Role of Spatial Distribution of Matricellular Cues in Controlling Cell Functions

  • Daniela Guarnieri
  • Paolo A. NettiEmail author
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)


The extracellular matrix (ECM) represents the quintessential material for tissue engineering (TE) applications, because it provides a structural support and regulates tissue development. Therefore, the main challenge in TE is to recreate ECM analogues that recapitulate the structural and molecular microenvironment to promote and guide tissue growth. Apart from composition, the distribution and presentation of molecular cues within the matrix are pivotal in controlling morphogenetic process. However, the role of matricellular signal presentation in terms of spatial and temporal orchestration is still poorly understood. This article overviews the development of systems able to control the spatial and temporal exposure of matricellular cues to the aim of guide cell response for tissue engineering applications.


Bioactive scaffold Signals presentation Cell guidance 


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© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Department of Materials and Production EngineeringUniversity of Naples “Federico II”NaplesItaly
  2. 2.Interdisciplinary Research Centre on Biomaterials (CRIB)University of Naples “Federico II”NaplesItaly

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