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Methods of Cancer Diagnosis, Therapy, and Prognosis pp 121–129Cite as

Brain Tumors: Amide Proton Transfer Imaging

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Part of the book series: Methods of Cancer Diagnosis, Therapy and Prognosis ((HAYAT,volume 8))

Abstract

Amide proton transfer (APT) imaging is a new molecular MRI technique that detects endogenous mobile proteins and peptides in tissue. In this Chapter, the preclinical studies and pilot clinical data in brain tumor imaging are reviewed. APT imaging provides unique information regarding the presence and grade of brain tumors at the protein and peptide level. It has the potential to enhance the noninvasive detection and characterization of brain cancers before and after treatment.

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Acknowledgments.This work was supported in part by grants from NIH (RR015241 and EB002634) and the Dana Foundation.

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Authors and Affiliations

  1. Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, 217 Taylor Building, 720 Rutland Ave., Baltimore, MD, 21205, USA

    Jinyuan Zhou & Jaishri O. Blakeley

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  1. Jinyuan Zhou
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  2. Jaishri O. Blakeley
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Correspondence to Jinyuan Zhou .

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Editors and Affiliations

  1. Dept. Biological Sciences, Kean University, Union, 07083, New Jersey, USA

    M. A. Hayat

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Zhou, J., Blakeley, J.O. (2011). Brain Tumors: Amide Proton Transfer Imaging. In: Hayat, M. (eds) Methods of Cancer Diagnosis, Therapy, and Prognosis. Methods of Cancer Diagnosis, Therapy and Prognosis, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8665-5_11

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  • DOI: https://doi.org/10.1007/978-90-481-8665-5_11

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  • Online ISBN: 978-90-481-8665-5

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