Abstract
The diseases of the central nervous system may occur during pregnancy as well, although, pregnancy specific disorders of pregnant women are not known. However, certain neurologic diseases may be aggravated or influenced by pregnancy.
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References
Abramsky O. Pregnancy and multiple sclerosis. Ann Neurol 1994; 36(Suppl.): 38–41.
Adab N, Tudor SC, Vinten J et al. Common antiepileptic drugs in pregnancy in women with epilepsy. Cochrane Database Syst Rev 2004; (3): CD004848.
Aminoff MJ. Neurologic disorders. In: Creasy RK, Resnik R, Iams JD (eds.) Maternal-Fetal Medicine. 5th ed. Saunders, Philadelphia, 2004. pp. 1165–1191.
Berry RJ, Li Z, Erickson JD et al. Prevention of neural tube defects with folic acid in China. China-US Collaborative Project for Neural Tube Defect Prevention. N Engl J Med 1999; 341: 1485–1490.
Bjerkedahl T, Bahna SL. The occurrence and outcome of pregnancy in women with epilepsy. Acta Obstet Gynecol Scand 1973; 52: 245–248.
Bjekedahl T, CzeizelAE, Goujajrd J et al. Valproic acid and spina bifida. Lancet 1982; 2: 1096 only.
Botto LD, Olney RS, Erickson JD. Vitamin supplements and risk for congenital anomalies other than neural tube defects. Am J Med Genet C 2004; 125C: 12–21.
Dekker G, Sibai B. Primary, secondary and tertiary prevention of preeclampsia. Lancet 2001; 357: 209–215.
Diamond S. Migraine headache prevention and management. Marcel Dekker, New York, 1990.
Diav-Citrin O, Shechtman TW, Freeman RK, Yaffe SJ. Is carbamazepine teratogenic? A prospective controlled study of 210 pregnancies. Neurology 2001; 57: 321–324.
DiLiberti JH, Farndon PA, Dennis NR, Curry CJR. The fetal valproate syndrome. Am J Med Genet 1984; 19: 473–481.
Eldridge RR. Sumatriptan Pregnancy Register. Glaxo Wellcome Inc., Research Triangle Park, NC, 2000.
Esterez M, Gardner KL. Update on the genetics of migraine. Hum Genet 2004; 114: 225–235.
Facchinetty F, Allais G, D’Amico R et al. The relationship between headache and preeclampsia: a case-control study. Eur J Obstet Gynecol Reprod Biol 2005; 121: 143–148.
Fried S, Kozer E, Nulman I et al. Malformation rates in children of women with untreated epilepsy: a metanalysis. Dug Saf 2004; 27: 197–202.
German J, Lowal A, Ehlers KH. Trimethadione and human teratogenesis. Teratology 1970; 3: 349–362.
Giffin NJ, Kowacs F, Libri V. Effect of the adenosine A1 receptor agonist GR79236 on trigeminal nociception with blink reflex recordings in healthy human subjects. Cephalgia 2003; 23: 287–292.
Goadsby PJ. Migraine: diagnosis and management. Intern Med J 2003; 33: 436–442.
Hanson JW, Smith DW. The fetal hydantoin syndrome. J Pediatr 1975; 87: 305–312.
HCSIHS: Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders. 2nd ed. Cephalgia 2004; 24(Suppl.1): 1–151.
Hemels ME, Einarson A, Koren G et al. Antidepressant use during pregnancy and the rates of spontaneous abortions: a meta-analysis. Ann Pharmacother 2005; 39: 803–809.
Hiilesmaa VK, Teramo K, Granstrom M-L, Bardy AH. Fetal head growth retardation associated with maternal antiepileptic drugs. Lancet 1981; 2: 165–167.
Holmes LB, Harvey EA, Couil BA et al. The teratogenicity of anticonvulsants drugs. N Engl J Med 2001; 344: 1132–1138.
Janz D, Fuchs V. Are anti-epileptic drugs harmful when given during pregnancy? German Med Monog 1964; 9: 20–23.
Jones KL, Johnson KA. Chamber CC. Pregnancy outcome in women treated with phenobarbital monotherapy. Teratology 1992; 45: 452–453.
Kaaja E. Kaaja R, Hiilesmaa V. Major malformations on offspring of women with epilepsy. Neurology 2003; 60: 575–579.
Källen B. Maternal epilepsy, antiepileptic drugs and birth defects. Pathologica 1986; 78: 757–768.
Källen B, Lygner PE. Delivery outcome in women who used drugs for migraine during pregnancy with special reference to sumatriptan. Headache 2001; 41: 351–356.
Knight AH, Rhind EG. Epilepsy and pregnancy: a study of 153 pregnancies in 59 patients. Epilepsia 1975; 16: 99–110.
Koren G, Pastuszak A, Ito S. Drugs in pregnancy. N Engl J Med 1998; 338: 1128–1137.
Kurt AA. Association between migraine and cardiovasculat diseases. Expert Rev Neurother 2007; 7: 1097–1104
Laegread L, Olegard R, Wahlstrom J et al. Abnormalities in children exposed to benzodiazepines in utero. Lancet 1987; i: 108–109.
Laegread L, Hagberg G, Lundborg A. The effect of benzodiazepines in the fetus and the newborns. Neuropediatrics 1992; 23: 18–23.
Lance JW. The pharmacotherapy of migraine. Med J Austr 1986; 44: 85–88.
Lipton RB, Scher AI, Kolodner K. Migraine in the United States: epidemiology and patterns of health care use. Neurology 2002; 58: 885–894.
Lipton RB, Bigal ME, Goadsby PJ. Double-blind clinical trials of oral triptans vs. other classes of acute migraine medication – a review. Cephalgia 2004; 24: 321–332.
Lucas RN. Migraine in twins. J Psychosom Res 1977; 21: 147–156.
MacGregor EA, Brandes J, Eikermann A. Migraine prevalence and treatment: the Global Migraine and Zomitriptan Evaluation Survey. Headache 2003; 43: 19–26.
Marcoux S, Brisson J, Fabia J. Calcium intake from diary products and supplements and the risks of preeclampsia and gestational hypertension. Am J Epidemiol 1991; 133: 1266–1272.
Marcus DA. Migraine in women. Semin Pain Med 2004; 2: 115–122.
Marcus DA, Scharrf L, Mercer S, Turk DC. Nonpharmacological treatment for migraine: incremental utility of physical therapy with relaxation and thermal biofeedback. Cephalgia 1998; 18: 266–272.
Marcus DA, Scharff L, Turk DC. Longitudinal prospective study of Headache during pregnancy and postpartum. Headache 1999; 39: 625–632.
Markowitz S, Saito K, Moskowitz MA. Neurogenically mediated plasma extravasation in dura mater: effect of ergot alkaloids. A possible mechanism of action in vascular Headache. Cephalgia 1988; 8: 83–91.
Massey EW. Migraine during pregnancy. Survey Obstet Gynecol 1977; 32: 693–696.
Mathew Nt. Pathophysiology, epidemiology and impact of migraine. Clin Cornerstone 2001; 4: 1–17.
McGuirk CK, Westage MN, Holmes LB. Limb deficiencies in newborn infants. Pediatrics 2001; 108: e64.
Meadow SR. Anticonvulsant drugs and congenital abnormalities. Lancet 1968; 2: 1296.
Meadow KJ, Baker GA, Browning N et al. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med 2009; 360: 1597–1605.
Meadow K, Reynolds MW, Crean S et al. Pregnancy outcome in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts. Epilepsy 2008; 81: 1–13.
Medalie JH. Relationship between nausea and/or vomiting in early pregnancy and abortion. Lancet 1957; 273: 117–119.
Mitchell LE, Adrick NS, Melchionne J et al. Spina bifida. Lancet, 2004; 364: 1885–1895.
Monson RR, Rosenberg L, Harta SC et al. Diphenylhydantoin and selected congenital malformations. N Engl J Med 1973; 289: 1049–1052.
Montouris G. Gabapentin exposure in human pregnancy: results from Gabapentin Pregnancy Registry. Epilepsy Behav 2003; 4: 310–317.
MRC Vitamin Study Research Groups. Prevention of neural tube defect: results of Medical Research Council vitamin study. Lancet 1991; 338: 131–137.
Nakane Y, Okuma T, Takahashi R et al. Multi-institutional study on the teratogenicity and fetal toxicity of antiepileptic drugs. A report of a collaborative study group in Japan. Epilepsy 1980; 21: 663–680.
Narbone MC, Abbate M, Gangemi S. Acute drug treatment of migraine attack. Neurol Sci 2004; 25: S113–S118.
Olesen C, Steffensen FH, Sorensen HT. Pregnancy outcome following prescription for sumatriptan. Headache 2000; 40: 20–24.
Ophoff RA, Terwindt GM, Vergouwe MN. Familial hemiplegic migraine and episodic ataxia type-2 are caused by mutations in the CA2+-channel gene CACNL1A4. Cell 1996; 87: 543–552.
O’Quinn S, Ephross SA, Williams V et al. Pregnancy and perinatal outcomes in migreneurs using sumatriptan: a prospective study. Arch Gynecol Obstet 1999; 263: 7–12.
Poser S, Poser W. Multiple sclerosis and gestation. Neurology 1983; 33: 1422–1427.
Reik L Jr. Headaches in pregnancy. Semin Neurol 1988; 8: 187–192.
Roberts E, Guiband P. Maternal valproate acid and congenital neural tube defects. Lancet 1982; 2: 937 only.
Rosa FW. Spina bifida in infants of women treated with carbamazepine during pregnancy. N Engl J Med 1991; 324: 374–677.
Rosenberg L, Mitchell AA. Lack of correlation of oral clefts to diazepam use during pregnancy. N Engl J Med 1984; 310: 1122 only
Russel MB, Iselius L, Olesen J. Inheritance of migraine investigated by complex segregation analysis. Hum Genet 1995; 96: 726–730.
Russel MB, Hilden J, Sorensen SA, Olesen J. Familial occurrence of migraine without aura and migraine with aura. Neurology 1993; 43: 1369–1373.
Sadovnick AD, Eisen K, Hasimoto SA et al. Pregnancy and multiple sclerosis: a prospective study. Arch Neurol 1994; 54: 1120.
Safra MJ, Oakley GP. Association between cleft lip with or without cleft palate and prenatal exposure to diazepam. Lancet 1975; 2: 478–479.
Sances G, Granella F, Nappi RE. Course of migraine during pregnancy and postpartum: a prospective study. Cephalgia 2003; 23: 197–205.
Saxen I, Saxen L. Association between maternal intake of diazepam and oral clefts. Lancet 1975; 2: 498 only
Shapiro S, Hartz SC, Siskind V et al. Anticonvulsants and prenatal Epilepsy in the development of birth defects. Lancet 1976; 1: 272–275.
Shepard TH, Lemire RJ. Catalog of Teratogenic Agents. 11th ed. Johns Hopkins Univ Press, Baltimore, 2004.
Shunaiber S, Pastuszak A, Schick B. Pregnancy outcome following first trimester exposure to sumatriptan. Neurology 1998; 51: 581–583.
Silberstein SD, Lipton RB. Headache in Clinical Practice. Medical Media, Oxford, 1998. pp. 934–939.
Smithells RW, Sheppard S, Wild J, Schorach CJ. Prevention of neural tube defect recurrence in Yorkshire: final report. Lancet 1989; 2: 498–499.
Stewart WF, Linet MS, Celentano DD. Age- and sex-specific incidence rates of migraine with and without visual aura. Am J Epidemiol 1991; 34: 1111–1120.
Stewart WF, Lipton RB, Celentano DD, Reed ML. Prevalence of migraine Headaches in the United States. J Am Med Ass 1992; 267: 64–69.
Tfelt-Hansen P, Saxena PR. Ergot alkaloids in the acute treatment of migraine. In: Olesen J, Tfelt-Hansen P, Welch KMA (eds.) The Headaches. 2nd ed. Lippincott Williams and Wilkins, Philadelphia, 2000. pp. 399–409.
Tfelt-Hansen P, McEwen J. Nonsteroidal antiinflammatory drugs in the acute treatment of migraine. In: Olesen J, Tfelt-Hansen P, Welch KMA (eds.) The Headaches. 2nd ed. Lippincott Williams and Wilkins, Philadelphia, 2000. pp. 391–397.
Tompson T, Gram L, Siilanpaa M, Johannenssen SI. Epilepsy and Pregnancy. Wrightson Biomedical Publishing Ltd, Hampshire, 1997.
Villalon CM, Centurion D, Valdivia LF. Migraine: pathophysiology, pharmacology, treatment and future trends. Curr Vasc Pharmacol 2003; 1: 71–84.
Wainscott G, Sullivan FM, Volans GN, Wilkinson M. The outcome of pregnancy in women suffering from migraine. Postgrad Med J 1978; 54: 98–102.
Wall VR. Breastfeeding and migraine Headaches. J Hum Lact 1992; 8: 209–212.
Watson JD, Spellacy WN. Neonatal effects of maternal treatment with the anticonvulsant drug diphenylhydantoin. Obstet Gynecol 1971; 37: 881–885.
Weigel MM, Weigel R. Nausea and vomiting of early pregnancy and pregnancy outcomes. An epidemiological study. Br J Obstet Gynecol 1989; 96: 1304–1311.
Wyllie E (ed.) The Treatment of Epilepsy, Principles and Practice. 3rd ed. Lippincott Williams and Wilkins, Philadelphia, 2001.
Zackai EH, Melman WJ, Neiderer B, Hanson JW. The fetal trimethadione syndrome. J Pediatr 1975; 87: 280–284.
Own Publications
Kjaer D, Puhó HE, Christensen J, Vestergaard M, Czeizel AE, Sorensen HT, Olsen J. Use of phenytoin, phenobarbitals or diazepam during pregnancy and risk of congenital abnormalities: a case-time control study. Pharmacoepid Drug Safety 2007; 16: 181–188.
Czeizel AE, Dudás I. Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Engl J Med 1992; 327: 1832–1835.
Czeizel AE, Dobo M, Vargha P. Hungarian cohort-controlled trial of periconceptional multivitamin supplementation shows a reduction in certain congenital abnormalities. Birth Defects Res A 2004; 70: 853–861.
Czeizel AE. Prevention of congenital abnormalities by periconceptional multivitamin supplementation. Br J Med 1993; 306: 1645–1648.
Czeizel AE. Reduction of urinary tract and cardiovascular defects by periconceptional multivitamin supplementation. Am J Med Genet 1996; 62: 179–183.
Kjaer D, Puhó HE, Christensen J, Vestergaard M, Czeizel AE, Sorensen HT, Olsen J. Antiepileptic drugs, folic acid and congenital abnormalities – a Hungarian case-control study. Br J Obstet Gynecol 2008; 115: 98–103.
Bánhidy F, Ács N, Puho E, Czeizel AE. Pregnancy complications and delivery outcomes in pregnant women with migraine. Eur J Obstet Gynecol Reprod Biol 2007; 134: 403–409.
Bánhidy F, Ács N, Horváth-Puho E, Czeizel AE. Maternal severe migraine and risk of congenital limb deficiencies. Birth Defects Res A 2006; 76: 592–601.
Czeizel AE, Ács N, Bánidy F. Migraine in pregnant women (Review). Trends Reprod Biol 2008; 3: 1–8.
Czeizel AE, Evans JA, Kodaj I, Lenz W. Congenital Limb Deficiencies in Hungary. Genetic and Teratologic Epidemiologic Studies. Akadémiai Kiadó Budapest, 1994.
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Ács, N., Bánhidy, F., Czeizel, A.E. (2010). Diseases of the Nervous System. In: Ács, N., Bánhidy, F., Czeizel, A. (eds) Congenital Abnormalities and Preterm Birth Related to Maternal Illnesses During Pregnancy. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-8620-4_7
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