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Magnetic Resonance Imaging of Brain Tumors Using Iron Oxide Nanoparticles

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Methods of Cancer Diagnosis, Therapy, and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 8))

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Abstract

Iron oxide nanoparticles ­provide an alternative to gadolinium based contrast agents for use in magnetic resonance imaging of brain tumors. These nanoparticles have different biologic and imaging properties that provide complementary information about inflammation and subtle defects in the blood-brain barrier that are not seen with gadolinium as well as repeated serial imaging without the readministration of contrast agents. These particles can also be used with dynamic magnetic resonance imaging to measure perfusion properties of brain tumors without the confounding effects of blood brain barrier permeability on the measurements. Cellular labeling using iron oxide nanoparticles may allow for imaging of cellular trafficking in the brain.

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Authors and Affiliations

  1. Department of Neurosurgery, Oregon Health and Science University, 3181 SW, Sam Jackson Park Road, CR137, Portland, OR, 97239, USA

    Matthew A. Hunt & Edward A. Neuwelt

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  1. Matthew A. Hunt
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  2. Edward A. Neuwelt
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Correspondence to Matthew A. Hunt .

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  1. Dept. Biological Sciences, Kean University, Union, 07083, New Jersey, USA

    M. A. Hayat

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Hunt, M.A., Neuwelt, E.A. (2011). Magnetic Resonance Imaging of Brain Tumors Using Iron Oxide Nanoparticles. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8665-5_23

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  • DOI: https://doi.org/10.1007/978-90-481-8665-5_23

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