Abstract
Primary brain tumors exhibit an increased uptake of amino acids. Nuclear medicine utilizes this property of glioma for cancer imaging using radioactive amino acids. Single photon emission tomography (SPECT) using p-[123I]iodo-L-phenylalanine (IPA) is a valid method for brain tumor imaging. This chapter discusses the experience with IPA-SPECT in patients with suspected glioma or suspected progression/ recurrence of glioma. The imaging procedure, the coregistration process with nuclear magnetic resonance imaging (MRI), and potential pitfalls of image interpretation are described in detail. The clinical relevance of the results obtained in clinical studies is also discussed. The implications of quantitative analyses of the kinetics of IPA in brain tumors are reported in the light of the potential therapeutic application of radioiodinated IPA (131I-IPA).
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Hellwig, D. (2011). Brain Tumor Imaging Using p-[123I]Iodo-L-Phenylalanine and SPECT. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8665-5_18
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