Cell Adhesions and Signaling: A Tool for Biocompatibility Assessment
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Interactions between cells and extracellular environment are mediated through specific cell adhesion sites. These structures are responsible for transmitting environmental signals, which affect essentially all aspects of a cell’s life, including proliferation, differentiation and death. The morphology, organization and type of signaling transmitted through these adhesions depend on the chemical identity, geometry and the physical properties of the substrate. Here we outline the cell adhesions organized by fibroblasts on natural two- and within three-dimensional substrates, the signaling associated with these structures and discuss the possible use of this knowledge in assessment of surface biocompatibility of new materials, prepared for regenerative medicine.
KeywordsCell adhesions Focal contacts Fibrillar adhesions Three-dimensional matrix adhesions Integrins Extracellular matrix Cell signaling Biocompatibility Nanomaterials
This work was supported in part through grants BУ-Б-1/05 and 1404/04 by the Bulgarian National Fund for Scientific Research.
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