. Bojana Obradovic
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  2. Milica Radisic
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  3. Gordana Vunjak-Novakovic
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Correspondence to Bojana Obradovic .

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Editors and Affiliations

  1. Inst. Makromolekulare Chemie, Zentrum für Biologische Signalstudien, Universität Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany

    Venkatram Prasad Shastri

  2. Avançats (ICREA), Instituciò Catalana de Recerca i Estudis, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907, Spain

    George Altankov

  3. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Obradovic, B., Radisic, M., Vunjak-Novakovic, G. (2010). Biomimetic Approaches to Design of Tissue Engineering Bioreactors. In: Shastri, V., Altankov, G., Lendlein, A. (eds) Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8790-4_7

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