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Hemorrhagic Brain Neoplasm – 99mTc-Methoxyisobutyl Isonitrile-Single Photon Emission Computed Tomography

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Methods of Cancer Diagnosis, Therapy, and Prognosis

Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 8))

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Abstract

Methoxyisobutylisonitrile (MIBI) is a technetium labeled compound introduced as an alternative to 201Tl for myocardial perfusion imaging. Because MIBI brain uptake is related not only to BBB ­disruption, as contrast enhancement on CT and MR scans, but also to the tumoral metabolic activity, 99mTc-MIBISPECT assists tumor grading evaluation, biopsy localization, and therapy monitoring, and permits differentiation of tumor recurrence from radiation necrosis. Moreover 99mTc-MIBISPECT is very helpful in distinguish the tumoral origin of cerebral hematoma. The reliability of this examination decreases over time and non-neoplastic ICH, showing no 99mTc-MIBI uptake within 2 days, can accumulate 99mTc-MIBI on more delayed imaging.

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Authors and Affiliations

  1. Clinica Neurochirurgica, Azienda Ospedaliera Universitaria Policlinico G. Martino, Via Consolare Valeria, 98100, Messina, Italy

    Filippo F. Angileri, Fabio Minutoli, Domenico La Torre & Sergio Baldari

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  1. Filippo F. Angileri
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  2. Fabio Minutoli
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  3. Domenico La Torre
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  4. Sergio Baldari
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Correspondence to Filippo F. Angileri .

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  1. Dept. Biological Sciences, Kean University, Union, 07083, New Jersey, USA

    M. A. Hayat

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Angileri, F.F., Minutoli, F., La Torre, D., Baldari, S. (2011). Hemorrhagic Brain Neoplasm – 99mTc-Methoxyisobutyl Isonitrile-Single Photon Emission Computed Tomography. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8665-5_17

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  • DOI: https://doi.org/10.1007/978-90-481-8665-5_17

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