Cell Adhesions and Signaling: A Tool for Biocompatibility Assessment

  • Roumen PankovEmail author
  • Albena Momchilova
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)


Interactions between cells and extracellular environment are mediated through specific cell adhesion sites. These structures are responsible for transmitting environmental signals, which affect essentially all aspects of a cell’s life, including proliferation, differentiation and death. The morphology, organization and type of signaling transmitted through these adhesions depend on the chemical identity, geometry and the physical properties of the substrate. Here we outline the cell adhesions organized by fibroblasts on natural two- and within three-dimensional substrates, the signaling associated with these structures and discuss the possible use of this knowledge in assessment of surface biocompatibility of new materials, prepared for regenerative medicine.


Cell adhesions Focal contacts Fibrillar adhesions Three-dimensional matrix adhesions Integrins Extracellular matrix Cell signaling Biocompatibility Nanomaterials 



This work was supported in part through grants BУ-Б-1/05 and 1404/04 by the Bulgarian National Fund for Scientific Research.


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Copyright information

© Springer Science+Business Media B.V. 2010

Authors and Affiliations

  1. 1.Sofia University “St. Kliment Ohridski”SofiaBulgaria
  2. 2.Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial ResearchNational Institutes of HealthBethesdaUSA
  3. 3.Department of Cytology, Histology and Embryology, Faculty of BiologySofia UniversitySofiaBulgaria
  4. 4.Institute of Biophysics, Bulgarian Academy of SciencesSofiaBulgaria

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