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Dermal Precursors and the Origins of the Wound Fibroblast

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Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles

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Abstract

Tissue repair demands the efficient restoration of connective tissue integrity and architecture. The brunt of the task falls on the fibroblast, a cell type strongly committed to the production of extracellular matrix. Recent investigation has refined the historical concept that the bone marrow and circulating precursors can make a significant, transient contribution to wound healing during the formation of granulation tissue. In parallel, there is mounting evidence that a subset of dermal mesenchymal cells have pluripotent properties that could contribute to the restoration and even regeneration of wound sites. The interrelationships between mesenchymal stem cells, circulating fibrocytes, and dermal progenitors are still an evolving area of investigation. Nevertheless, the manipulation of these cell types for wound healing and tissue engineering applications is a promising strategy.

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Acknowledgements

The author is grateful to Pampee P. Young, Susan R. Opalenik, and Mariagabriella Giro for their contributions to this work. Supported by the Department of Veterans Affairs and NIH grants AG06528 and AR041943.

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Authors and Affiliations

  1. Department of Pathology, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA

    Jeffrey M. Davidson

  2. Research Service, VA Tennessee Valley Healthcare System, 1310 24th Ave. South, Nashville, TN, 37212, USA

    Jeffrey M. Davidson

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  1. Jeffrey M. Davidson
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Correspondence to Jeffrey M. Davidson .

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Editors and Affiliations

  1. Inst. Makromolekulare Chemie, Zentrum für Biologische Signalstudien, Universität Freiburg, Stefan-Meier-Str. 31, Freiburg, 79104, Germany

    Venkatram Prasad Shastri

  2. Avançats (ICREA), Instituciò Catalana de Recerca i Estudis, Feixa Llarga s/n, L'Hospitalet de Llobregat, 08907, Spain

    George Altankov

  3. Geesthacht GmbH, Institut für Chemie, GKSS Forschungszentrum, Kantstraße 5, Teltow, 14513, Germany

    Andreas Lendlein

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Davidson, J.M. (2010). Dermal Precursors and the Origins of the Wound Fibroblast. In: Shastri, V., Altankov, G., Lendlein, A. (eds) Advances in Regenerative Medicine: Role of Nanotechnology, and Engineering Principles. NATO Science for Peace and Security Series A: Chemistry and Biology. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8790-4_4

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