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Bioreactor Systems in Regenerative Medicine

  • Ivan MartinEmail author
  • Stefania A. Riboldi
  • David Wendt
Conference paper
  • 968 Downloads
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)

Abstract

In this chapter, the functions and potential applicability of bioreactors from a technical, scientific and clinical perspective will be reviewed in the context of tissue engineering and regenerative medicine. In particular, examples will be given to illustrate the role of bioreactors in (a) establishing and maintaining 3D cell cultures, (b) standardizing physicochemical culture parameters, (c) physically conditioning engineered grafts, (d) predicting mechanical functionality of constructs to be implanted, (e) automating conventional tissue culture processes, (f) streamlining tissue manufacturing strategies. The critical role of bioreactors to make tissue engineered products clinically accessible, safe and commercially competitive will finally be discussed.

Keywords

Tissue engineering Cell-based therapy Graft manufacturing Physical conditioning Perfusion flow 

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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  • Ivan Martin
    • 1
    Email author
  • Stefania A. Riboldi
    • 1
  • David Wendt
    • 1
  1. 1.Institute for Surgical Research and Hospital Management, Departments of Surgery and of BiomedicineUniversity Hospital BaselBaselSwitzerland

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