Biomimetic Approaches to Design of Tissue Engineering Bioreactors

  • Bojana ObradovicEmail author
  • Milica Radisic
  • Gordana Vunjak-Novakovic
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)


Tissue engineering is an attractive strategy to address the increasing clinical need for tissue replacement. Engineered tissues can also serve as high-fidelity models for studies of development, disease and therapeutic modalities. Cultivation of three-dimensional tissue equivalents is necessarily based on the use of bioreactors, which are designed to provide controlled steady state cultivation conditions as well as required biochemical and physical regulatory signals. In this chapter, we review the design and operation of tissue engineering bioreactors, with the focus on biomimetic approaches to provide in vivo-like environments for rapid and orderly tissue development by cells cultured on a scaffold. Specifically, we focus on bioreactors for tissue engineering of two distinctly different tissues – articular cartilage and myocardium.


Tissue engineering Cartilage Myocardium Bioreactor Oxygen transport Mechanical stimulation 



The authors would like to acknowledge funding of their research was funded by the Ministry of Science of the Republic of Serbia, grant 142075, Swiss National Science Foundation, grant IB73B0-111016/1 (BO), NIH grants P41 EB002520-01, R01 DE016525 and R01 HL076485-01 (GV), and ARTEC and NSERC Discovery Grant (MR).


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Bojana Obradovic
    • 1
    Email author
  • Milica Radisic
    • 2
  • Gordana Vunjak-Novakovic
    • 3
  1. 1.Department of Chemical Engineering, Faculty of Technology and MetallurgyUniversity of BelgradeBelgradeSerbia
  2. 2.Institute of Biomaterials and Biomedical EngineeringUniversity of TorontoTorontoCanada
  3. 3.Department of Biomedical EngineeringColumbia UniversityNew YorkUSA

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