Dermal Precursors and the Origins of the Wound Fibroblast

  • Jeffrey M. DavidsonEmail author
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)


Tissue repair demands the efficient restoration of connective tissue integrity and architecture. The brunt of the task falls on the fibroblast, a cell type strongly committed to the production of extracellular matrix. Recent investigation has refined the historical concept that the bone marrow and circulating precursors can make a significant, transient contribution to wound healing during the formation of granulation tissue. In parallel, there is mounting evidence that a subset of dermal mesenchymal cells have pluripotent properties that could contribute to the restoration and even regeneration of wound sites. The interrelationships between mesenchymal stem cells, circulating fibrocytes, and dermal progenitors are still an evolving area of investigation. Nevertheless, the manipulation of these cell types for wound healing and tissue engineering applications is a promising strategy.


Wound healing mesenchymal stem cell fibrocyte progenitor 



The author is grateful to Pampee P. Young, Susan R. Opalenik, and Mariagabriella Giro for their contributions to this work. Supported by the Department of Veterans Affairs and NIH grants AG06528 and AR041943.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Department of PathologyVanderbilt University School of MedicineNashvilleUSA
  2. 2.Research Service, VA Tennessee Valley Healthcare SystemNashvilleUSA

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